Patents by Inventor Hongming Chen
Hongming Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10864219Abstract: Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye.Type: GrantFiled: December 14, 2018Date of Patent: December 15, 2020Assignee: The Johns Hopkins UniversityInventors: Alexey Popov, Elizabeth M. Enlow, Hongming Chen, James Bourassa
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Patent number: 10861366Abstract: A display panel includes a plurality of scan lines and a scan driving circuit for driving the plurality of scan lines, where each of the plurality of scan lines extending in a first direction and sequentially aligned in a second direction, and the first direction intersects with the second direction; the scan driving circuit includes a first scan driving sub-circuit, a second scan driving sub-circuit, and a third scan driving sub-circuit, and the first scan driving sub-circuit is cascaded with the second scan driving sub-circuit; and the display panel includes a first area and a second area adjacent to each other in the second direction, the first scan driving sub-circuit drives scan lines in the first area in a progressive scan mode, and the second scan driving sub-circuit and the third scan driving sub-circuit respectively drive scan lines in the second area in an interlaced scan mode.Type: GrantFiled: August 10, 2018Date of Patent: December 8, 2020Assignee: WUHAN TIANMA MICRO-ELECTRONICS CO., LTD.Inventors: Kerong Wu, Yong Yuan, Hongming Chen
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Patent number: 10857096Abstract: Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye.Type: GrantFiled: June 8, 2020Date of Patent: December 8, 2020Assignee: The Johns Hopkins UniversityInventors: Alexey Popov, Elizabeth M. Enlow, Hongming Chen, James Bourassa
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Publication number: 20200368155Abstract: Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye.Type: ApplicationFiled: August 7, 2020Publication date: November 26, 2020Inventors: Alexey Popov, Elizabeth M. Enlow, Hongming Chen, James Bourassa
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Publication number: 20200368154Abstract: Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye.Type: ApplicationFiled: August 7, 2020Publication date: November 26, 2020Inventors: Alexey Popov, Elizabeth M. Enlow, Hongming Chen, James Bourassa
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Publication number: 20200297624Abstract: Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye.Type: ApplicationFiled: June 8, 2020Publication date: September 24, 2020Inventors: Alexey Popov, Elizabeth M. Enlow, Hongming Chen, James Bourassa
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Publication number: 20200289409Abstract: Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye.Type: ApplicationFiled: May 29, 2020Publication date: September 17, 2020Inventors: Alexey Popov, Elizabeth M. Enlow, Hongming Chen, James Bourassa
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Patent number: 10736854Abstract: Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.Type: GrantFiled: May 10, 2018Date of Patent: August 11, 2020Assignee: The Johns Hopkins UniversityInventors: Alexey Popov, Elizabeth M. Enlow, James Bourassa, Colin R. Gardner, Hongming Chen, Laura M. Ensign, Samuel K. Lai, Tao Yu, Justin Hanes, Ming Yang
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Patent number: 10704844Abstract: A heat exchanger including a first header and a second header; flat tubes, each having two ends connected to the first header and the second header respectively; a fin arranged between adjacent flat tubes; an input-output pipe welded to at least one header of the first header and the second header; and a water guide member disposed to the input-output pipe and/or the at least one header.Type: GrantFiled: July 5, 2016Date of Patent: July 7, 2020Assignee: SANHUA (HANGZHOU) MICRO CHANNEL HEAT EXCHANGER CO., LTD.Inventors: Huanghuang Xia, Hongming Chen
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Patent number: 10688045Abstract: Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye.Type: GrantFiled: November 9, 2017Date of Patent: June 23, 2020Assignee: The Johns Hopkins UniversityInventors: Alexey Popov, Elizabeth M. Enlow, Hongming Chen, James Bourassa
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Patent number: 10646437Abstract: Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye.Type: GrantFiled: May 11, 2018Date of Patent: May 12, 2020Assignee: The Johns Hopkins UniversityInventors: Alexey Popov, Elizabeth M. Enlow, Hongming Chen, James Bourassa
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Patent number: 10646436Abstract: Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye.Type: GrantFiled: May 11, 2018Date of Patent: May 12, 2020Assignee: The Johns Hopkins UniversityInventors: Alexey Popov, Elizabeth M. Enlow, Hongming Chen, James Bourassa
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Publication number: 20200140392Abstract: The present application relates to certain substituted imidazole compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating pain, musculoskeletal inflammation, neuroinflammatory disorders, airway inflammation, itch, dermatitis, colitis and related conditions.Type: ApplicationFiled: December 27, 2019Publication date: May 7, 2020Inventors: John Graham Cumming, Frank Xinhe Wu, Karl Henrik Edman, Hongming Chen, Dean Gordon Brown, Roland Werner Burli, Shawn Donald Johnstone, Giles Albert Brown, Benjamin Gerald Tehan, Barry John Teobald, Miles Stuart Congreve
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Patent number: 10550089Abstract: The present application relates to certain substituted imidazole and triazole compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating pain, musculoskeletal inflammation, neuroinflammatory disorders, airway inflammation, itch, dermatitis, colitis and related conditions. The compounds are of Formula (I) where X is N or CH, Z and Y are N or C (but both not N) and R1-R3 are as defined herein.Type: GrantFiled: May 11, 2017Date of Patent: February 4, 2020Assignee: Heptares Therapeutics LimitedInventors: John Graham Cumming, Frank Xinhe Wu, Karl Henrik Edman, Hongming Chen, Dean Gordon Brown, Roland Werner Burli, Shawn Donald Johnstone, Giles Albert Brown, Benjamin Gerald Tehan, Barry John Teobald, Miles Stuart Congreve
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Publication number: 20200010470Abstract: The present invention provides novel derivative of ?-lactam antibiotics, such as meropenem. The inventive compounds include compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. Also provided are particles (e.g., nanoparticles) and pharmaceutical compositions thereof that are mucus penetrating. The inventive particles and pharmaceutical compositions may be useful in delivering an inventive compound to the respiratory tract of a subject. The invention further provides methods of using and kits including the inventive compounds, particles thereof, and/or pharmaceutical compositions thereof for treating and/or preventing a pulmonary disease (e.g., a respiratory tract infection).Type: ApplicationFiled: July 11, 2019Publication date: January 9, 2020Inventors: Winston Zapanta Ong, Pawel Wojciech Nowak, Jinsoo Kim, Elizabeth M. Enlow, James Bourassa, Yen Cu, Alexey Popov, Hongming Chen
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Patent number: 10481748Abstract: A display panel and a display apparatus are provided. The display panel includes a display area and a non-display area surrounding the display area. The display panel includes at least one semiconductor pressure sensor disposed in the non-display area. Each semiconductor pressure sensor has a planar structure and is provided with a hollow-out zone. In various embodiments of the present disclosure, the pressure detection accuracy of the pressure sensors is improved and the user experience is enhanced.Type: GrantFiled: November 15, 2017Date of Patent: November 19, 2019Assignee: XIAMEN TIANMA MICRO-ELECTRONICS CO., LTD.Inventors: Zaiwen Zhu, Jieliang Li, Yong Yuan, Feng Lu, Qijun Yao, Hongming Chen
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Patent number: 10392388Abstract: The present invention provides novel derivative of ?-lactam antibiotics, such as meropenem. The inventive compounds include compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. Also provided are particles (e.g., nanoparticles) and pharmaceutical compositions thereof that are mucus penetrating. The inventive particles and pharmaceutical compositions may be useful in delivering an inventive compound to the respiratory tract of a subject. The invention further provides methods of using and kits including the inventive compounds, particles thereof, and/or pharmaceutical compositions thereof for treating and/or preventing a pulmonary disease (e.g., a respiratory tract infection).Type: GrantFiled: July 14, 2017Date of Patent: August 27, 2019Assignee: kala pharmaceuticals, Inc.Inventors: Winston Zapanta Ong, Pawel Wojciech Nowak, Jinsoo Kim, Elizabeth M. Enlow, James Bourassa, Yen Cu, Alexey Popov, Hongming Chen
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Publication number: 20190144394Abstract: The present application relates to certain substituted imidazole and triazole compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating pain, musculoskeletal inflammation, neuroinflammatory disorders, airway inflammation, itch, dermatitis, colitis and related conditions. The compounds are of Formula (I) where X is N or CH, Z and Y are N or C (but both not N) and R1-R3 are as defined herein.Type: ApplicationFiled: May 11, 2017Publication date: May 16, 2019Applicant: Heptares Therapeutics LimitedInventors: John Graham Cumming, Frank Xinhe Wu, Karl Henrik Edman, Hongming Chen, Dean Gordon Brown, Roland Werner Burli, Shawn Donald Johnstone, Giles Albert Brown, Benjamin Gerald Tehan, Barry John Teobald, Miles Stuart Congreve
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Publication number: 20190125758Abstract: Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye.Type: ApplicationFiled: December 14, 2018Publication date: May 2, 2019Inventors: Alexey Popov, Elizabeth M. Enlow, Hongming Chen, James Bourassa
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Publication number: 20190130807Abstract: A display panel includes a plurality of scan lines and a scan driving circuit for driving the plurality of scan lines, where each of the plurality of scan lines extending in a first direction and sequentially aligned in a second direction, and the first direction intersects with the second direction; the scan driving circuit includes a first scan driving sub-circuit, a second scan driving sub-circuit, and a third scan driving sub-circuit, and the first scan driving sub-circuit is cascaded with the second scan driving sub-circuit; and the display panel includes a first area and a second area adjacent to each other in the second direction, the first scan driving sub-circuit drives scan lines in the first area in a progressive scan mode, and the second scan driving sub-circuit and the third scan driving sub-circuit respectively drive scan lines in the second area in an interlaced scan mode.Type: ApplicationFiled: August 10, 2018Publication date: May 2, 2019Inventors: Kerong WU, Yong YUAN, Hongming CHEN