Abstract: Disclosed is a compound of formula (I) or a pharmaceutically acceptable salt, prodrug, tautomer or stereoisomer, and solvate thereof. The compound can be applied to treatment of cancers and inflammations of mammals. Further disclosed are a preparation method for the compound of formula (I) and a pharmaceutical composition containing the compound.

Abstract: A comprehensive geological-engineering classification evaluation method for low-permeability reservoirs, includes: constructing geological classification evaluation indexes of a reservoir: adopting gray correlation method to obtain main controlling factors of reservoir geology of the low-permeability reservoirs that affects fracturing effects; based on the main controlling factors of the reservoir geology, constructing the geological classification evaluation indexes of low-permeability reservoirs by principal component analysis; constructing engineering classification evaluation indexes of the reservoir: adopting gray correlation method to obtain main controlling factors of geomechanics of the low-permeability reservoirs that affects fracturing effects; based on the main controlling factors of geomechanics, constructing the engineering classification evaluation indexes of low-permeability reservoirs by an analytic hierarchy process; and according to classification limit values of the geological classificatio

Abstract: A rare earth-doped double-clad optical fiber includes a rare earth ion-doped fiber core, an inner cladding layer, and an outer cladding layer. A cross section of the inner cladding layer is a non-circular plane including at least two arcuate notches. According to the provided optical fiber, optical processing can be performed on a preform without changing a preform preparation process and a drawing process. The inner cladding is designed to have a non-circular planar structure having a cross section with at least two arcuate notches. While maintaining the same light absorption efficiency of pump light within the cladding layer, a preform polishing process is simplified, a risk of cracking the preform during polishing of multiple surfaces and a risk of contamination of the preform caused by impurities are reduced, wire drawing control precision is better, and comprehensive performance of the optical fiber is improved.

Abstract: A rare earth-doped double-clad optical fiber includes a rare earth ion-doped fiber core, an inner cladding layer, and an outer cladding layer. A cross section of the inner cladding layer is a non-circular plane including at least two arcuate notches. According to the provided optical fiber, optical processing can be performed on a preform without changing a preform preparation process and a drawing process. The inner cladding is designed to have a non-circular planar structure having a cross section with at least two arcuate notches. While maintaining the same light absorption efficiency of pump light within the cladding layer, a preform polishing process is simplified, a risk of cracking the preform during polishing of multiple surfaces and a risk of contamination of the preform caused by impurities are reduced, wire drawing control precision is better, and comprehensive performance of the optical fiber is improved.