Patents by Inventor Hongqin Zhuang

Hongqin Zhuang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of anaerobic tissue-targeted gene expression initiated by alcohol dehydrogenase promoter and the application thereof
    Patent number: 9708617
    Abstract: A proteomic screening method for anaerobic-specific and expression-effective promoter, and a method of specially delivering and selectively stably expressing target gene in anaerobic tissue by an alcohol dehydrogenase promoter and uses thereof. The latter comprises an anaerobically-induced alcohol dehydrogenase promoter which is used as target gene promoter, anaerobic target bacteria and low copy number plasmid. Therefore, the target gene can be specially and highly expressed under hypoxia condition in vivo or in vitro. The selective gene expression which is driven by the alcohol dehydrogenase promoter in anaerobic tissue can be used as gene therapy method to treat anaerobic tissue disease including tumor, or to prepare anti-tumor drug.
    Type: Grant
    Filed: May 13, 2011
    Date of Patent: July 18, 2017
    Assignee: NANJING UNIVERSITY
    Inventors: Zichun Hua, Jianxiang Chen, Dongping Wei, Hongqin Zhuang
  • METHOD OF ANAEROBIC TISSUE-TARGETED GENE EXPRESSION INITIATED BY ALCOHOL DEHYDROGENASE PROMOTER AND THE APPLICATION THEREOF
    Publication number: 20140093885
    Abstract: A proteomic screening method for anaerobic-specific and expression-effective promoter, and a method of specially delivering and selectively stably expressing target gene in anaerobic tissue by an alcohol dehydrogenase promoter and uses thereof. The latter comprises an anaerobically-induced alcohol dehydrogenase promoter which is used as target gene promoter, anaerobic target bacteria and low copy number plasmid. Therefore, the target gene can be specially and highly expressed under hypoxia condition in vivo or in vitro. The selective gene expression which is driven by the alcohol dehydrogenase promoter in anaerobic tissue can be used as gene therapy method to treat anaerobic tissue disease including tumor, or to prepare anti-tumor drug.
    Type: Application
    Filed: May 13, 2011
    Publication date: April 3, 2014
    Inventors: Zichun Hua, Jianxiang Chen, DONGPING WEI, Hongqin Zhuang