Patents by Inventor Hong-Qing Guo

Hong-Qing Guo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treating pain by targeting hyperpolarization-activated, cyclic nucleotide-gated channels
    Publication number: 20030022813
    Abstract: Markedly enhanced activity of pacemaker (hyperpolarization-activated, cation-nonselective, HCN) ion channels governs spontaneous firing in sensory cells of allodynic rats. An HCN ion channel specific blocker, ZD7288, dose-dependently and completely suppresses allodynia. Nerve injury increases the population of large DRG neurons expressing a high density of Ih and modulates HCN mRNA expression. New methods of treating pain by targeting HCN pacemaker channels are developed. In addition, new methods for identifying compositions useful for treating pain are disclosed.
    Type: Application
    Filed: May 30, 2002
    Publication date: January 30, 2003
    Inventors: Sandra Chaplan, Adrienne Dubin, Hong-Qing Guo, Doo Hyun Lee, Changlu Liu, Lin Luo, Sean Brown