Patents by Inventor Hongshan LAI

Hongshan LAI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of PRMT5 and methods of their use
    Patent number: 10723698
    Abstract: The disclosure relates to PRMT5 inhibitors, including optionally substituted N-alkyl-9H-carbazole analogs, derivatives thereof, and related compounds; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation and benign hematologic diseases using the compounds and compositions.
    Type: Grant
    Filed: July 19, 2018
    Date of Patent: July 28, 2020
    Assignee: The Ohio State University
    Inventors: Robert A. Baiocchi, Chenglong Li, Hongshan Lai, Said Sif
  • INHIBITORS OF PRMT5 AND METHODS OF THEIR USE
    Publication number: 20190270707
    Abstract: The disclosure relates to PRMT5 inhibitors, including optionally substituted N-alkyl-9H-carbazole analogs, derivatives thereof, and related compounds; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation and benign hematologic diseases using the compounds and compositions.
    Type: Application
    Filed: July 19, 2018
    Publication date: September 5, 2019
    Inventors: Robert A. Baiocchi, Chenglong Li, Hongshan Lai, Said Sif
  • Inhibitors of PRMT5 and methods of their use
    Patent number: 9856218
    Abstract: In one aspect, the invention relates to PRMT5 inhibitors, including optionally substituted N-alkyl-9H-carbazole analogs, derivatives thereof, and related compounds; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation and benign hematologic diseases using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: March 15, 2014
    Date of Patent: January 2, 2018
    Inventors: Robert A. Baiocchi, Chenglong Li, Hongshan Lai, Said Sif
  • INHIBITORS OF PRMT5 AND METHODS OF THEIR USE
    Publication number: 20160046578
    Abstract: In one aspect, the invention relates to PRMT5 inhibitors, including optionally substituted N-alkyl-9H-carbazole analogs, derivatives thereof, and related compounds; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation and benign hematologic diseases using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: March 15, 2014
    Publication date: February 18, 2016
    Inventors: Robert A. BAIOCCHI, Chenglong LI, Hongshan LAI, Said SIF