Patents by Inventor Hong Sheng Tan
Hong Sheng Tan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20160303069Abstract: The present invention provides compound extracted from Garcinia species and the use of said compound in preventing and treating cancer.Type: ApplicationFiled: April 15, 2016Publication date: October 20, 2016Inventors: Hong-xi XU, Yuan-zhi LAO, Zhi-jie DING, Hong ZHANG, Kai-xian CHEN, Hong-sheng TAN, Zhao-xiang BIAN, Cheng-yuan LIN, Shi-lin CHEN, Da-jian YANG, Ai-ping LU, Albert Sun Chi CHAN
-
Patent number: 9468623Abstract: The present invention provides compound extracted from Garcinia species and the use of said compound in preventing and treating cancer.Type: GrantFiled: April 15, 2016Date of Patent: October 18, 2016Assignee: Hong Kong Baptist UniversityInventors: Hong-xi Xu, Yuan-zhi Lao, Zhi-jie Ding, Hong Zhang, Kai-xian Chen, Hong-sheng Tan, Zhao-xiang Bian, Cheng-yuan Lin, Shi-lin Chen, Da-jian Yang, Ai-ping Lu, Albert Sun Chi Chan
-
Publication number: 20090264379Abstract: The invention provides an aqueous composition comprising a dissolved polyene fungicide and a solubilizer, wherein at least 100 ppm of polyene fungicide is present as dissolved polyene fungicide. The aqueous compositions of the invention may further comprise a chelating and/or antioxidation agent. The compositions of the invention provide dissolved polyene fungicides in a more stable form. The present invention further provides uses of the compositions of the inventions and methods of making such compositions.Type: ApplicationFiled: May 18, 2009Publication date: October 22, 2009Applicant: DSM IP ASSETS B.V.Inventors: Ben Rudolf de Haan, Jacobus Stark, Hong Sheng Tan
-
Publication number: 20060073249Abstract: The invention provides an aqueous composition comprising a dissolved polyene fungicide and a solubilizer, wherein at least 100 ppm of polyene fungicide is present as dissolved polyene fungicide. The aqueous compositions of the invention may further comprise a chelating and/or antioxidation agent. The compositions of the invention. provide dissolved polyene fungicides in a more stable form. The present invention further provides uses of the compositions of the inventions and methods of making such compositions.Type: ApplicationFiled: March 19, 2004Publication date: April 6, 2006Inventors: Ben Rudolf Haan, Jacobus Stark, Hong Sheng Tan
-
Patent number: 6369036Abstract: The present invention provides a method of preparing an improved antifungal composition containing an antifungal compound of the polyene type such as natamycin wherein the antifungal compound is incorporated into the composition in a form which shows an enhanced activity, e.g. in the form of a solution and/or being in a modified polymorphic form.Type: GrantFiled: April 30, 1998Date of Patent: April 9, 2002Assignee: DSM N.V.Inventors: Ferdinand Theodorus Van Rijn, Jacobus Stark, Hong Sheng Tan, Willem Johan Van Zoest, Nicolaas Cornelis Barendse
-
Patent number: 6117433Abstract: A dual chambered dispensing system allows for application of an aqueous composition containing a biologically effective compound which is adequately stabilized. The system separately contains the stabilized biologically effective compound composition in one chamber and an aqueous basic composition in the other. Both compositions are simultaneously delivered from the dispensing system, whereupon the compositions are mixed to result in a final composition suitable for direct application.Type: GrantFiled: April 28, 1998Date of Patent: September 12, 2000Assignee: DSM N.V.Inventors: Luppo Edens, Hong Sheng Tan, Johannes Wilhelmus Jacobus Lambers
-
Patent number: 5821233Abstract: Novel compositions that comprise solvates, salts, or other modified crystalline forms of polyene-type antifungal compounds are provided. Representative of such compositions are formulations that comprise the novel cystalline substances .delta.-natamycin and .gamma.-natamycin. Additionally, there are provided methods of preparing or storing such compositions, and also methods of use whereby an enhanced rate of release of antifungal compound, in a pharmaceutical or food products application is achieved.Type: GrantFiled: May 26, 1995Date of Patent: October 13, 1998Assignee: Gist-Brocades, N.V.Inventors: Ferdinand Theodorus Van Rijn, Jacobus Stark, Hong Sheng Tan, Willem Johan Van Zoest, Nicolaas Cornelis Barendse
-
Patent number: 5747078Abstract: Methods for long-term preservation of food products using a lactoperoxidase system. Long-term preservation is achieved by controlled generation of hydrogen peroxide as a substrate for the lactoperoxidase system. Controlled production of hydrogen peroxide is achieved by generating the hydrogen peroxide enzymatically form a system wherein the substrate for the enzyme generating the hydrogen peroxide is immobilized or is generated in situ from a precursor.Type: GrantFiled: January 13, 1995Date of Patent: May 5, 1998Assignee: Gist-brocades, N.V.Inventors: Sylvia Josefine De Jong, Ben Rudolf De Haan, Hong Sheng Tan
-
Patent number: 5552151Abstract: Concentrated suspensions of polyene fungicides such as natamycin are disclosed which exhibit good chemical, microbial and physical stability and which are thus particularly suitable as stock suspensions for the preparation of immersion liquids and coating emulsions for treatment of food, feed and agricultural products. Such suspensions have a pH in the range 3 to 4.8 and include a thickening agent.Type: GrantFiled: April 11, 1995Date of Patent: September 3, 1996Assignee: Gist-brocades B.V.Inventors: Bertus Noordam, Jacobus Stark, Ben R. De Haan, Hong Sheng Tan
-
Patent number: 4046761Abstract: Novel azetidine derivatives of the formula ##STR1## wherein R.sub.1 is an acylamido group, R.sub.2 is selected from the group consisting of ##STR2## wherein R.sub.4, R.sub.5 and R.sub.6 are individually selected from the group consisting of hydrogen, lower alkyl and lower alkenyl, n is 2 or 3 and -- in the case when formula IIB is a phenyl -- this group may carry 1 to 4 substituents selected from the group consisting of halogen, lower alkyl, lower alkenyl and phenyl, and R.sub.3 is lower alkyl optionally substituted with 1 or 2 phenyls which phenyl groups may be substituted with nitro and a process for their preparation and process for the preparation of cephalosporanic acid derivatives using the azetidines of formula I as intermediates.This is a division of Serial No. 547,948, filed Feb. 7, 1975 now Pat. No. 4,007,202.Type: GrantFiled: March 4, 1976Date of Patent: September 6, 1977Assignee: Gist-Brocades N.V.Inventors: Jan Verweij, Hong Sheng Tan
-
Patent number: 4035352Abstract: Novel 6-substituted amino-penicillanic acid anhydrides useful in the process for the preparation of 7-substituted amino-desacetoxycephalosporanic derivatives comprising converting a 6-substituted amino-penicillanic acid sulfoxide into an anhydride of a 6-substituted amino-penicillanic acid sulfoxide, heating the said acid anhydride intermediate at a temperature up to at most 160.degree. C in a dry inert organic solvent with an anhydrous acid which is capable of causing ring expansion of the penam ring to a .DELTA..sup.3 -cephem ring, in the presence of a silicon-containing compound capable of (a) removing water formed during the ring enlargement of the penam structure fast enough to prevent water hydrolysis of the acid anhydride moiety present and (b) forming neutral or basic products on hydrolysis, the aforesaid acid being strong enough not to be, or not to a substantial extent to be, silylated under the reaction conditions employed, and hydrolyzing the resulting compound in situ to form the .DELTA..sup.Type: GrantFiled: May 6, 1975Date of Patent: July 12, 1977Assignee: Gist-Brocades N.V.Inventors: Jan Verweij, Hong Sheng Tan, Hermanus Jacobus Kooreman
-
Patent number: 4007202Abstract: Novel azetidine derivatives of the formula ##STR1## wherein R.sub.1 is an acylamido group, R.sub.2 is selected from the group consisting of ##STR2## wherein R.sub.4, R.sub.5 and R.sub.6 are individually selected from the group consisting of hydrogen, lower alkyl and lower alkenyl, n is 2 or 3 and -- in the case when formula IIB is a phenyl - this group may carry one to four substituents selected from the group consisting of halogen, lower alkyl, lower alkenyl and phenyl, and R.sub.3 is lower alkyl optionally substituted with 1 or 2 phenyls which phenyl groups may be substituted with nitro and the dotted lines of formula IIB indicate the optional presence of double bonds and a process for their preparation and process for the preparation of cephalosporanic acid derivatives using the azetidines of formula I as intermediates.Type: GrantFiled: February 7, 1975Date of Patent: February 8, 1977Assignee: Gist-Brocades N.V.Inventors: Jan Verweij, Hong Sheng Tan
-
Patent number: 4003894Abstract: Process for the preparation of 7-substituted amino-desacetoxycephalosporanic derivatives comprising converting a 6-substituted amino-penicillanic acid sulfoxide into an anhydride of a 6-substituted amino-penicillanic acid sulfoxide, heating the said acid anhydride intermediate at a temperature up to at most 160.degree. C in a dry inert organic solvent with an anhydrous acid which is capable of causing ring expansion of the penam ring to a .DELTA..sup.3 -cephem ring, in the presence of a silicon-containing compound capable of (a) removing water formed during the ring enlargement of the penam structure fast enough to prevent water hydrolysis of the acid anhydride moiety present and (b) forming neutral or basic products on hydrolysis, the aforesaid acid being strong enough not to be, or not to a substantial extent to be, silylated under the reaction conditions employed, and hydrolyzing the resulting compound in situ to form the .DELTA..sup.Type: GrantFiled: May 5, 1975Date of Patent: January 18, 1977Assignee: Gist-Brocades N.V.Inventors: Jan Verweij, Hong Sheng Tan, Hermanus Jacobus Kooreman
-
Patent number: 3966738Abstract: New azetidine derivatives of the formula: ##EQU1## wherein R.sub.1 represents a penicillin- or cephalosporin-amido group, R.sub.2 represents one of the groups of the following formulae: ##EQU2## wherein R.sub.4, R.sub.5 and R.sub.6 are the same or different and each represents a hydrogen atom or a lower alkyl or alkenyl group, n represents 2 or 3 and - in case formula IIB represents a phenyl group - this group may carry one to four further substituents selected from the group consisting of halogen atoms and lower alkyl, lower alkenyl and phenyl groups, R.sub.3 represents an amino group of the formula ##EQU3## wherein R.sub.7 represents a hydrogen atom or a lower alkyl group and R.sub.8 represents a lower alkyl group, or R.sub.3 represents a N,N'-disubstituted hydrazino group wherein the substituents are lower alkyl groups, e.g. the N,N'-diisopropylhydrazino group, or R.sub.3 represents the group -OR.sub.9, wherein R.sub.Type: GrantFiled: February 8, 1974Date of Patent: June 29, 1976Assignee: Gist-Brocades N.V.Inventors: Jan Verwey, Hong Sheng Tan
-
Patent number: 3962277Abstract: A new azetidine derivative of the formula: ##EQU1## wherein R.sub.1 represents a penicillin- or cephalosporin-amido group, R.sub.2 represents one of the groups of the following formulae: ##EQU2## wherein R.sub.4, R.sub.5 and R.sub.6 are the same or different and each represents a hydrogen atom or a lower alkyl or alkenyl group, n represents 2 or 3 and - in case formula IIB represents a phenyl group - this group may carry one to four further substituents selected from the group consisting of halogen atoms and lower alkyl, lower alkenyl and phenyl groups,R.sub.3 represents an amino group of the formula ##EQU3## wherein R.sub.7 represents a hydrogen atom or a lower alkyl group and R.sub.8 represents a lower alkyl group, orR.sub.3 represents a N,N'-disubstituted hydrazino group wherein the substituents are lower alkyl groups, e.g. the N,N'-diisopropylhydrazino group, orR.sub.3 represents the group --OR.sub.9, wherein R.sub.Type: GrantFiled: October 6, 1975Date of Patent: June 8, 1976Assignee: Gist-Brocades N.V.Inventors: Jan Verwey, Hong Sheng Tan