Abstract: Disclosed is an apparatus configured to support growth of a 3D, hollow organoid. The apparatus contains a support structure and an enclosure, wherein a number of cells positioned between the support structure and the enclosure can grow on/around the support structure to form the organoid. The support structure additionally contains openings such that a fluid within the structure can flow into the organoid. The support structure may also extend between two fluid reservoirs configured to supply a fluid to the structure and organoid. The entire apparatus may be formed from an additive manufacturing process.

Abstract: Disclosed are methods and systems for implementing dynamic control of acoustic fields, which involves the use of machine learning through a Markov Decision Process. The machine learning algorithm monitors an attribute of a system and maintains the attribute within a range by altering a signal sent to an acoustic transducer. The acoustic transducer is configured to alter the attribute of the system. The attribute may be an attribute of the acoustic field produced by the acoustic transducer, or may be an attribute of another element of the system, such as a fluid, a rotor, or a cell mass.

Abstract: Embodiments of the present disclosure relate generally to methods used to perform diagnosis and drug screening because the method includes an algorithm that is able to obtain images of immune cells in 3D tissue cultures, analyze such images to create immune cell infiltration maps, automatically score and identify drugs or agents that can be potentially clinically beneficial.

Abstract: Disclosed is an apparatus, such as an acoustic for parallel profiling cell-matrix adhesion at single-cell level via the introduction of localized and uniform acoustic streaming into an open chamber microfluidic device. The adherent cells within the open chamber can be detached by the streaming-induced Stokes drag force, thereby allowing an accurate determination of the relevant forces and kinetics. The current device and method includes the digital regulation of acoustic streaming from a low level to high levels, and a large number of adherent cells can be ruptured from the substrate, and the particular adhesive forces and kinetics can be determined by the applied power. The acoustic device and the associated detachment technique can characterize the adhesion dynamics and kinetics of cells, such as mammalian cells and bacterial cells.

Abstract: A heating, ventilation and air conditioning (HVAC) system includes a compressor, a condenser operably connected to the compressor, and an evaporator operably connected to the compressor and to the condenser. A relocatable interface panel is in operable communication with one or more components of the HVAC system to issue commands to the HVAC system via operator inputs at the interface panel. An electrical lead connects the interface panel to the one or more components. A plurality of installation points are located at the HVAC system for installation of the interface panel thereto. The interface panel is selectably installed to an installation point of the plurality of installation points at an installation site of the HVAC system.

Abstract: A heating, ventilation and air conditioning (HVAC) system includes a compressor, a condenser operably connected to the compressor, and an evaporator operably connected to the compressor and to the condenser. A relocatable interface panel is in operable communication with one or more components of the HVAC system to issue commands to the HVAC system via operator inputs at the interface panel. An electrical lead connects the interface panel to the one or more components. A plurality of installation points are located at the HVAC system for installation of the interface panel thereto. The interface panel is selectably installed to an installation point of the plurality of installation points at an installation site of the HVAC system.