Abstract: Disclosed are compounds having the structure of Formula I, or a pharmaceutically acceptable salt of any thereof, wherein: “Z”, R1 and R2 are defined herein, which compounds are believed suitable for use in selectively antagonizing the A2a receptors, for example, those found in high density in the basal ganglia. Such compounds and pharmaceutical formulations are believed to be useful in treatment or management of neurodegenerative diseases, for example, Parkinson's disease, or movement disorders arising from use of certain medications used in the treatment or management of Parkinson's disease.

Abstract: A wheelchair includes a frame, a seat attached to the frame, a first forward wheel on a first side of the frame and a second forward wheel on a second side of the frame, a first rearward wheel on the first side of the frame and a second rearward wheel on the second side of the frame, a first drive wheel on the first side of the frame positioned intermediate between the first forward wheel and the first rearward wheel and a second drive wheel on the second side of the frame positioned intermediate between the second forward wheel and the second rearward wheel, and actuators to independently control the vertical position of the first forward wheel relative to the frame, the vertical position of the second forward wheel relative to the frame, the vertical position of the first rearward wheel relative to the frame, the vertical position of the second rearward wheel relative to the frame, the vertical position of the first drive wheel relative to the frame and the vertical position of the second drive wheel relati

Abstract: The present invention is directed to compounds of Formula I pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.

Abstract: A tubular solid state lighting device is disclosed having a light transmissive tube. A flexible carrier strip having a first portion attached to an inner wall section of the tube, and comprises an elongate major surface and a further elongate major surface opposite the elongate major surface. The elongate major surface carries a plurality of solid state lighting elements on the first portion and a plurality of electrically conductive contacts on adjacent terminal regions separated by a recess at one end. The flexible carrier strip is soldered to a rigid printed circuit board comprising a first major surface onto which a driver circuit for the solid state lighting elements is mounted facing the flexible carrier strip and a second major surface opposite the first major surface carrying a plurality of spatially separated soldering pads along an edge of the second major surface.

Abstract: Disclosed are compounds of Formula A and Formula A-1, or a salt thereof, and pharmaceutical formulations (pharmaceutical compositions) comprising those compounds, or a salt thereof; wherein “R1”, “RA-1”, “R2”, “R3”, and “Het” are defined herein above, which compounds are believed suitable for use in selectively antagonizing the A2a receptors, for example, those found in high density in the basal ganglia. Such compounds and pharmaceutical formulations are believed to be useful in treatment or management of neurodegenerative diseases, for example, Parkinson's disease, or movement disorders arising from use of certain medications used in the treatment or management of Parkinson's disease.

Abstract: The present invention relates to bicyclic aryl monobactam compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein A1, L, M, W, X, Y, Z, RX and Rz are as defined herein. The present invention also relates to compositions which comprise a bicyclic aryl monobactam compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. The invention further relates to methods for treating a bacterial infection comprising administering to the patient a therapeutically effective amount of a compound of the invention, either alone or in combination with a therapeutically effective amount of one or more beta-lactamase inhibitor compounds.

Abstract: The present invention relates to bicyclic aryl monobactam compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein A1, L, M, W, X, Y, Z, RX and Rz are as defined herein. The present invention also relates to compositions which comprise a bicyclic aryl monobactam compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. The invention further relates to methods for treating a bacterial infection comprising administering to the patient a therapeutically effective amount of a compound of the invention, either alone or in combination with a therapeutically effective amount of one or more beta-lactamase inhibitor compounds.

Abstract: A personal mobility device includes a frame, a plurality of wheels attached to the frame and one or more pneumatic motors. Each of the one or more pneumatic motors has a drive shaft in operative connection with at least one of the plurality of wheels. The personal mobility device further includes at least one tank (that is, a storage container) for storage of a pressurized gas in operative connection with the one or more pneumatic motors to supply pressurized gas to the one or more pneumatic motors and a control system in operative connection with the at least one tank and with the one or more pneumatic motors.

Abstract: The present invention relates to biaryl monobactam compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein X, Y, Z, A1, Q, M, W, RX and Rz are as defined herein. The present invention also relates to compositions which comprise a biaryl monobactam compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. The invention further relates to methods for treating a bacterial infection comprising administering to the patient a therapeutically effective amount of a compound of the invention, either alone or in combination with a therapeutically effective amount of a second beta-lactam antibiotic.

Abstract: Disclosed are compounds of Formula A and Formula A-1, or a salt thereof, and pharmaceutical formulations (pharmaceutical compositions) comprising those compounds, or a salt thereof; wherein “R1”, “RA-1”, “R2”, “R3”, and “Het” are defined herein above, which compounds are believed suitable for use in selectively antagonizing the A2a receptors, for example, those found in high density in the basal ganglia. Such compounds and pharmaceutical formulations are believed to be useful in treatment or management of neurodegenerative diseases, for example, Parkinson's disease, or movement disorders arising from use of certain medications used in the treatment or management of Parkinson's disease.

Abstract: Disclosed are compounds having the structure of Formula I, or a pharmaceutically acceptable salt of any thereof, wherein: “Z”, R1 and R2 are defined herein, which compounds are believed suitable for use in selectively antagonizing the A2a receptors, for example, those found in high density in the basal ganglia. Such compounds and pharmaceutical formulations are believed to be useful in treatment or management of neurodegenerative diseases, for example, Parkinson's disease, or movement disorders arising from use of certain medications used in the treatment or management of Parkinson's disease.

Abstract: A method and apparatus for treatment planning are described.

Abstract: The present invention relates to an end cap (104) for a tubular light source the tubular light source configured to be arranged in a lighting fixture comprising a socket, wherein the end cap (104) comprises a housing portion having a connection end, two connector pins (116) at least partly arranged on an outside of the housing portion at the connection end, wherein the connector pins (116) are configured to fit in the sockets of the lighting fixture, a first spring loaded switching element (110) configured to be alternately positioned in an actuated state and a non-actuated state, wherein the first spring loaded switching element (110) protrudes at the connection end of the housing portion in the vicinity of the connector pins (116) when positioned in its non-actuated state, and a second spring loaded switching element (112) configured to be positioned in an actuated state and a non-actuated state, wherein the switching elements (110, 112) are configured to be individually positioned in their respective actua

Abstract: A tubular solid state lighting device is disclosed having a light transmissive tube. A flexible carrier strip having a first portion attached to an inner wall section of the tube, and comprises an elongate major surface and a further elongate major surface opposite the elongate major surface. The elongate major surface carries a plurality of solid state lighting elements on the first portion and a plurality of electrically conductive contacts on adjacent terminal regions separated by a recess at one end. The flexible carrier strip is soldered to a rigid printed circuit board comprising a first major surface onto which a driver circuit for the solid state lighting elements is mounted facing the flexible carrier strip and a second major surface opposite the first major surface carrying a plurality of spatially separated soldering pads along an edge of the second major surface.

Abstract: Embodiments provide methods and systems for modeling the flow of fluid in variable physical and geological environments using dynamically determined Navier-Stokes equations (NSE), such as Darcy Flow and Poiseuille flow.

Abstract: The present invention relates to an end cap (104) for a tubular light source the tubular light source configured to be arranged in a lighting fixture comprising a socket, wherein the end cap (104) comprises a housing portion having a connection end, two connector pins (116) at least partly arranged on an outside of the housing portion at the connection end, wherein the connector pins (116) are configured to fit in the sockets of the lighting fixture, a first spring loaded switching element (110) configured to be alternately positioned in an actuated state and a non-actuated state, wherein the first spring loaded switching element (110) protrudes at the connection end of the housing portion in the vicinity of the connector pins (116) when positioned in its non-actuated state, and a second spring loaded switching element (112) configured to be positioned in an actuated state and a non-actuated state, wherein the switching elements (110, 112) are configured to be individually positioned in their respective actua

Abstract: A wheelchair system includes a wheelchair including at least one adjustable seating function, a sensor system in operative connection with the wheelchair which includes at least one sensor to measure or sense a position of the at least one adjustable seating function, a processor system in operative connection with the sensor system, a memory system in operative connection with the processor system, and a communication system in operative connection with the processor system. The communication system is, for example, adapted to wirelessly communicate with one or more remote systems (that is, a system remote from the wheelchair; for example a remote system or server, which may include a database). The wheelchair system further includes a user interface system in operative connection with the processor system and at least one application stored on the memory system and executable by the processor system.

Abstract: A method and apparatus for treatment planning are described. A treatment planning system provides a computer-simulated virtual environment including a virtual artifact that is a three-dimensional simulation of a patient anatomy, wherein the three-dimensional simulation is generated from one or more diagnostic images taken of the patient anatomy. The treatment planning system performs a treatment planning operation associated with the virtual artifact in response to a user interaction with the virtual environment.

Abstract: Angle adjustable backrest made of a lightweight, durable, adjustable, backrest for ultralight manual wheelchairs. Light-weight material can include composites for a rigid backrest for promotion of healthier and functional interface. Angle adjustment can be any desired range such as a range from ?5 degree to 55 degrees (i.e. 85 degrees to 145 degree with respect to horizontal with the seat). No tools are necessary for any of the angle adjustments. The backrest has a horizontal adjustment (fore-aft) that can be any desired range such as 1 inch. The height selection depends on the length of the wheelchair frame tubes. The present invention improves the ease and simplicity of adjusting the backrest by or for the user, as well as enhances the aesthetic appearance and adds features necessary for achieving commercial readiness. The present invention can be retro fit onto a wide range for ultralight wheelchairs.

Abstract: A method and apparatus for treatment planning are described.