Abstract: The present invention provides a model for high-throughput screening of endocrine disruptors and a method for screening the same. In the present invention, primary structural alerts, secondary structural alerts and tertiary structural alerts of compounds are extracted according to a nuclear receptor, and then the primary structural alerts, the secondary structural alerts and the tertiary structural alerts form a nuclear receptor high-throughput screening model; hierarchical structural alert matching is carried out on target compounds through the nuclear receptor high-throughput screening model, and ligand-receptor binding mode analysis and semi-quantitative prediction of binding activity and disrupting activity are performed.

Abstract: The present disclosure provides an antibody-drug conjugate intermediate containing SN38 and a preparation method thereof, comprising introducing a biologically active water-soluble group PEG into its linker and structurally modifying PEG. The preparation method is simple in steps and cost-saving, and does not introduce heavy metal ions in reactions with higher environmental friendliness. Moreover, the antibody-drug conjugate intermediate synthesized by the preparation method has higher stability and efficacy compared with antibody-drug conjugate intermediates with SN38 as toxin in the prior art.

Abstract: Disclosed is a method for high-throughput screening of non-target biomarkers based on metabolic disturbance caused by pollutants, belonging to the field of environmental exposure and health.

Abstract: Disclosed is a method for high-throughput screening of non-target biomarkers based on metabolic disturbance caused by pollutants, belonging to the field of environmental exposure and health.

Abstract: The present invention provides a model for high-throughput screening of endocrine disruptors and a method for screening the same. In the present invention, primary structural alerts, secondary structural alerts and tertiary structural alerts of compounds are extracted according to a nuclear receptor, and then the primary structural alerts, the secondary structural alerts and the tertiary structural alerts form a nuclear receptor high-throughput screening model; hierarchical structural alert matching is carried out on target compounds through the nuclear receptor high-throughput screening model, and ligand-receptor binding mode analysis and semi-quantitative prediction of binding activity and disrupting activity are performed.

Abstract: Implementations herein relates to effect-directed identification of targeted and non-targeted androgen disruptors. The implementations include primary separation, androgenic activity testing, high throughput separation and preparation of toxicants, active component scanning based on high performance liquid chromatography-time of flight mass spectrometry, targeted screening of suspicious androgenic substances, non-target identification of androgenic compounds combining mass spectrum, chromatography and toxicity characteristics and toxicity confirmation. The implementations perform separation using SPE and preparative separation in series to obtain high throughput separation fractions, utilize DMSO as a protective agent to optimize concentration of second fractions, utilize target databases to achieve target identification of key toxicants.

Abstract: The present patent relates to a method for qualitative identification and quantitative prediction of thyroid hormone disrupting chemicals base on the interaction between thyroid hormone receptor and co-regulators (coactivator and corepressor). The method identifies chemicals as passive antagonists, active antagonists and agonists by means of co-regulator involved molecular dynamics simulations, and predicts the relative disrupting potencies by use of binding free energy, therefore, may be used for screening of thyroid hormone disruptors among environmental pollutants. Upon more comprehensive consideration of the functioning mechanism of thyroid hormone receptor, the present invention is able to sufficiently identify thyroid hormone disruptors as agonists and antagonists, and gives more accurate prediction of the disrupting potency.

Abstract: Implementations herein relates to effect-directed identification of targeted and non-targeted androgen disruptors. The implementations include primary separation, androgenic activity testing, high throughput separation and preparation of toxicants, active component scanning based on high performance liquid chromatography-time of flight mass spectrometry, targeted screening of suspicious androgenic substances, non-target identification of androgenic compounds combining mass spectrum, chromatography and toxicity characteristics and toxicity confirmation. The implementations perform separation using SPE and preparative separation in series to obtain high throughput separation fractions, utilize DMSO as a protective agent to optimize concentration of second fractions, utilize target databases to achieve target identification of key toxicants.

Abstract: The present patent relates to a method for qualitative identification and quantitative prediction of thyroid hormone disrupting chemicals base on the interaction between thyroid hormone receptor and co-regulators (coactivator and corepressor).The method identifies chemicals as passive antagonists, active antagonists and agonists by means of co-regulator involved molecular dynamics simulations, and predicts the relative disrupting potencies by use of binding free energy, therefore, may be used for screening of thyroid hormone disruptors among environmental pollutants. Upon more comprehensive consideration of the functioning mechanism of thyroid hormone receptor, the present invention is able to sufficiently identify thyroid hormone disruptors as agonists and antagonists, and gives more accurate prediction of the disrupting potency.

Abstract: The present invention provides a controller used in a TRIAC dimmer compatible LED driver and method thereof. The controller comprises a dimming signal generator, a dimming signal processor and a switch control circuit. The dimming signal generator receives an AC chopped voltage from a TRIAC dimmer and generates a dimming signal with regulated duty cycle in accordance with the AC chopped voltage. The dimming signal processor is coupled to the dimming signal generator and generates a processed dimming signal in accordance with the dimming signal. The duty cycle of the processed dimming signal is a sum of a predetermined duty cycle and the duty cycle of the dimming signal. Based on the processed dimming signal and a feedback signal indicative of the current flowing through LED, the switch control circuit generates a control signal to control at least one switch in a switching converter.

Abstract: A fast startup switching converter having a first switch, a second switch, a third switch, a first capacitor, and a controller controlling the ON and OFF switching of the second and third switches. The first terminal of the first switch is coupled to the input terminal of the switching converter, the second terminal is coupled to the first terminal of the second switch. The first terminal of the third switch is coupled to the second terminal of the first switch and the first terminal of the second switch. The first capacitor is coupled to the second terminal of the third switch and the controller to provide a power supply voltage for the controller. The switching converter charges the first capacitor through the first and third switches in a first working state, and transfers energy to a load through the first and second switches in a second working state.

Abstract: A power supply system having a voltage source; a load; a filter circuit to filter the voltage provided by the voltage source and to output a filtered voltage; and a follower circuit configured to generate an output signal at an output of the follower circuit based on the filtered voltage, and further wherein the output of the follower circuit is coupled to the load.

Abstract: The present invention provides a controller used in a TRIAC dimmer compatible LED driver and method thereof. The controller comprises a dimming signal generator, a dimming signal processor and a switch control circuit. The dimming signal generator receives an AC chopped voltage from a TRIAC dimmer and generates a dimming signal with regulated duty cycle in accordance with the AC chopped voltage. The dimming signal processor is coupled to the dimming signal generator and generates a processed dimming signal in accordance with the dimming signal. The duty cycle of the processed dimming signal is a sum of a predetermined duty cycle and the duty cycle of the dimming signal. Based on the processed dimming signal and a feedback signal indicative of the current flowing through LED, the switch control circuit generates a control signal to control at least one switch in a switching converter.

Abstract: A fast startup switching converter comprises a first switch, a second switch, a third switch, a first capacitor, and a controller controlling the ON and OFF switching of the second and third switches. The first terminal of the first switch is coupled to the input terminal of the switching converter, the second terminal is coupled to the first terminal of the second switch. The first terminal of the third switch is coupled to the second terminal of the first switch and the first terminal of the second switch. The first capacitor is coupled to the second terminal of the third switch and the controller to provide a power supply voltage for the controller. The switching converter charges the first capacitor through the first and third switches in a first working state, and transfers energy to a load through the first and second switches in a second working state.