Patents by Inventor Hongxia Zeng
Hongxia Zeng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240034741Abstract: Methods are disclosed including methods for crystallizing a material such as a drug. An example method may include combining a nucleation initiator, a surfactant solution, and an amorphous form of a drug to form a drug precursor dispersion/suspension. The method may also include incubating the drug precursor dispersion/suspension to allow the drug to convert from the amorphous form to a crystalline form.Type: ApplicationFiled: October 6, 2023Publication date: February 1, 2024Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: HONGXIA ZENG, JONATHAN PASCAL CHAKY, YEN-LANE CHEN
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Patent number: 11814397Abstract: Methods are disclosed including methods for crystallizing a material such as a drug. An example method may include combining a nucleation initiator, a surfactant solution, and an amorphous form of a drug to form a drug precursor dispersion/suspension. The method may also include incubating the drug precursor dispersion/suspension to allow the drug to convert from the amorphous form to a crystalline form.Type: GrantFiled: March 12, 2021Date of Patent: November 14, 2023Assignee: Boston Scientific Scimed, Inc.Inventors: Hongxia Zeng, Jonathan Pascal Chaky, Yen-Lane Chen
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Publication number: 20220160997Abstract: A radiopaque anchor and delivery device system may comprise a pigtail catheter and a radiopaque anchor. The pigtail catheter may be a dual lumen catheter configured to deploy the radiopaque anchor and delivery a radiopaque fluid or contrast agent. The implantable radiopaque anchor may be slidably disposed within and deployable from a lumen of the elongate shaft.Type: ApplicationFiled: November 22, 2021Publication date: May 26, 2022Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Dongming Hou, Hongxia Zeng, Tim O'Connor, Bryan Allen Clark
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Publication number: 20220111114Abstract: In some aspects, the disclosure pertains to injectable particles that contain at least one pH-altering agent that is configured to be released from the injectable particles in vivo, upon embolization of an intratumoral artery of a tumor with the injectable particles. In certain instances, the pH altering agent may be a basic agent having a pH value of 7.5, a buffering agent having a pKa value of 7.6 or more, or both. Other aspects of the disclosure pertain to preloaded containers containing such injectable particles and methods of using such injectable particles.Type: ApplicationFiled: December 21, 2021Publication date: April 14, 2022Inventors: Hongxia Zeng, Bruce R. Forsyth, Hong Cao, Matthew R. DeWitt, Heidi Schwanz
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Patent number: 11241239Abstract: An occlusive implant includes an expandable framework that is configured to shift between a collapsed configuration and an expanded configuration. An occlusive member is disposed along at least a portion of the expandable framework. At least part of the occlusive implant is configured to repel fibrinogen. In some cases, the occlusive implant may be configured for placement within a left atrial appendage (LAA) of a patient's heart.Type: GrantFiled: May 15, 2019Date of Patent: February 8, 2022Assignee: Boston Scientific Scimed, Inc.Inventors: Hong Cao, Dongming Hou, Hongxia Zeng
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Patent number: 11235084Abstract: In some aspects, the disclosure pertains to injectable particles that contain at least one pH-altering agent that is configured to be released from the injectable particles in vivo, upon embolization of an intratumoral artery of a tumor with the injectable particles. In certain instances, the pH-altering agent may be a basic agent having a pH value of 7.5, a buffering agent having a pKa value of 7.6 or more, or both. Other aspects of the disclosure pertain to preloaded containers containing such injectable particles and methods of using such injectable particles.Type: GrantFiled: July 12, 2018Date of Patent: February 1, 2022Assignee: Varian Medical Systems, Inc.Inventors: Hongxia Zeng, Bruce R. Forsyth, Hong Cao, Matthew R. DeWitt, Heidi Schwanz
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Publication number: 20210300938Abstract: Methods are disclosed including methods for crystallizing a material such as a drug. An example method may include combining a nucleation initiator, a surfactant solution, and an amorphous form of a drug to form a drug precursor dispersion/suspension. The method may also include incubating the drug precursor dispersion/suspension to allow the drug to convert from the amorphous form to a crystalline form.Type: ApplicationFiled: March 12, 2021Publication date: September 30, 2021Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: HONGXIA ZENG, JONATHAN PASCAL CHAKY, YEN-LANE CHEN
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Publication number: 20200093745Abstract: Polymer microspheres for embolizing blood vessels and optionally delivering therapeutic agents are provided.Type: ApplicationFiled: October 9, 2019Publication date: March 26, 2020Inventors: Hongxia Zeng, Steven Kangas, Yen-Lane Chen
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Publication number: 20200038559Abstract: In one aspect, the present disclosure pertains to elutable coating compositions that comprise an excipient comprising a bio-degradable or bio-stable polymer selected from a poly(lactic-co-glycolic acid) (PLGA) or methyl cellulose (MCC), a binding agent; a therapeutic agent. In some embodiments, the elutable coating compositions further comprise a solvent, in which case such compositions may be, for example, applied to a substrate in the form of a layer and subsequently dried, thereby forming an elutable coating on the substrate.Type: ApplicationFiled: July 30, 2019Publication date: February 6, 2020Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: HONGXIA ZENG, JONATHAN PASCAL CHAKY, MING DANG, YEN-LANE CHEN
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Publication number: 20190350591Abstract: An occlusive implant includes an expandable framework that is configured to shift between a collapsed configuration and an expanded configuration. An occlusive member is disposed along at least a portion of the expandable framework. At least part of the occlusive implant is configured to repel fibrinogen. In some cases, the occlusive implant may be configured for placement within a left atrial appendage (LAA) of a patient's heart.Type: ApplicationFiled: May 15, 2019Publication date: November 21, 2019Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Hong Cao, Dongming Hou, Hongxia Zeng
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Patent number: 10471012Abstract: Polymer microspheres for embolizing blood vessels and optionally delivering therapeutic agents are provided. The microspheres include PLGA 50:50 and/or Ptx, and are generally formed by emulsion means.Type: GrantFiled: January 4, 2016Date of Patent: November 12, 2019Assignee: Boston Scientific Scimed, Inc.Inventors: Hongxia Zeng, Steven L. Kangas, Yen-Lane Chen
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Publication number: 20190015545Abstract: In some aspects, the disclosure pertains to injectable particles that contain at least one pH-altering agent that is configured to be released from the injectable particles in vivo, upon embolization of an intratumoral artery of a tumor with the injectable particles. In certain instances, the pH-altering agent may be a basic agent having a pH value of 7.5, a buffering agent having a pKa value of 7.6 or more, or both. Other aspects of the disclosure pertain to preloaded containers containing such injectable particles and methods of using such injectable particles.Type: ApplicationFiled: July 12, 2018Publication date: January 17, 2019Inventors: Hongxia Zeng, Bruce R. Forsyth, Hong Cao, Matthew R. DeWitt, Heidi Schwanz
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Publication number: 20180344248Abstract: Medical systems and methods for making and using medical systems are disclosed. An example may include a catheter, a sensor, and a pump configured to remove contrast from a vascular system. The catheter may have a lumen through which the pump may suction contrast. The sensor may be positioned distal of and upstream of a distal end of the aspiration lumen and the pump may initiate suction through the lumen in response to a value sensed by the sensor reaching and/or going beyond a threshold value. The catheter may include an expandable member configured to expand in response to a value sensed by the sensor reaching and/or going beyond a threshold value. The sensor may be supported by a distal extension of the catheter or an elongate member configured to extend through and/or along the catheter to position the sensor distal of the distal end of the aspiration lumen.Type: ApplicationFiled: June 1, 2018Publication date: December 6, 2018Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: HONGXIA ZENG, DONGMING HOU, HONG CAO, BIN MI
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Publication number: 20160262917Abstract: A medical device includes a tubular network of struts including a bioerodible polymer. The tubular network can include a plurality of bands and a plurality of connector struts. Each band can include a plurality of peaks between adjacent band struts. Each band can be connected to one or more adjacent bands by at least two connector struts at a plurality of connector intersections. The bioerodible polymer can include a plurality of polymer chains functionalized with a photo active group.Type: ApplicationFiled: March 10, 2016Publication date: September 15, 2016Inventors: JOHN J. CHEN, STEVEN L. KANGAS, YEN-LANE CHEN, HONGXIA ZENG, RAGHAV GOEL
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Publication number: 20160220490Abstract: Polymer microspheres for embolizing blood vessels and optionally delivering therapeutic agents are provided. The microspheres include PLGA 50:50 and/or Ptx, and are generally formed by emulsion means.Type: ApplicationFiled: January 4, 2016Publication date: August 4, 2016Applicant: Boston Scientific Scimed, Inc.Inventors: Hongxia Zeng, Steven L. Kangas, Yen-Lane Chen
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Publication number: 20150250772Abstract: A medical device having a polymer-free outer surface layer comprising a crystalline drug selected from the group consisting of everolimus, tacrolimus, sirolimus, zotarolimus, biolimus, and rapamycin. The device may be produced by a method comprising the steps of providing a medical device; applying a solution of the drug to said portion of the outer surface to form a coating of amorphous drug; and vapor annealing the drug with a solvent vapor to form crystalline drug; wherein a seed layer of a crystalline form of said drug having a maximum particle size of about 10 ?m or less is applied to at least said portion of the outer surface of the device before or after applying the drug solution, but before vapor annealing the amorphous coating.Type: ApplicationFiled: May 22, 2015Publication date: September 10, 2015Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Steven L. Kangas, James Q. Feng, Hongxia Zeng, Yen-Lane Chen
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Publication number: 20150238736Abstract: A catheter system includes a catheter having a first balloon and a second balloon. The first balloon is longitudinally offset from the second balloon along the length of the catheter. The first and second balloons both have expanded and unexpanded states. The second balloon has a drug coating. The catheter system has a first configuration, a second configuration, and a third configuration. In the first configuration, the first balloon is in the unexpanded state and the second balloon is in the unexpanded state. In the second configuration, the first balloon is in the expanded state and the second balloon is in the unexpanded state. In the third configuration, the first balloon is in the expanded state and the second balloon is in the expanded state.Type: ApplicationFiled: February 27, 2015Publication date: August 27, 2015Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Hongxia Zeng, Yen-Lane Chen, Steven L. Kangas
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Publication number: 20150182732Abstract: A catheter comprises a medical balloon having a drug coating. The drug coating comprises drug crystals on a surface of the balloon. The majority of the drug crystals on the surface of the balloon are oriented drug crystals which extend within 5° of a predetermined, non-zero common angle relative to the surface of the balloon from which the crystals extend.Type: ApplicationFiled: December 29, 2014Publication date: July 2, 2015Applicant: Boston Scientific Scimed, Inc.Inventors: Hongxia Zeng, Yen-Lane Chen, Steven L. Kangas
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Publication number: 20150018431Abstract: In one aspect, the present disclosure pertains to lubricous coating compositions that comprise (a) a higher molecular weight polyvinylpyrrolidone, (b) a lower molecular weight polyvinylpyrrolidone, and (c) a polyfunctional unsaturated crosslinking agent. In some embodiments, such lubricous coating compositions are present in crosslinked form on the surface of a medical article. In some embodiments, the lubricous coating compositions further comprise a solvent, in which case such compositions may be, for example, applied to a substrate in the form of a layer and subsequently crosslinked, thereby forming a lubricious coating on the substrate. In another aspect, the present disclosure is directed to methods for forming various medical articles.Type: ApplicationFiled: July 14, 2014Publication date: January 15, 2015Inventors: Hongxia Zeng, Jan Seppala, Yen-Lane Chen, Raghav Goel
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Publication number: 20070104778Abstract: The present invention is directed to controlled-release composition containing a solubilized material comprising an active agent and at least one oil-based surfactant capable of solubilizing the active agent, the solubilized material dispersed in a controlled-release particulate matrix.Type: ApplicationFiled: November 7, 2006Publication date: May 10, 2007Inventors: Hongxia Zeng, Antonio Moroni, Anand Baichwal, Philip Goliber, Sara Ketsela, Daniel McNamara