Abstract: The present invention provides methods, compositions, systems, and kits comprising nano-satellite complexes and/or serum albumin carrier complexes, which are used for modulating antigen-specific immune response (e.g., enhancing anti-tumor immunity). In certain embodiments, the nano-satellite complexes comprise: a) a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core; b) at least one satellite particle attached to, or absorbed to, the biocompatible coating; and c) an antigenic component conjugated to, or absorbed to, the at least one satellite particle component. In certain embodiments, the complexes further comprise: d) a type I interferon agonist agent. In some embodiments, the serum albumin complexes comprise: a) at least part of a serum albumin protein, b) an antigenic component conjugated to the carrier protein, and c) a type I interferon agonist agent.

Abstract: A rotation guidance apparatus belonging to the technical field of oil drilling equipment. An end part of a lower connector has a ball-socketed ball-joint rod, and a drill bit is connected to the ball-socketed ball-joint rod. Several circumferentially and evenly distributed piston holes are provided in a side wall of the lower connector, wherein a piston matches each piston hole and a piston rod connected to the piston is movably connected to the ball-socketed ball-joint rod. An eccentrically-placed valve core is connected to a controller provided in an upper connector, wherein a working face of the eccentrically-placed valve core is opposite to the piston holes and rotation of the eccentrically-placed valve core makes the pistons in the piston holes move to control the rotation guidance of the ball-socketed ball-joint rod.

Abstract: Disclosed is a rotation guidance apparatus belonging to the technical field of oil drilling equipment. An end part of a lower connector (3) has a ball-socketed ball-joint rod (12), and a drill bit (1) is connected to the ball-socketed ball-joint rod (12); several circumferentially and evenly distributed piston holes are provided in a side wall of the lower connector (3), a piston matches each piston hole, and a piston rod (11) connected to the piston is movably connected to the ball-socketed ball-joint rod (12); and a eccentrically-placed valve core (17) is connected to a controller provided in an upper connector (4), a working face of the eccentrically-placed valve core (17) is opposite to the piston holes, and rotation of the eccentrically-placed valve core (17) makes the pistons in the piston holes move to control the rotation guidance of the ball-socketed ball-joint rod (12).