Patents by Inventor Hongya PAN

Hongya PAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROTEINS AND USE THEREOF
    Publication number: 20250034239
    Abstract: The disclosure provides proteins specifically binding to Vascular Endothelial Growth Factor (VEGF), transferrin and/or properdin.
    Type: Application
    Filed: October 11, 2024
    Publication date: January 30, 2025
    Inventors: Zhaozhong HAN, Hongya PAN, Lingyu LI, Mengfan PENG, Jun LUO, Haiyang LI
  • VEGF-BINDING PROTEIN AND USE THEREOF
    Publication number: 20250011409
    Abstract: The present disclosure provides an isolated antigen-binding protein, having one or more properties selected from the group consisting of: 1) an ability of specifically binding to VEGFA (Vascular Endothelial Growth Factor A); 2) an ability of preventing VEGF from binding its corresponding receptor (s); and 3) an ability of inhibiting VEGF-driven biological functions. The present application also provides bi-paratopic antigen-binding proteins and polypeptides comprising the isolated antigen-binding protein and their use thereof.
    Type: Application
    Filed: November 24, 2021
    Publication date: January 9, 2025
    Applicant: LINNO PHARMACEUTICALS INC.
    Inventors: Zhaozhong HAN, Hongya PAN
  • Properdin binding protein and use thereof
    Patent number: 12162931
    Abstract: The present disclosure provides an isolated antigen binding protein. The isolated antigen binding protein can specifically bind to properdin. The present disclosure also provides an anti-properdin antibody and a preparation method and an application thereof.
    Type: Grant
    Filed: September 1, 2023
    Date of Patent: December 10, 2024
    Assignee: LINNO PHARMACEUTICALS INC.
    Inventors: Zhaozhong Han, Lingyu Li, Mengfan Peng, Haiyang Li, Jun Luo, Hongya Pan
  • Transferrin binding antibodies and use thereof
    Patent number: 12144866
    Abstract: The present disclosure provides a method to translocate a molecule across cellular membrane by using a transferrin-binding protein. The transferrin-binding protein is capable of specifically binding to transferrin and not disturbing the interaction between transferrin and transferrin receptor.
    Type: Grant
    Filed: June 1, 2023
    Date of Patent: November 19, 2024
    Assignee: LINNO PHARMACEUTICALS INC.
    Inventors: Zhaozhong Han, Hongya Pan, Mengfan Peng
  • Recombinant hARSA that crosses the blood brain barrier
    Patent number: 12084690
    Abstract: The present application pertains to a fusion protein, comprising a transferrin-binding protein, and an arylsulfatase A (ARSA) or functionally active fragment thereof, wherein the transferrin-binding protein comprises a peptide, an antibody or an antigen-binding fragment of the antibody capable of binding transferrin. The other aspect of the present application provides the preparing methods and the uses of the fusion protein.
    Type: Grant
    Filed: October 17, 2023
    Date of Patent: September 10, 2024
    Assignee: LINNO PHARMACEUTICALS INC.
    Inventors: Zhaozhong Han, Hongya Pan, Haiyang Li, Lingyu Li
  • TRANSFERRIN BINDING ANTIBODIES AND USE THEREOF
    Publication number: 20240226315
    Abstract: The present disclosure provides a method to translocate a molecule across cellular membrane by using a transferrin-binding protein. The transferrin-binding protein is capable of specifically binding to transferrin and not disturbing the interaction between transferrin and transferrin receptor.
    Type: Application
    Filed: June 1, 2023
    Publication date: July 11, 2024
    Applicant: LINNO PHARMACEUTICALS INC.
    Inventors: Zhaozhong HAN, Hongya PAN, Mengfan PENG
  • PROPERDIN BINDING PROTEIN AND USE THEREOF
    Publication number: 20240174739
    Abstract: The present disclosure provides an isolated antigen binding protein. The isolated antigen binding protein can specifically bind to properdin. The present disclosure also provides an anti-properdin antibody and a preparation method and an application thereof.
    Type: Application
    Filed: September 1, 2023
    Publication date: May 30, 2024
    Applicant: LINNO PHARMACEUTICALS INC.
    Inventors: Zhaozhong HAN, Lingyu LI, Mengfan PENG, Haiyang LI, Jun LUO, Hongya PAN
  • TRANSFERRIN BINDING ANTIBODIES AND USE THEREOF
    Publication number: 20240131177
    Abstract: The present disclosure provides a method to translocate a molecule across cellular membrane by using a transferrin-binding protein. The transferrin-binding protein is capable of specifically binding to transferrin and not disturbing the interaction between transferrin and transferrin receptor.
    Type: Application
    Filed: May 31, 2023
    Publication date: April 25, 2024
    Applicant: LINNO PHARMACEUTICALS INC.
    Inventors: Zhaozhong HAN, Hongya PAN, Mengfan PENG
  • A RECOMBINANT HARSA THAT CROSSES THE BLOOD BRAIN BARRIER
    Publication number: 20240101981
    Abstract: The present application pertains to a fusion protein, comprising a transferrin-binding protein, and an arylsulfatase A (ARSA) or functionally active fragment thereof, wherein the transferrin-binding protein comprises a peptide, an antibody or an antigen-binding fragment of the antibody capable of binding transferrin. The other aspect of the present application provides the preparing methods and the uses of the fusion protein.
    Type: Application
    Filed: October 17, 2023
    Publication date: March 28, 2024
    Inventors: Zhaozhong HAN, Hongya PAN, Haiyang LI, Lingyu LI