Abstract: Provided are an anti-CLDN6 antibody or an antigen-binding fragment thereof; a nucleic acid molecule encoding same; an immunoconjugate, a bispecific molecule, a chimeric antigen receptor and a pharmaceutical composition containing same; and the use thereof for preventing and/or treating tumors.

Abstract: A clip (100) for use in an endoscopic gastrointestinal procedure includes a first arm (110), a second arm (120), and an end effector (130). The first arm (110) includes a first proximal end (110b) and a first distal end (110a). The second arm (120) includes a second proximal end (120b) and a second distal end (120a). The end effector (130) is fixedly coupled to the second arm (120) and extends from the second arm (120) distally relative to the second distal end (120a). The first arm (110) and the second arm (120) are pivotable relative to each other between an open position and a closed position in which tissue is clampable between the first arm (110) and the second arm (120). The end effector (130) is configured to be inserted into the tissue by rotating the clip (100) about a first axis (130a).

Abstract: An anastomosis clamp (1) and a delivery system thereof, where the anastomosis clamp (1) includes inner lancets (102, 602), round corners (103, 603), and outer rings (101, 601) that are sequentially connected; the delivery system may be used in cooperation with the anastomosis clamp (1); and the delivery system includes a distal end (2), a middle flexible sheath (3), and a handle (4).

Abstract: A cold snare includes a spring tube, a drive wire, and a loop. The cable passes through the spring tube, and can perform reciprocating motion in a direction of a longitudinal axis of the spring tube. The loop is fixedly connected to a distal end of the drive wire. Therefore, when the drive wire performs reciprocating motion in the direction of the longitudinal axis of the spring tube, the loop synchronously performs reciprocating motion in the direction of the longitudinal axis of the spring tube along with the drive wire to achieve the purpose of controlling the loop to enter and exit the spring tube by the drive wire. By using a spring tube as an outer tube, the strength of the spring tube is higher than that of a plastic outer tube of an existing cold snare, which is helpful for the loop to cut when grabbing large polyps.

Abstract: Three-arm clamp includes: clamping assembly and releasing member connected to each other, clamping assembly includes fixed arm, and two movable arms respectively rotatably connected to fixed arm by hinge pin; the proximal end of each movable arm is provided with first sliding slot, and sliding pin is slidably arranged in first sliding slot; the proximal end of fixed arm is provided with inner cavity, and releasing member is inserted into inner cavity and connected to sliding pin; the proximal end of each movable arm is provided with elastic sheet; movable arms and fixed arm are closed by clamping, and elastic sheets are folded in inner cavity, in radial direction of fixed arm, from connecting end to free end and abut against releasing member; and releasing member is separated from movable arms, and the free end of each elastic sheet elastically abuts against inner wall of inner cavity.

Abstract: Provided are a pressure-pump cartridge and a pressure pump, where the pressure-pump cartridge includes a cylinder, where the cylinder has a first chamber, a piston chamber and a second chamber hat are in communication in sequence, and the piston chamber is used for being in sealing fit with a piston. An end of the first chamber remote from the piston chamber is provided with a first opening allowing entry of the piston, and during installation, the piston enters the first chamber by the first opening and enters the piston chamber after passing through the first chamber, and meanwhile, the first chamber is configured to be in a clearance fit with the piston, such that the size of the first chamber is larger than that of the piston.

Abstract: A tissue clamping and closing device for passing through an endoscope, including: a clamp having at least two clamp legs; a control line separably connected to a through hole at the proximal end of the clamp; an axial sheath arranged around the control line; a sleeve configured to accommodate the proximal end portion of the clamp and separably connected to the distal end of the axial sheath; a retainer configured to retain a connection between the sleeve and the axial sheath and implement the separation of the sleeve from the axial sheath through the deformation of the retainer under the action of the control line a control mechanism connected to the proximal end of the axial sheath and the proximal end of the control line; wherein the control line can control the at least two clamp legs of the clamp to be opened or closed through the control mechanism.

Abstract: The present invention provides a medical pressurization control device, comprising an outer tube and a threaded push rod inside the outer tube. A movable caliper comprising two arms, a caliper control member connected to the movable caliper, and an operating member connected to the caliper control member are provided in the outer tube; when the operating member moves from a second position to a first position, the operating member drives the caliper control member to move to a locking position, so as to push the two arms of the movable caliper to hold the threaded push rod for locking the threaded push rod; when the operating member moves from the first position to the second position, the operating member drives the caliper control member to move to a release position, so as to push the two arms of the movable caliper to release the threaded push rod for unlocking the threaded push rod.

Abstract: A slide slot type multi-arm clamp includes a handle, a catheter, a clamping portion, a spring tube and a control line. In practical applications, a surgical operator applies an axial thrust and a pulling force to the handle to drive the control line to move, so as to open/close and lock the clamping portion. Moreover, side clamp arms and a clamp base in the clamping portion can be easily separated from the catheter or the spring tube to stay in a human body so as to achieve the functions of hemostasis and tissue suture. The side slot type multi-arm clamp can achieve the effect of minimizing the length of the instrument retained in the human body by the cooperation between the side clamp arms and the clamp base.

Abstract: An intraluminal stent (1) and a preparation method therefor are provided. The intraluminal stent (1) includes at least one sub-stent. The sub-stent includes at least a first wire (4) extending along a first spiral direction and at least a second wire (5) extending along a second spiral direction, and the first wire (4) and the second wire (5) extend in different directions to form several wire intersection points. The intraluminal stent (1) has several wrapped portions (2) to wrap two corresponding wire tail ends. A wrapping connector (3) is disposed at a periphery of the wrapped portion (2). Two end portions of the wrapping connector (3) are firmly connected to regions corresponding to two ends of the wrapped portion (2). The two wire tail ends of the wrapped portions (2) are wrapped by using the wrapping connector (3). The stent (1) is less harmful to intraluminal tissues and a relatively strong tensile resistance.

Abstract: Provided is a release device for medical tissue clips, including an outer tube provided with a release member, a control wire, and at least one tissue clip; wherein the release member is connected to the distal end of the control wire; the at least one tissue clip is movably connected to the release member and the control wire; the tissue clip includes a clip base and a clip piece which is movably disposed inside the clip base; the tissue clip is in a locked state when the clip piece is retreated to the proximal end, and in an opened state when the clip piece moves forwards to the distal end; the clip base includes an elastic member which is in a compressed state when being located in the outer tube and in an opened state upon detachment from the outer tube to abut against an end of the outer tube.

Abstract: An anastomosis clamp (1) and a delivery system thereof, where the anastomosis clamp (1) includes inner lancets (102, 602), round corners (103, 603), and outer rings (101, 601) that are sequentially connected; the delivery system may be used in cooperation with the anastomosis clamp (1); and the delivery system includes a distal end (2), a middle flexible sheath (3), and a handle (4).

Abstract: The present disclosure provides an endoscopic ultrasound needle device and a method for operating the same. The endoscopic ultrasound needle device includes a first needle defining a first bore; a second needle located in the first bore, wherein the second needle is adapted to move or reciprocate within the first bore in response to a manipulation of a component located adjacent or on a handle of the device; and a first cut edge on the first needle, defining an orifice or opening in open communication with the first bore, wherein the first cut edge cooperates with at least a portion of the second needle to cut or slice the tissue, during the second needle moves or reciprocates within the first bore, relative to the first needle, in the extension direction of the first bore, which has high tissue sampling efficiency.

Abstract: The present invention provides a medical pressurization control device, comprising an outer tube and a threaded push rod inside the outer tube. A movable caliper comprising two arms, a caliper control member connected to the movable caliper, and an operating member connected to the caliper control member are provided in the outer tube; when the operating member moves from a second position to a first position, the operating member drives the caliper control member to move to a locking position, so as to push the two arms of the movable caliper to hold the threaded push rod for locking the threaded push rod; when the operating member moves from the first position to the second position, the operating member drives the caliper control member to move to a release position, so as to push the two arms of the movable caliper to release the threaded push rod for unlocking the threaded push rod.

Abstract: Provided is a release device for medical tissue clips, including an outer tube provided with a release member, a control wire, and at least one tissue clip; wherein the release member is connected to the distal end of the control wire; the at least one tissue clip is movably connected to the release member and the control wire; the tissue clip includes a clip base and a clip piece which is movably disposed inside the clip base; the tissue clip is in a locked state when the clip piece is retreated to the proximal end, and in an opened state when the clip piece moves forwards to the distal end; the clip base includes an elastic member which is in a compressed state when being located in the outer tube and in an opened state upon detachment from the outer tube to abut against an end of the outer tube.

Abstract: A hemostatic clip comprises a clamping assembly and a clip base. The clamping assembly comprises a clip body and a steel wire buckle sequentially connected; a fixed hinge pin is arranged at the front end of the clip base, the clip body consists of two clamping arms, the tail ends of the two clamping arms are connected through a movable hinge pin, the middle part of each of the two clamping arms is provided with a chute, the fixed hinge pin penetrates through the chutes, and the two clamping arms reciprocate along the chutes so that the clip body can be opened and closed; a bent structure is arranged at the tail end of each chute; and when the clamping arms move to make the fixed hinge pin be located in the bent structures, the two clamping arms are located in the locked and closed position.

Abstract: A hemostatic clip comprises a clamping assembly and a clip base. The clamping assembly comprises a clip body and a steel wire buckle sequentially connected; a fixed hinge pin is arranged at the front end of the clip base, the clip body consists of two clamping arms, the tail ends of the two clamping arms are connected through a movable hinge pin, the middle part of each of the two clamping arms is provided with a chute, the fixed hinge pin penetrates through the chutes, and the two clamping arms reciprocate along the chutes so that the clip body can be opened and closed; a bent structure is arranged at the tail end of each chute; and when the clamping arms move to make the fixed hinge pin be located in the bent structures, the two clamping arms are located in the locked and closed position.