Abstract: Disclosed are a class of compounds having a new structure as an ATR inhibitor, and a stereoisomer, an optical isomer, a pharmaceutical salt, a prodrug and a solvate thereof. An in-vitro enzyme inhibitory activity study shows that the compounds have a strong inhibitory effect on an ATR enzyme, and can be used as prospecting compounds for treating ATR-mediated diseases.

Abstract: The present disclosure relates to compounds, compositions, and methods for the treatment of primary hyperoxaluria type 1 and recurrent kidney stone formers. The present disclosure is directed to novel substituted heterocyclic carboxylate compounds and methods for their preparation and use as therapeutic or prophylactic agents. In particular, the present disclosure provides novel inhibitors of human glycolate oxidase enzyme, pharmaceutical compositions containing such compounds, and methods for using these compounds to treat primary hyperoxaluria type 1 and recurrent kidney stone formers.

Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.

Abstract: The present disclosure provides a method, apparatus, medium and device for extracting a river drying-up region and frequency, and belongs to the technical field of remote sensing. The method for extracting a river drying-up region and frequency can be applied to efficiently acquiring river drying-up information for a long time within the large spatial region. With the inverse normalized difference water index (iNDWI) and the maximum value composite (MVC) method for the remote sensing images, the present disclosure omits the troublesome step of separately extracting a river range for each image in the conventional method. In addition, the present disclosure quickly obtains the drying-up frequency by counting the total number of available images and the number of non-water images at the same pixel position, and yields a greater efficiency for extracting the river drying-up region and frequency.

Abstract: Embodiments of the present application provide a display apparatus. The display apparatus includes a display and a controller. The controller is configured to: while the display apparatus is working under a first signal source, present first content from the first signal source; in response to a selection of the video recording application, start a video recording process associated with the first content and monitor recording duration of the video recording process; generate a recording state control with foreground display permission while the display apparatus is connected with any signal source; in response to a source switch request, switch from the first signal source to a second signal source according to the source switch request, present second content from the second signal source, and control the video recording process to run in the background; and present the recording state control on a display interface with the second content.

Abstract: Embodiments of the present application provide a display apparatus. The display apparatus includes a display and a controller. The controller is configured to: while the display apparatus is working under a first signal source, present first content from the first signal source; in response to a selection of the video recording application, start a video recording process associated with the first content and monitor recording duration of the video recording process; generate a recording state control with foreground display permission while the display apparatus is connected with any signal source; in response to a source switch request, switch from the first signal source to a second signal source according to the source switch request, present second content from the second signal source, and control the video recording process to run in the background; and present the recording state control on a display interface with the second content.

Abstract: The present invention relates to polymeric materials and liners for a container adapted to hold a food and/or beverage container in a cooled condition. In certain aspects, it includes (a) at least one co-polymeric chain which imparts plastic characteristics to said liner material; and (b) one or more rubber moieties grafted to and/or dispersed in said at least one first co-polymeric chain, wherein said one or more rubber moieties comprises at least about 30% by weight of said liner. In other aspects, it includes (a) at least one co-polymeric chain which imparts plastic characteristics to said liner material; and (b) one or more rubber moieties grafted to and/or dispersed in said at least one co-polymeric chain, wherein said one or more rubber moieties are present in the liner in an amount effective to ensure that said liner exhibits no stress cracking after one thermal test cycle.

Abstract: Polymeric fibers may be tested for optical properties; such as transparency in a manner that provides reproducible test results. A holder be used that is configured to hold polymeric fibers in a stacked, single file manner in which the polymeric fibers are held closely together. The fibers may be tested using an optical apparatus employing an integrating sphere.

Abstract: The examples of the present invention disclose an anti-interference method and device in a common-frequency networking mobile communication system. The method includes: creating a candidate cell list according to probability that each adjacent cell of a current cell interferes with the current cell; selecting a selected cell list from the candidate cell list according to the probability; performing channel estimation for adjacent cells in the selected cell list, obtaining current signal power of each adjacent cell in the selected cell list according to a channel estimation result, and selecting a detected cell list from the selected cell list according to the signal power; and performing joint detection for adjacent cells in the detected cell list to eliminate interference of the adjacent cells in the detected cell list on the current cell.

Abstract: Disclosed are a data processing method and device for an essential factor lost score. The method comprises: determining, according to a representative KPI lost score, contributions of a representative KPI to a QoE lost score; searching the correspondence between the representative KPI and essential factors, and determining contributions of the essential factors, corresponding to the representative KPI, to the QoE lost score; making statistics on contributions of essential factors, corresponding to all representative KPI lost scores, to the QoE lost score; and summating the contributions of the same essential factor to the QoE lost score, so as to obtain the lost score of the same essential factor.

Abstract: A method includes: sending, by an RNC, MBMS data to base stations of the target cells or sectors, distributing the same time and frequency resources, scrambling code and midamble to the cells or sectors to transmit the MBMS data, sending information of the distributed resources, scrambling code and midamble to the base stations and UEs of the target cells or sectors; and rotating, by each of the base stations, the MBMS burst signal to be sent by a random phase, sending the rotated signal to the UE using time and frequency resources distributed by RNC. A system includes an RNC, base stations and a UE, and each of the base stations includes a phase processing module and a signal sending module.

Abstract: A method for detecting pilot sequence signal includes: when the service data signal in the received signal is confirmed to be right, the said service data signal is extracted from the received signal, wherein, the service data signal and the pilot sequence signal in the received signal are located in the same slot; the pilot sequence signal is obtained from the received signal having been extracted the service data signal. At the same time, a communication device and a communication system are provided. The interference of pilot sequence signal made by the service data signal can be restrained, the detecting performance of the pilot sequence can be enhanced by using the present invention.

Abstract: The examples of the present invention disclose an anti-interference method and device in a common-frequency networking mobile communication system. The method includes: creating a candidate cell list according to probability that each adjacent cell of a current cell interferes with the current cell; selecting a selected cell list from the candidate cell list according to the probability; performing channel estimation for adjacent cells in the selected cell list, obtaining current signal power of each adjacent cell in the selected cell list according to a channel estimation result, and selecting a detected cell list from the selected cell list according to the signal power; and performing joint detection for adjacent cells in the detected cell list to eliminate interference of the adjacent cells in the detected cell list on the current cell.

Abstract: A method for detecting pilot sequence signal includes: when the service data signal in the received signal is confirmed to be right, the said service data signal is extracted from the received signal, wherein, the service data signal and the pilot sequence signal in the received signal are located in the same slot; the pilot sequence signal is obtained from the received signal having been extracted the service data signal. At the same time, a communication device and a communication system are provided. The interference of pilot sequence signal made by the service data signal can be restrained, the detecting performance of the pilot sequence can be enhanced by using the present invention.

Abstract: A method, system and base station for transmitting MBMS in a single frequency network are provided. The method includes: sending, by an RNC, MBMS data to base stations of the target cells or sectors, distributing the same time and frequency resources, scrambling code and midamble to the cells or sectors to transmit the MBMS data, sending information of the distributed resources, scrambling code and midamble to the base stations and UEs of the target cells or sectors; and rotating, by each of the base stations, the MBMS burst signal to be sent by a random phase, sending the rotated signal to the UE using time and frequency resources distributed by RNC. The system includes an RNC, base stations and a UE, and each of the base stations includes a phase processing module and a signal sending module.