Patents by Inventor Hongying Duan Holdsworth

Hongying Duan Holdsworth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GLYCAN-MASKED ENGINEERED OUTER DOMAINS OF HIV-1 GP120 AND THEIR USE
    Publication number: 20220152194
    Abstract: Embodiments of immunogens based on the outer domain of HIV-1 gp120 and methods of their use and production are disclosed. Nucleic acid molecules encoding the immunogens are also provided. In several embodiments, the immunogens can be used to prime an immune response to gp120 in a subject, for example, to treat or prevent an HIV-1 infection in the subject.
    Type: Application
    Filed: January 28, 2022
    Publication date: May 19, 2022
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Servic
    Inventors: Xuejun Chen, Jeffrey Boyington, Hongying Duan Holdsworth, Cheng Cheng, John R. Mascola
  • Glycan-masked engineered outer domains of HIV-1 gp120 and their use
    Patent number: 11235056
    Abstract: Embodiments of immunogens based on the outer domain of HIV-1 gp120 and methods of their use and production are disclosed. Nucleic acid molecules encoding the immunogens are also provided. In several embodiments, the immunogens can be used to prime an immune response to gp120 in a subject, for example, to treat or prevent an HIV-1 infection in the subject.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: February 1, 2022
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Xuejun Chen, Jeffrey Boyington, Hongying Duan Holdsworth, Cheng Cheng, John R. Mascola