Patents by Inventor HongYing Yun

HongYing Yun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzazepine dicarboxamide compounds
    Patent number: 9597333
    Abstract: This invention relates to novel benzazepine dicarboxamide compounds of the formula wherein R1 to R4 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are TLR agonists and may therefore be useful as medicaments for the treatment of diseases such as cancer, autoimmune diseases, inflammation, sepsis, allergy, asthma, graft rejection, graft-versus-host disease, immunodeficiencies, and infectious diseases.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: March 21, 2017
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Sabine Hoves, Lisha Wang, Hongying Yun, Weixing Zhang, Wei Zhu
  • Benzazepine Dicarboxamide Compounds
    Publication number: 20170014423
    Abstract: This invention relates to novel benzazepine dicarboxamide compounds of the formula wherein R1 to R4 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are TLR agonists and may therefore be useful as medicaments for the treatment of diseases such as cancer, autoimmune diseases, inflammation, sepsis, allergy, asthma, graft rejection, graft-versus-host disease, immunodeficiencies, and infectious diseases.
    Type: Application
    Filed: September 28, 2016
    Publication date: January 19, 2017
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Sabine Hoves, Lisha Wang, Hongying Yun, Weixing Zhang, Wei Zhu
  • Novel Imidazoles for the Treatment and Prophylaxis of Respiratory Syncytial Virus Infection
    Publication number: 20160326148
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3 and Q are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: July 21, 2016
    Publication date: November 10, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Lu GAO, Chungen LIANG, Lisha WANG, Hongying YUN
  • NOVEL 3-SUBSTITUTED 5-AMINO-6H-THIAZOLO[4,5-D]PYRIMIDINE-2, 7-DIONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION
    Publication number: 20160326209
    Abstract: The present invention relates to compounds of formula (I), wherein R1, R2 and R3 are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: July 11, 2016
    Publication date: November 10, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Dongdong Chen, Song Feng, Lu Gao, Chao Li, Baoxia Wang, Lisha Wang, Hongying Yun, Xiufang Zheng
  • Novel Sulfonimidoylpurinone Compounds and Derivatives for the Treatment and Prophylaxis of Virus Infection
    Publication number: 20160326177
    Abstract: The present invention relates to compounds of formula (I), wherein R1, R2 and R3 are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: May 6, 2016
    Publication date: November 10, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Chungen Liang, Jianping Wang, Kun Miao, Hongying Yun, Xiufang Zheng
  • Benzazepine dicarboxamide compounds
    Patent number: 9475775
    Abstract: This invention relates to novel benzazepine dicarboxamide compounds of the formula wherein R1 to R4 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are TLR agonists and may therefore be useful as medicaments for the treatment of diseases such as cancer, autoimmune diseases, inflammation, sepsis, allergy, asthma, graft rejection, graft-versus-host disease, immunodeficiencies, and infectious diseases.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: October 25, 2016
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Sabine Hoves, Lisha Wang, Hongying Yun, Weixing Zhang, Wei Zhu
  • 3-substituted 5-amino-6H-thiazolo[4,5-D]pyrimidine-2,7-dione compounds for the treatment and prophylaxis of virus infection
    Patent number: 9441008
    Abstract: The present invention relates to compounds of formula (I), wherein R1, R2 and R3 are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: September 13, 2016
    Assignee: Hoffmann-LA Roche Inc.
    Inventors: Dongdong Chen, Song Feng, Lu Gao, Chao Li, Baoxia Wang, Lisha Wang, Hongying Yun, Xiufang Zheng
  • Benzazepine Dicarboxamide Compounds
    Publication number: 20160257653
    Abstract: This invention relates to novel benzazepine dicarboxamide compounds of the formula wherein R1 to R4 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are TLR agonists and may therefore be useful as medicaments for the treatment of diseases such as cancer, autoimmune diseases, inflammation, sepsis, allergy, asthma, graft rejection, graft-versus-host disease, immunodeficiencies, and infectious diseases.
    Type: Application
    Filed: March 4, 2016
    Publication date: September 8, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Sabine Hoves, Lisha Wang, Hongying Yun, Weixing Zhang, Wei Zhu
  • NOVEL AZA-OXO-INDOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION
    Publication number: 20160229853
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, W and X are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: April 8, 2016
    Publication date: August 11, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Lu GAO, Lei GUO, Chungen LIANG, Baoxia WANG, Lisha WANG, Hongying YUN, Weixing ZHANG, Xiufang ZHENG
  • Novel indazoles for the treatment and prophylaxis of respiratory syncytial virus infection
    Publication number: 20160200741
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R7, A1, A2 and A3 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: November 18, 2015
    Publication date: July 14, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Song FENG, LU GAO, Di HONG, Lisha WANG, Hongying YUN, Shu-Hai ZHAO
  • NOVEL 3-SUBSTITUTED 5-AMINO-6H-THIAZOLO[4,5-D]PYRIMIDINE-2,7-DIONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION
    Publication number: 20160194350
    Abstract: The present invention relates to compounds of formula (I), wherein R1, R2 and R3 are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: December 3, 2015
    Publication date: July 7, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Dongdong Chen, Song Feng, Lu Gao, Chao Li, Baoxia Wang, Lisha Wang, Hongying Yun, Xiufang Zheng
  • NOVEL AZA-OXO-INDOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION
    Publication number: 20160159794
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, W and X are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: February 11, 2016
    Publication date: June 9, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Lisha Wang, Hongying Yun, Weixing Zhang, Xiufang Zheng
  • NOVEL AZA-OXO-INDOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION
    Publication number: 20160068531
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R6, W1, W2, W3, A and X are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: November 16, 2015
    Publication date: March 10, 2016
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Lisha WANG, Lu GAO, Mengwei HUANG, Lei GUO, Chungen LIANG, Wei ZHU, Song FENG, Xiufang ZHENG, Weixing ZHANG, Guolong WU, Baoxia WANG, Hongying YUN
  • Indazoles for the treatment and prophylaxis of respiratory syncytial virus infection
    Patent number: 9206191
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R7, A1, A2 and A3 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: December 8, 2015
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Song Feng, Lu Gao, Di Hong, Lisha Wang, Hongying Yun, Shu-Hai Zhao
  • Novel indazoles for the treatment and prophylaxis of respiratory syncytial virus infection
    Publication number: 20150158879
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R7, A1, A2 and A3 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: January 9, 2015
    Publication date: June 11, 2015
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Song Feng, Lu Gao, Di Hong, Lisha Wang, Hongying Yun, Shu-Hai Zhao
  • Compounds for the treatment and prophylaxis of Respiratory Syncytial Virus disease
    Patent number: 8871756
    Abstract: A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R10, A, Q, X and Y are as defined in the specification and claims, and their use as a pharmaceutical for the treatment or prophylaxis of respiratory syncytial virus disease.
    Type: Grant
    Filed: July 30, 2012
    Date of Patent: October 28, 2014
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Li Chen, Lichun Feng, Song Feng, Lu Gao, Tao Guo, Mengwei Huang, Chungen Liang, Yongfu Liu, Lisha Wang, Jason Christopher Wong, Jim Zhen Wu, Xihan Wu, Hongying Yun, Xiufang Zheng
  • Tetrahydroquinoline derivatives
    Patent number: 8809369
    Abstract: The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein R1 to R8, A1 to A3 have the are as described herein and compositions including the compounds.
    Type: Grant
    Filed: January 19, 2012
    Date of Patent: August 19, 2014
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Lichun Feng, Mengwei Huang, Yongfu Liu, Guolong Wu, Shixiang Yan, Hongying Yun, Mingwei Zhou
  • Naphthylacetic acids
    Patent number: 8642629
    Abstract: The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein W, X, Y, and R1-R7 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
    Type: Grant
    Filed: November 9, 2009
    Date of Patent: February 4, 2014
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Li Chen, Fariborz Firooznia, Paul Gillespie, Yun He, Tai-An Lin, Eric Mertz, Sung-Sau So, HongYing Yun, Zhenshan Zhang
  • Compounds for the treatment and prophylaxis of respiratory syncytial virus disease
    Patent number: 8604019
    Abstract: The invention relates to the compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2 and X are as defined in the description and claims, which are useful for the treatment or prophylaxis of RSV infection.
    Type: Grant
    Filed: October 10, 2012
    Date of Patent: December 10, 2013
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Chungen Liang, Lisha Wang, Hongying Yun, Xiufang Zheng
  • Tetrahydro-quinoline derivatives
    Patent number: 8592594
    Abstract: A compound of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein A1 to A3 and R1 to R10 have the significance given in claim 1, can be used as a medicament. These compounds are useful in the treatment or prophylaxis of diseases that are related to AMPK regulation, such as obesity, dyslipidemia, hyperglycemia, type 1 or type 2 diabetes and cancers.
    Type: Grant
    Filed: June 27, 2011
    Date of Patent: November 26, 2013
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Li Chen, Lichun Feng, Yun He, Mengwei Huang, Yongfu Liu, Hongying Yun, Mingwei Zhou