Patents by Inventor Hongyu Luo
Hongyu Luo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230112511Abstract: The present invention provides a liquid bandage containing peptide anti-inflammatory active ingredient and a preparation method thereof, which relates to the technical field of medical materials. The liquid bandage comprises film-forming agents; one or more plasticizers, comprising glycerin; one or more anti-inflammatory substances, comprising oligopeptide with an amino acid sequence of Leu-Leu-Phe-Thr-Thr-Gln; and solvent, comprising deionized water. The liquid bandage can promote the expression of interleukin 10 (IL-10) and inhibit the expressions of interleukin 6 (IL-6) and tumor necrosis factor (TNF-?). Peptide anti-inflammatory active ingredient can produce good anti-inflammatory activity. Further, the liquid bandage can enhance the close contact between gel and the injured skin surface, increase the cleanliness of the wound surface, and can increase a clearance rate of inflammatory cells.Type: ApplicationFiled: November 9, 2022Publication date: April 13, 2023Applicant: ZHEJIANG OCEAN UNIVERSITYInventors: HONGYU LUO, XINWEI YU, ZHIGAO WANG, JU HUANG, PENG GAO, CHONG YI
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Publication number: 20230004862Abstract: The technical solution relates to the field of artificial intelligence technologies, such as machine learning technologies, natural language processing technologies, or the like. A plurality of training samples are collected, each of the plurality of training samples includes information of a known training target protein, information of two training drugs, and a real difference between affinities of the two training drugs for the known training target. The ranking learning model is trained with the plurality of training samples, such that the ranking learning model learns a capability of predicting a magnitude relationship between the affinities of the two training drugs for the known training target protein in each of the plurality of training samples.Type: ApplicationFiled: November 30, 2021Publication date: January 5, 2023Applicant: BEIJING BAIDU NETCOM SCIENCE TECHNOLOGY CO., LTD.Inventors: Yingfei XIANG, Hongyu LUO, Xiaomin FANG, Fan WANG
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Publication number: 20210093748Abstract: The present invention provides a liquid band-aid containing peptide anti-inflammatory active ingredient and a preparation method thereof, which belong to the technical field of medical materials. The liquid band-aid includes film-forming agent, plasticizer, anti-inflammatory substance, and solvent, where the plasticizer includes glycerin, the solvent includes deionized water, and the anti-inflammatory substance includes high F-value oligopeptide with an amino acid sequence of Leu-Leu-Phe-Thr-Thr-Gln and a molecular weight of 736.52 Da. The liquid band-aid can promote the expression of interleukin 10 (IL-10) and inhibit the expressions of cytokine interleukin 6 (IL-6) and tumor necrosis factor (TNF-?), and thus have good anti-inflammatory activity. The liquid band-aid further enhances the close contact between gel and an injured skin surface, increases the cleanliness of a wound surface, and improves the clearance rate of inflammatory cells.Type: ApplicationFiled: September 26, 2020Publication date: April 1, 2021Inventors: HONGYU LUO, XINWEI YU, ZHIGAO WANG, JU HUANG, PENG GAO, CHONG YI
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Patent number: 9039921Abstract: A method to produce low-temperature sinterable powders which are then subsequently used to fabricate freestanding piezoelectric films with very large electric-field-enhanced piezoelectric response is provided. The ?d31 coefficient for PMN-PT layers can be as high as 2000 pm/V, larger than that of commercial single crystalline PMN-PT bulk materials, at 10 kV/cm (or 20 V over the 20-micron film thickness). In contrast to single crystals, the polycrystalline freestanding films are easy to fabricate and can be made into any size. The films are also easily miniaturized. The method can be applied to nearly any piezoelectric material.Type: GrantFiled: May 20, 2010Date of Patent: May 26, 2015Assignee: Drexel UniversityInventors: Wei-Heng Shih, Hongyu Luo, Christian Martorano, Wan Y. Shih
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Patent number: 9018147Abstract: Methods of making particulates for use in a subterranean application comprising: providing particulates of a settable composition comprising a cementitious material, a filler material, and an activator of the cementitious material; and pre-curing the particulates until the particulates reach a crush strength of about 50 psi or greater; and curing the pre-cured particulates at a temperature in the range of about 230° F. to about 600° F., so that at least a portion of the particulates comprise a newly formed crystalline phase.Type: GrantFiled: March 12, 2012Date of Patent: April 28, 2015Assignee: Halliburton Energy Services, Inc.Inventors: Hongyu Luo, Lewis R. Norman, Ronald J. Powell, Rajesh K. Saini, Ashok K. Santra, Craig W. Roddy
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Patent number: 8936084Abstract: Methods of making a degradable ball composition comprising a carboxylic acid, a fatty alcohol, a fatty acid salt, a fatty ester, or a combination thereof comprising the steps of: forming a thermoplastic mass, and allowing the thermoplastic mass to cool as to form a degradable ball that is introduced in subterranean treatments by a carrier fluid.Type: GrantFiled: April 27, 2012Date of Patent: January 20, 2015Assignee: Halliburton Energy Services, Inc.Inventors: Hongyu Luo, Dwight D. Fulton
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Patent number: 8904853Abstract: Methods comprising: placing particulates in a test column; adding a fluid medium comprising a salt solution to the test column; placing the column under test conditions, wherein the test conditions comprise target temperature and target pressure; maintaining test conditions for a target test duration; and, analyzing the particulates. Some methods also measure a permeability value of the column after placing particulates in a test column and before placing the column under test conditions; continuously flow the salt solution through the particulates during the test; measure a permeability value after maintaining the test conditions for the target test duration; and, calculate a retained permeability value.Type: GrantFiled: March 27, 2012Date of Patent: December 9, 2014Assignee: Halliburton Energy Services, Inc.Inventors: Enrique A. Reyes, Jimmie D. Weaver, Richard D. Rickman, Hongyu Luo
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Patent number: 8757260Abstract: Methods and compositions that include a method of treating a subterranean formation comprising the steps of providing a carrier fluid comprising degradable balls that comprise a carboxylic acid, a fatty alcohol, a fatty acid salt, a fatty ester, a fatty acid salt, or a combination thereof, and introducing the carrier fluid to the subterranean formation during a treatment.Type: GrantFiled: February 11, 2009Date of Patent: June 24, 2014Assignee: Halliburton Energy Services, Inc.Inventors: Hongyu Luo, Dwight D. Fulton
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Publication number: 20140123739Abstract: Methods of testing brittle particulate materials are described. In a preferred embodiment, a method includes characterizing the particle disintegration or breakage after a sample of brittle particle material is treated with a fluid or chemical. The particle disintegration may be characterized with visual observation. Imaging, or particle size measurement methods. In, another preferred embodiment, a method includes crushing 100-200 particles of a brittle particulate material for statistical analysis of its mechanical property. Un yet another preferred embodiment, a method includes analyzing the results of single particle crush of a brittle particulate material with Weibull distribution and using the product of the Weibull modulus and characteristic property as a unified measure of the mechanical property of the brittle particulate material.Type: ApplicationFiled: September 25, 2013Publication date: May 8, 2014Inventor: Hongyu Luo
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Patent number: 8307897Abstract: Methods using diagenesis source material including the steps of providing a diagenesis source material in a subterranean formation and introducing a first plurality of particulates into the subterranean formation. The diagenesis source material then consolidates at least a portion of the first plurality of particulates into a pack in the subterranean formation.Type: GrantFiled: October 6, 2009Date of Patent: November 13, 2012Inventors: Enrique A. Reyes, Jimmie D. Weaver, Richard D. Rickman, Hongyu Luo
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Publication number: 20120214715Abstract: Methods of making a degradable ball composition comprising a carboxylic acid, a fatty alcohol, a fatty acid salt, a fatty ester, or a combination thereof comprising the steps of: forming a thermoplastic mass, and allowing the thermoplastic mass to cool as to form a degradable ball that is introduced in subterranean treatments by a carrier fluid.Type: ApplicationFiled: April 27, 2012Publication date: August 23, 2012Applicant: Halliburton Energy Services, Inc.Inventors: Hongyu Luo, Dwight D. Fulton
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Publication number: 20120180551Abstract: Methods comprising: placing particulates in a test column; adding a fluid medium comprising a salt solution to the test column; placing the column under test conditions, wherein the test conditions comprise target temperature and target pressure; maintaining test conditions for a target test duration; and, analyzing the particulates. Some methods also measure a permeability value of the column after placing particulates in a test column and before placing the column under test conditions; continuously flow the salt solution through the particulates during the test; measure a permeability value after maintaining the test conditions for the target test duration; and, calculate a retained permeability value.Type: ApplicationFiled: March 27, 2012Publication date: July 19, 2012Applicant: Halliburton Energy Services, Inc.Inventors: Enrique A. Reyes, Jimmie D. Weaver, Richard D. Rickman, Hongyu Luo
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Publication number: 20120167803Abstract: Methods of making particulates for use in a subterranean application comprising: providing particulates of a settable composition comprising a cementitious material, a filler material, and an activator of the cementitious material; and pre-curing the particulates until the particulates reach a crush strength of about 50 psi or greater; and curing the pre-cured particulates at a temperature in the range of about 230° F. to about 600° F., so that at least a portion of the particulates comprise a newly formed crystalline phase.Type: ApplicationFiled: March 12, 2012Publication date: July 5, 2012Applicant: HALLIBURTON ENERGY SERVICES, INC.Inventors: Hongyu Luo, Lewis R. Norman, Ronald J. Powell, Rajesh K. Saini, Ashok K. Santra, Craig W. Roddy
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Patent number: 8183186Abstract: Methods of making particulates for use in a subterranean application comprising: providing particulates of a settable composition comprising a cementitious material, a filler material, and an activator of the cementitious material; and pre-curing the particulates until the particulates reach a crush strength of about 50 psi or greater; and curing the pre-cured particulates at a temperature in the range of about 230° F. to about 600° F., so that at least a portion of the particulates comprise a newly formed crystalline phase.Type: GrantFiled: November 5, 2008Date of Patent: May 22, 2012Assignee: Halliburton Energy Services, Inc.Inventors: Hongyu Luo, Lewis R. Norman, Ronald J. Powell, Rajesh K. Saini, Ashok K. Santra, Craig W. Roddy
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Patent number: 8119576Abstract: Treatments and compounds useful in subterranean formations are discussed, with particular attention to those utilizing ceramic coated particulates. Certain embodiments pertain to particulates and particulate packs with ceramic coatings of subatomic thickness. Of these, certain methods may utilize ceramic coatings on particulates in a subterranean formation, certain methods may utilize ceramic coatings on particulate packs in a subatomic formation, and certain compounds may provide the features of both ceramic coatings and particulates.Type: GrantFiled: October 6, 2009Date of Patent: February 21, 2012Assignee: Halliburton Energy Services, Inc.Inventors: Enrique A. Reyes, Jimmie D. Weaver, Hongyu Luo
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Patent number: 8109335Abstract: Methods and compositions that include a method comprising: providing a treatment fluid comprising at least a plurality of degradable diverting agents that comprise at least one degradable material selected from the group consisting of a fatty alcohol, a fatty acid salt, a fatty ester, a proteinous material, and a combination thereof; and introducing the treatment fluid into a subterranean formation during a subterranean operation via a well bore.Type: GrantFiled: July 13, 2009Date of Patent: February 7, 2012Assignee: Halliburton Energy Services, Inc.Inventors: Hongyu Luo, Dwight D. Fulton
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Publication number: 20110253374Abstract: Treatments and compounds useful in subterranean formations are discussed, with particular attention to fracturing treatments where particulates and/or surfaces may be subject to water intrusion. Certain methods pertain to utilizing diagenesis source material to create porous structures in a subterranean formation. Such porous structures may be formed of consolidated particulates and/or diagenic product. Certain methods pertain to analyzing and/or quantifying the effects of the other methods disclosed herein.Type: ApplicationFiled: October 6, 2009Publication date: October 20, 2011Inventors: Enrique A. Reyes, Jimmie D. Weaver, Richard D. Rickman, Hongyu Luo
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Patent number: 8012582Abstract: A method of making a proppant is provided, wherein the method includes the steps of: (a) forming a particulate comprising: (i) a binder; and (ii) a filler; and (b) sintering the particulate to form a sintered proppant, wherein the sintered proppant comprises: (i) at least 20 wt % of alkaline earth oxide equivalent; and (ii) at least 20 wt % of silicon dioxide equivalent. A method of treating (e.g., fracturing) a subterranean formation is provided, the method including the steps of: (a) suspending the sintered proppant in a treatment fluid; and (b) introducing the sintered proppant into the subterranean formation. The sintered proppant is made with a raw material selected from the group consisting of: unhydrated cement, hydrated cement (e.g., construction cement or concrete waste), kiln dust, fly ash, limestone, lime, talc, olivine, dolomite, clay that contains a substantial concentration of alkaline earth oxide equivalent, and any combination thereof in any proportion.Type: GrantFiled: September 25, 2008Date of Patent: September 6, 2011Assignee: Halliburton Energy Services, Inc.Inventors: Hongyu Luo, Ashok Santra, Lewis R. Norman, Mark Parker, Ronald J. Powell, Rajesh K. Saini
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Publication number: 20110005761Abstract: Methods and compositions that include a method comprising: providing a treatment fluid comprising at least a plurality of degradable diverting agents that comprise at least one degradable material selected from the group consisting of a fatty alcohol, a fatty acid salt, a fatty ester, a proteinous material, and a combination thereof; and introducing the treatment fluid into a subterranean formation during a subterranean operation via a well bore.Type: ApplicationFiled: July 13, 2009Publication date: January 13, 2011Inventors: Hongyu Luo, Dwight D. Fulton
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Publication number: 20100224818Abstract: A method to produce low-temperature sinterable powders which are then subsequently used to fabricate freestanding piezoelectric films with very large electric-field-enhanced piezoelectric response is provided. The ?d31 coefficient for PMN-PT layers can be as high as 2000 pm/V, larger than that of commercial single crystalline PMN-PT bulk materials, at 10 kV/cm (or 20 V over the 20-micron film thickness). In contrast to single crystals, the polycrystalline freestanding films are easy to fabricate and can be made into any size. The films are also easily miniaturized. The method can be applied to nearly any piezoelectric material.Type: ApplicationFiled: May 20, 2010Publication date: September 9, 2010Applicant: DREXEL UNIVERSITYInventors: Wei-Heng Shih, Hongyu Luo, Christian Martorano, Wan Y. Shih