Abstract: An RNA delivery system for the treatment of Huntington's disease. The system comprises a viral vector, the viral vector carries RNA fragments capable of treating Huntington's disease, the viral vector is capable of enrichment in organ tissues of a host and endogenously and spontaneously forming a complex containing the RNA fragments capable of treating Huntington's disease in the organ tissues of the host, and the complex can deliver the RNA fragments into a target tissue to treat Huntington's disease. The safety and reliability of the RNA delivery system for the treatment of Huntington's disease have been fully verified. The system has good medicinal properties, strong versatility, and has economic benefits and application prospects.

Abstract: Provided are a gene circuit, an RNA delivery system and the use thereof. Specifically, the gene circuit comprises at least an RNA fragment capable of inhibiting gene expression and/or a targeting tag having a targeting function. The gene circuit can be delivered to a host, enriched in organ tissues of the host and self-assembled to form a complex structure, and inhibits gene expression by means of the RNA fragment, thereby treating diseases. The delivery system comprises the gene circuit and a delivery carrier capable of delivering the gene circuit to organ tissues of a host for enrichment. The provided gene circuit has a targeting function and a treatment function, can quickly and accurately reach target organs and target tissues to exert a treatment effect, and is highly efficient with good results. The safety and reliability of the provided RNA delivery system are fully verified, and the RNA delivery system has good druggability, high universality, and great economic benefits and application prospects.

Abstract: Provided are an RNA plasmid delivery system and an application thereof. The RNA plasmid delivery system comprises a plasmid carrying an RNA fragment required to be delivered; the plasmid can be enriched in an organ tissue of a host, and spontaneously forms an exosome containing the RNA fragment in the organ tissue of the host, and therefore can enter and be combined with a target tissue to deliver the RNA fragment into the target tissue. The RNA delivery system is safe, reliable, good in druggability, and strong in universality.

Abstract: Provided are a viral vector-based RNA delivery system and a use thereof. The RNA delivery system comprises a viral vector. The viral vector carries an RNA fragment needing to be delivered, and can be enriched in organ tissues of a host. In the host organ tissues, the viral vector can endogenously and spontaneously form a composite structure containing the RNA fragment. The composite structure can enter and bind to target tissues, and feed the RNA fragment into the target tissues. The viral vector has a targeting tag. The composite structure is an exosome. The viral vector RNA delivery system is safe and reliable, and has good druggability and high universality.

Abstract: A ball bearing includes an inner ring (1), an outer ring (2), and a ball (3). The inner ring (1) has an inner ring groove curvature radius Ri. The outer ring (2) has an outer ring groove curvature radius Re. The ball (3) has a ball diameter Dw. The ratio of the outer ring groove curvature radius Re to the ball diameter Dw satisfies: Re/Dw?0.5275; and/or the ratio of inner ring groove curvature radius Ri to the ball diameter Dw satisfies: 0.5175?Ri/Dw?0.55. The ball bearing may be accommodated in a housing, thereby forming a ball bearing assembly.

Abstract: The application discloses an electrode having polarity capable of being reversed and use thereof. The electrode includes a substrate comprising a metal or an alloy thereof; an intermediate layer arranged on the substrate and comprising a platinum group metal and a platinum group metal oxide; and a catalytic layer arranged on the intermediate layer and comprising a mixed metal oxide. The electrode may be used as an electrode for electrolysis, electrodialysis or electroplating. The electrode can simultaneously meet the working environment requirements of the cathode and the anode, which improves the environmental tolerance and realizes the protection of the substrate; and can carry out polarity reversal to clean deposits on the surface of the electrode quickly and efficiently.

Abstract: The invention provides an electronic device, a PCB and an electric tool; comprises a main body, a first electric connecting part, a variable resistor, a speed regulating contact, a reversing electric connecting part, a reversing contact, a speed regulating handle and a reversing handle, the first electric connecting part is fixedly connected with the main body, and one end of the first electric connecting part is exposed out of the main body; one end of the speed regulating handle is of a cylindrical structure, the end part of the speed regulating handle is provided with an opening, one end of the main body is provided with a column, the opening end of the speed regulating handle is movably sleeved on the column through an elastic piece and forms a first space with the main body; the speed regulating contact and the variable resistor are arranged in the first space.

Abstract: The invention provides an electronic device, a PCB and an electric tool; the electronic device comprises a main body, a first electric connecting part, a variable resistor, a speed regulating contact, a reversing electric connecting part, a reversing contact, a speed regulating handle and a reversing handle, the first electric connecting part is connected with the main body in a melt adhesive curing mode, and one end of the first electric connecting part is exposed out of the main body; the speed regulating handle and the main body form a first space, the speed regulating contact and the variable resistor are arranged in the first space, and under the drive of the speed regulating handle, the speed regulating contact and the variable resistor relatively slide; under the driving of the reversing handle, the reversing contact and the reversing electric connecting part relatively slide for reversing.

Abstract: The invention is suitable for the technical field of electronic circuits, and provides an electronic switch module and an electric tool. The electronic switch module comprises a variable resistor and a first resistor, wherein the variable resistor and the first resistor form a voltage-dividing resistor unit, and the output end of the module is arranged on a connecting line between the variable resistor and the first resistor; one end of the voltage-dividing resistor unit is connected with a power supply, and the other end is grounded; the variable resistor comprises a plurality of second resistors with different resistance values, a conductive member, a first end and a resistance value adjusting member. When the resistance adjusting member slides along the conducting member, the two second resistors provide three different resistance values, so that the loss of the resistors is reduced, and the lightweight design of the product is facilitated.

Abstract: The invention provides an electronic device, a PCB and an electric tool; comprises a main body, a first electric connecting part, a variable resistor, a speed regulating contact, a reversing electric connecting part, a reversing contact, a speed regulating handle and a reversing handle, the first electric connecting part is fixedly connected with the main body, and one end of the first electric connecting part is exposed out of the main body; one end of the speed regulating handle is of a cylindrical structure, the end part of the speed regulating handle is provided with an opening, one end of the main body is provided with a column, the opening end of the speed regulating handle is movably sleeved on the column through an elastic piece and forms a first space with the main body; the speed regulating contact and the variable resistor are arranged in the first space.

Abstract: The present invention includes novel RAD51 inhibitors. The compounds of the invention may be useful in preventing or treating cancer in a subject in need thereof. The present invention also includes methods of preventing or treating cancer in a subject in need thereof by administering to the subject a therapeutically effective amount of a compound of the invention.

Abstract: The present invention includes novel RAD51 inhibitors. The compounds of the invention may be useful in preventing or treating cancer in a subject in need thereof. The present invention also includes methods of preventing or treating cancer in a subject in need thereof by administering to the subject a therapeutically effective amount of a compound of the invention.

Abstract: The present invention includes novel RAD51 inhibitors. The compounds of the invention may be useful in preventing or treating cancer in a subject in need thereof. The present invention also includes methods of preventing or treating cancer in a subject in need thereof by administering to the subject a therapeutically effective amount of a compound of the invention.

Abstract: The present invention includes novel RAD51 inhibitors. The compounds of the invention may be useful in preventing or treating cancer in a subject in need thereof. The present invention also includes methods of preventing or treating cancer in a subject in need thereof by administering to the subject a therapeutically effective amount of a compound of the invention.

Abstract: Provided herein are functionalized pegylated cyanine compounds containing a reactive group suitable for labeling a biomolecule or pharmaceutical compositions and methods of use thereof. In one embodiment, the compounds are based on formula I shown below. In other embodiments, the compounds can be pegylated at one or more of the following locations R1, R4, R6, R9, or L.

Abstract: Provided herein are functionalized pegylated cyanine compounds containing a reactive group suitable for labeling a biomolecule or pharmaceutical compositions and methods of use thereof. In one embodiment, the compounds are based on formula I shown below. In other embodiments, the compounds can be pegylated at one or more of the following locations R1, R4, R6, R9, or L.

Abstract: In one non-limiting, exemplary embodiment, a method includes: receiving radio resource control signaling with a user equipment, wherein the radio resource control signaling is indicative of at least one frequency sub-band to be measured by the user equipment for a particular cell in a manner transparent to at least one of an interference control scheme and a handover scheme implemented for the cell; performing at least one measurement of the at least one frequency sub-band; and reporting information descriptive of the at least one measurement.

Abstract: Apparatus and method for handing over, at a time instance, a first low power radio frequency transceiver participating in a first network of low power radio frequency transceivers using first network parameter(s) and controlled by a first master transceiver from the first network to a second network of low power radio frequency transceivers using second network parameter(s) and controlled by a second master transceiver. An indication of the time instance is sent to the first low power radio frequency transceiver. An indication of the time instance is also sent to the second master transceiver. An indication of the second network parameter(s) is sent to the first low power radio frequency transceiver. The first transceiver switches from using the first network parameter(s) to using the second network parameter(s) at time the time instance. The second master transceiver polls the first transceiver at the time instance using the second network parameters.

Abstract: A system and method for controlling base stations for multimedia broadcast communications. In one embodiment, a base station includes a reporting subsystem configured to broadcast at least one of a counting report request and a channel quality indictor report request to user equipment in a service area thereof. The reporting subsystem is also configured to process at least one of a counting report and a channel quality indicator report received from the user equipment and provide an activity status report therefrom. The base station also includes a dynamic single frequency network subsystem configured to determine to provide multimedia broadcast and multicast services in the service area thereof as a function of an activity status report from another base station.

Abstract: In one non-limiting, exemplary embodiment, a method includes: receiving radio resource control signaling with a user equipment, wherein the radio resource control signaling is indicative of at least one frequency sub-band to be measured by the user equipment for a particular cell in a manner transparent to at least one of an interference control scheme and a handover scheme implemented for the cell; performing at least one measurement of the at least one frequency sub-band; and reporting information descriptive of the at least one measurement.