Patents by Inventor Hongzhan Xu

Hongzhan Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RECOMBINANT VECTOR AND USE IN GENE THERAPY
    Publication number: 20120034693
    Abstract: A recombinant vector for delivering A3G genes into human cells comprising (i) a gene expression block including an A3G gene selected from a wild type A3G gene represented by SEQ ID NO: 1 and a mutant A3G gene and (ii) a group of elements from a modified lentiviral vector including lentiviral regions of packaging signal (?, psi), LTRs, RRE, and PBS; wherein said A3G gene is operably linked to the packaging signal (?, psi), LTRs, RRE, and PBS.
    Type: Application
    Filed: August 3, 2010
    Publication date: February 9, 2012
    Inventor: Hongzhan Xu
  • Recombinant vector and use in gene therapy
    Patent number: 7803582
    Abstract: A recombinant vector for delivering A3G genes into human cells comprising (i) a gene expression block including an A3G gene selected from a wild type A3G gene represented by SEQ ID NO: 1 and a mutant A3G gene and (ii) a group of elements from a modified lentiviral vector including lentiviral regions of packaging signal (?, psi), LTRs, RRE, and PBS; wherein said A3G gene is operably linked to the packaging signal (?, psi), LTRs, RRE, and PBS.
    Type: Grant
    Filed: March 17, 2007
    Date of Patent: September 28, 2010
    Inventor: Hongzhan Xu
  • RECOMBINANT VECTOR AND USE IN GENE THERAPY
    Publication number: 20080226675
    Abstract: A recombinant vector for delivering A3G genes into human cells comprising (i) a gene expression block including an A3G gene selected from a wild type A3G gene represented by SEQ ID NO: 1 and a mutant A3G gene and (ii) a group of elements from a modified lentiviral vector including lentiviral regions of packaging signal (?, psi), LTRs, RRE, and PBS; wherein said A3G gene is operably linked to the packaging signal (?, psi), LTRs, RRE, and PBS.
    Type: Application
    Filed: March 17, 2007
    Publication date: September 18, 2008
    Inventor: Hongzhan Xu
  • Mutant APOBEC3G molecules for inhibiting replication of HIV
    Publication number: 20080026982
    Abstract: Provided herein are novel APOBEC3G polypeptides having an amino acid substitution at position 129, e.g., P129D in which the polypeptide is capable of resisting proteosomal degradation induced by HIV-Vif. Also provided are isolated nucleic acids encoding the APOBEC3G polypeptides, recombinant vectors comprising the nucleic acids, recombinant host cells comprising the nucleic acid molecules encoding the polypeptides, pharmaceutical composition comprising the encoded protein, methods for resisting proteosomal degradation induced by HIV-Vif and thereby reducing or inhibiting HIV-1 and/or HIV-2 infection.
    Type: Application
    Filed: July 19, 2006
    Publication date: January 31, 2008
    Inventor: Hongzhan Xu