Abstract: An electrical stimulation device according to an embodiment includes: an elongated element having working channels; a plurality of electrical stimulators each including a longitudinal member extending along the longitudinal direction of the working channel, and a tip which is installed at the distal end of the longitudinal member and configured to apply electrical stimulation to a subject; and a control unit that independently controls the plurality of electrical stimulators to vary the range of electric stimulation applied to the subject.

Abstract: An electrical stimulation system according to an embodiment may comprise: a catheter having a long and thin tubular shape; an electrode disposed at one end of the catheter and inserted into a target portion; an electrical stimulator for generating electrical stimulation to be applied onto the target portion by the electrode; and a control part for controlling an electrical pulse of the electrical stimulator to change the electrical stimulation applied onto the target portion, wherein the electrode applies electrical stimulation in a state where a distal end of the electrode is enlarged and fixed to a target portion.

Abstract: The present invention relates to an endoscope suturing device and, more specifically, to an endoscopic suturing device capable of suturing a range of incisions by using an endoscope. According to the present invention, a wide range of incisions can be continuously sutured with high suturing power by using an endoscope, the suturing procedure time can be shortened, and a suturing method using a suture can minimize leftover foreign substances in the body, and thus can prevent side effects caused by the foreign substances. In addition, by using an endoscope, suturing with high-reliability is possible regardless of the range of suture areas, and thus the present invention can be used for simple suturing procedures and various internal surgeries such as gastrointestinal reduction surgery and NOTES, which uses a natural orifice.

Abstract: An electrical stimulation device according to an embodiment includes: an elongated element having working channels; a plurality of electrical stimulators each including a longitudinal member extending along the longitudinal direction of the working channel, and a tip which is installed at the distal end of the longitudinal member and configured to apply electrical stimulation to a subject; and a control unit that independently controls the plurality of electrical stimulators to vary the range of electric stimulation applied to the subject.

Abstract: A stimulator for a digestive organ includes a case, a substrate member disposed in the case, and an electrode member connected to the substrate member and extending to protrude outwardly from the case. The electrode member may have a shape of a wire and may be configured to provide an electrical stimulation in a state of being inserted and fixed at a predetermined location within a digestive organ.

Abstract: A stimulator for a digestive organ includes a case, a substrate member disposed in the case, and an electrode member connected to the substrate member and extending to protrude outwardly from the case. The electrode member may have a shape of a wire and may be configured to provide an electrical stimulation in a state of being inserted and fixed at a predetermined location within a digestive organ.

Abstract: The present invention relates to a therapeutic device which comprises: an endoscope channel; and an electrode that can be inserted into a human body through the endoscope channel, wherein the electrode destroys a target cell in the human body through voltage application, and the electrode includes a first optical fiber and a second optical fiber for detecting the degree of destruction of the target cell through impedance measurement. In addition, the present invention relates to a therapeutic device employing an endoscope-interworking electrode which comprises: an endoscope channel; and a catheter that can be inserted into a human body through the endoscope channel, wherein the catheter comprises a perforated portion provided on an end thereof, which is inserted into the human body, and a plurality of electrodes that can protrude from the end of the catheter through the perforated portion to penetrate a target cell.

Abstract: The present invention relates to a suturing bead, a suturing needle, a side suction cap and to an endoscopic organ suturing implement using same. More specifically, the present invention relates to an endoscopic organ suturing implement comprising a suturing bead which can be naturally rested lying against the organ wall during discharge, a suturing needle by means of which it is possible to control discharge of the suturing bead, and a side suction cap constituted in such a way as to be able to prevent damage to other organs during surgery.

Abstract: The present disclosure relates to a two-photon probe for in-vivo imaging, having high selectivity for copper(II) ion, and a method for quantitatively estimating copper(II) on (Cu2+) in vivo using the same. The two-photon probe according to the present disclosure can detect intracellular free copper(II) on for a long period of time with a penetration depth greater than 90 ?m in living cells and tissues without the problems of mistargeting and photobleaching and can quantitatively estimate copper(II) on concentration in vivo using the ratio of blue emission intensity at 400-450 nm and red emission intensity at 550-650 nm.

Abstract: The present disclosure relates to a two-photon fluorescent dye for imaging total sulfide in vivo and a method for quantitatively estimating total sulfide concentration in vivo using the same. The two-photon fluorescent dye, which includes a compound of [Chemical Formula 1], can detect hydrosulfide ion and image total sulfide and allows quantitative estimation of total sulfide concentration in vivo.

Abstract: The present invention relates to a suturing bead, a suturing needle, a side suction cap and to an endoscopic organ suturing implement using same. More specifically, the present invention relates to an endoscopic organ suturing implement comprising a suturing bead which can be naturally rested lying against the organ wall during discharge, a suturing needle by means of which it is possible to control discharge of the suturing bead, and a side suction cap constituted in such a way as to be able to prevent damage to other organs during surgery.

Abstract: A bead for stitching, a vacuum cap for suction-holding an internal organ, and an apparatus for stitching an internal organ using the vacuum cap are disclosed. The bead includes a through hole which is formed vertically through the bead so that a stitching fiber passes through the bead. At least one of both ends of the bead is inclined relative to a transverse direction of the bead. The bead is shaped to pass through a hole formed in a stitching needle. That apparatus includes an endoscope tube having a stitching needle which is movable in a longitudinal direction thereof and a suction tube for drawing air, and a vacuum cap having at an end thereof a fastening hole to which the endoscope tube is fastened. A suction hole is formed in the vacuum cap in a direction crossing the fastening hole.

Abstract: The present disclosure relates to a copper (I) ion-selective fluorescent probe, a method for preparing the same, and a method for diagnosing malignant disease and a diagnosis kit using the probe. The fluorescent probe according to the present disclosure is capable of detecting free copper (I) ions inside cells for a long time with high selectivity and sensitivity for copper (I) ion, with a penetration depth longer than 90 ?m in living cells and tissues and without the problems of mistargeting and photobleaching. Accordingly, since a biological sample can be imaged for a long period of time with high resolution without damage, presence of malignance disease in the target biological sample can be diagnosed faster, more accurately and more easily.

Abstract: A bead for stitching, a vacuum cap for suction-holding an internal organ, and an apparatus for stitching an internal organ using the vacuum cap are disclosed. The bead includes a through hole which is formed vertically through the bead so that a stitching fiber passes through the bead. At least one of both ends of the bead is inclined relative to a transverse direction of the bead. The bead is shaped to pass through a hole formed in a stitching needle. That apparatus includes an endoscope tube having a stitching needle which is movable in a longitudinal direction thereof and a suction tube for drawing air, and a vacuum cap having at an end thereof a fastening hole to which the endoscope tube is fastened. A suction hole is formed in the vacuum cap in a direction crossing the fastening hole.

Abstract: A bead for stitching, a vacuum cap for suction-holding an internal organ, and an apparatus for stitching an internal organ using the vacuum cap are disclosed. The bead includes a through hole which is formed vertically through the bead so that a stitching fiber passes through the bead. At least one of both ends of the bead is inclined relative to a transverse direction of the bead. The bead is shaped to pass through a hole formed in a stitching needle. That apparatus includes an endoscope tube having a stitching needle which is movable in a longitudinal direction thereof and a suction tube for drawing air, and a vacuum cap having at an end thereof a fastening hole to which the endoscope tube is fastened. A suction hole is formed in the vacuum cap in a direction crossing the fastening hole.