Abstract: One aspect of the disclosure relates to a cargo delivery system comprising an autophagy targeting ligand and a target-binding ligand. In one aspect of the disclosure, by comprising an autophagy targeting ligand, cargo, which is a target-binding ligand that specifically binds to a target, is delivered to the p62 protein and autophagy is activated, so that depending on the type of target-binding ligand used, a target to be degraded can be selectively and directly removed. Accordingly, the cargo delivery system according to an aspect of the disclosure may be used in pharmaceutical compositions or food compositions for preventing, alimerating, and treating various diseases.

Abstract: A non-transitory computer-readable medium, method and system, the system including processing circuitry. The processing circuitry is to generate a first matrix, perform an incident cycle optimization process using the first matrix to generate a modified first matrix, and perform an encoder gate optimization process using the modified first matrix to generate a further modified first matrix. Processing circuitry is then to generate a second matrix including the further modified first matrix as a submatrix of the second matrix, perform the incident cycle optimization process using the second matrix to generate a modified second matrix, and perform the encoder gate optimization process using the further modified first matrix and the modified second matrix to generate a further modified second matrix.

Abstract: A non-transitory computer-readable medium, method and system, the system including processing circuitry. The processing circuitry is to generate a first matrix, perform an incident cycle optimization process using the first matrix to generate a modified first matrix, and perform an encoder gate optimization process using the modified first matrix to generate a further modified first matrix. Processing circuitry is then to generate a second matrix including the further modified first matrix as a submatrix of the second matrix, perform the incident cycle optimization process using the second matrix to generate a modified second matrix, and perform the encoder gate optimization process using the further modified first matrix and the modified second matrix to generate a further modified second matrix.

Abstract: A compound represented by chemical formula 1, a salt, a stereoisomer, a solvent or a hydrate thereof, an antibacterial composition including the compound, and uses thereof are disclosed. The antibacterial composition is suitable for inhibiting bacterial infections, preventing, alleviating or treating bacterial infectious disease, and for preventing, alleviating or treating inflammation caused by a bacterial infection. The compound specifically binds to p62 protein so as to activate p62, thereby increasing the activity of autophagy, which is inhibited by a bacterial infection, and thus has antibacterial activity against various bacteria, can inhibit bacterial infectivity and has the excellent effect of enabling prevention, alleviation or treatment of bacterial infectious disease and inflammation caused by an infection.

Abstract: A non-transitory computer-readable medium and related method, including processing circuitry, which performs in-order error correction code construction. The processing circuitry receives a first plurality of matrices. The processing circuitry is to generate a second plurality of matrices based on at least one additive candidate matrix and each respective matrix of the first plurality of matrices. The processing circuitry then generates a third plurality of matrices based on at least one additive test matrix and each respective matrix of the second plurality of matrices. Each respective weight indicative of respective extensibility for each matrix of the second plurality of matrices is determined based on the third plurality of matrices. At least one matrix from the second plurality of matrices is then selected by processing circuitry based on the determined weights. The processing circuitry then generates an error correction code based on one of the at least one selected matrix.

Abstract: A non-transitory computer-readable medium and related method, including processing circuitry, which performs in-order error correction code construction. The processing circuitry receives a first plurality of matrices. The processing circuitry is to generate a second plurality of matrices based on at least one additive candidate matrix and each respective matrix of the first plurality of matrices. The processing circuitry then generates a third plurality of matrices based on at least one additive test matrix and each respective matrix of the second plurality of matrices. Each respective weight indicative of respective extensibility for each matrix of the second plurality of matrices is determined based on the third plurality of matrices. At least one matrix from the second plurality of matrices is then selected by processing circuitry based on the determined weights. The processing circuitry then generates an error correction code based on one of the at least one selected matrix.

Abstract: The present invention relates to a novel AUTOTAC chimeric compound in which a new p62 ligand and a target-binding ligand are connected by a linker, a stereoisomer, hydrate, solvate or prodrug thereof, and a pharmaceutical or food composition for the prevention or treatment of diseases by degrading the target protein including the same as an active ingredient. They can target specific proteins to adjust their concentrations, and can also deliver drugs and other small molecule compounds to lysosomes. The AUTOTAC chimeric compound according to the present invention can be usefully used as a pharmaceutical composition for the prevention, amelioration or treatment of various diseases by selectively eliminating specific proteins.

Abstract: The invention relates to a polishing slurry composition, and more specifically, relates to a polishing slurry composition that has excellent thermal stability, dispersion stability, stability over time, and polishing efficiency compared to conventional polishing slurry compositions, and can minimize scratches on the surface to be polished. The polishing slurry composition of the present invention has excellent thermal stability, dispersion stability, stability over time, and polishing efficiency, so it can be widely used in fields such as abrasives for semiconductor wafer processing, biomedical, pharmaceutical, cosmetics, and catalysts.

Abstract: The present invention relates to a novel p62 ligand compound, a stereoisomer, hydrate, solvate or prodrug thereof, and a pharmaceutical or food composition for preventing or treating proteinopathies comprising the same as an active ingredient. The p62 ligand compound according to the present invention can be usefully used as a pharmaceutical composition for the prevention, amelioration or treatment of various proteinopathies by activating autophagy in cells and thus selectively eliminating in vivo proteins, organelles and aggregates.

Abstract: A knee joint rehabilitation apparatus for a wheelchair includes a rehabilitation apparatus frame having a height corresponding to a length of each of legs of a patient sitting on the wheelchair; an upper leg support disposed at an upper end of the rehabilitation apparatus frame and supporting upper legs of the patient thereon while the patient is sitting on the wheelchair; a lower leg support pivotably connected to the upper leg support, wherein the lower legs of the patient are seated and supported on the lower leg support; and an exercise control unit disposed on the rehabilitation apparatus frame and configured to allow the lower leg support to pivot around a connection portion between the lower leg support and the upper leg support such that the patient performs rehabilitation exercise of the knee joint thereof while sitting on the wheelchair.

Abstract: Disclosed is an exoskeleton-type rehabilitation robot system, including: a body part provided on a chair in which a user sits and provided with a robot arm capable of moving left or right based on the user seated on the chair; a conversion part configured to convert a position of the robot arm with respect to the body part; a driving part configured to articulate the robot arm with respect to the body part; and a controller configured to detect a change in a position of the robot arm and control a left or right driving mode of the driving part according to the position of the robot arm. In accordance with such a configuration, the exoskeleton-type rehabilitation robot system of the present invention is provided integrally with a chair, thereby having excellent space utilization. In addition, the user's initial preparation for rehabilitation training is simple, which can improve efficiency.

Abstract: A sterilization system for a vehicle includes an outer housing configured to rotate about a first shaft and having an opening formed to face an interior space, an inner housing installed inside the outer housing, exposed to the interior space through the opening, configured to rotate about a second shaft, and having a light transmitting portion through which sterilizing light is transmitted, a light source embedded in the inner housing and configured to irradiate the sterilizing light toward the light transmitting portion, and a driver configured to rotate the outer housing and the inner housing to irradiate the sterilizing light to the interior space and to change an irradiation angle of the sterilizing light.

Abstract: A sterilizer for a vehicle includes: a module bracket fixed to an interior component of a vehicle; a slider slidably mounted on the module bracket; a module case connected to the slider; a sterilization module disposed within the module case and configured to radiate ultraviolet rays to an outside; and a motor fixed to the module bracket to drive the slider by a passenger's request.

Abstract: The present specification discloses a novel benzyloxy pyridine derivative compound represented by Chemical Formula 1, a salt thereof, a stereoisomer thereof, a hydrate thereof, or a solvate thereof, and novel uses thereof. The uses comprise the uses in the preparation of a composition for activating autophagy, a composition for activating p62 protein, a composition for inducing oligomerization of p62 protein, or a composition for ameliorating, preventing or treating a disease caused by misfolded protein.

Abstract: One aspect of the disclosure relates to a cargo delivery system comprising an autophagy targeting ligand and a target-binding ligand. In one aspect of the disclosure, by comprising an autophagy targeting ligand, cargo, which is a target-binding ligand that specifically binds to a target, is delivered to the p62 protein and autophagy is activated, so that depending on the type of target-binding ligand used, a target to be degraded can be selectively and directly removed. Accordingly, the cargo delivery system according to an aspect of the disclosure may be used in pharmaceutical compositions or food compositions for preventing, alimerating, and treating various diseases.

Abstract: The present specification relates to a compound as a UBR box domain ligand. The present specification provides a small molecule compound that binds to the UBR box domain. Further, the present specification provides a composition for inhibiting UBR box domain substrate binding, including a ligand compound that binds to a UBR box domain, a pharmaceutical composition for treating UBR-related disease, and a use thereof.

Abstract: The present specification relates to a compound as a UBR box domain ligand. The present specification provides a small molecule compound that binds to the UBR box domain. Further, the present specification provides a composition for inhibiting UBR box domain substrate binding, including a ligand compound that binds to a UBR box domain, a pharmaceutical composition for treating UBR-related disease, and a use thereof.

Abstract: Novel p62 ligand compounds, or a stereoisomer, a solvate, a hydrate, or a prodrug thereof are disclosed. The novel compounds, stereoisomer, solvate, hydrate, or prodrug activates selective autophagy in cells to selectively remove proteins, organelles, and coagulations in the body, and thus can be advantageously used as a pharmaceutical composition for preventing, ameliorating, or treating various proteinopathies. Compositions such as pharmaceutical composition or food compositions containing the novel p62 ligand compounds, stereoisomer, solvate, hydrate, or prodrug thereof as well as uses thereof are disclosed.

Abstract: A composition has effects for promoting endoplasmic reticulum (ER)-phagy, a composition for maintaining ER homeostasis or reducing ER stress, and a pharmaceutical composition for preventing and/or treating ER-stress-related diseases. The composition contains a p62 ligand compound as an active ingredient. The p62 ligand compound can modulate p62 to interact with a receptor associated with autophagic degradation of ER component, modulate oligomerization and/or aggregation of the receptor, modulate formation of autophagosomes, and the like. Thus, uses of p62 ligand compound in inducing ER-autophagy are provided.

Abstract: The present specification discloses a novel benzyloxy pyridine derivative compound represented by Chemical Formula 1, a salt thereof, a stereoisomer thereof, a hydrate thereof, or a solvate thereof, and novel uses thereof. The uses comprise the uses in the preparation of a composition for activating autophagy, a composition for activating p62 protein, a composition for inducing oligomerization of p62 protein, or a composition for ameliorating, preventing or treating a disease caused by misfolded protein.