Abstract: The present invention provides novel compounds that induce selective polo-like kinase 1 (PLK1) degradation. Specifically, the present invention provides a bifunctional compound in which a PLK1 binding moiety and an E3 ubiquitin ligase-binding moiety are linked by a chemical linker. The present invention provides the compound, a method for preparing the same, and the use thereof. The compounds may be effectively utilized for preventing or treating PLK1 related diseases.

Abstract: The present invention provides novel compounds that induce selective polo-like kinase 1 (PLK1) degradation. Specifically, the present invention provides a bifunctional compound in which a PLK1 binding moiety and an E3 ubiquitin ligase-binding moiety are linked by a chemical linker. The present invention provides the compound, a method for preparing the same, and the use thereof. The compounds may be effectively utilized for preventing or treating PLK1 related diseases.

Abstract: The present disclosure relates to an all solid-state battery cell and a method for manufacturing the same. The gaps between the electrode active material particles forming the electrode active material layer are filled with a mixture of a polymeric solid electrolyte with a conductive material, and an organic solid electrolyte membrane is interposed between the positive electrode and the negative electrode. The method comprises a solvent annealing process to improve the contact between the electrode active material particles and the conductive material and to improve the contact between the electrode active material layer and the organic solid electrolyte membrane, thereby providing an all solid-state battery cell with improved ion conductivity and capacity realization.

Abstract: A method for manufacturing a gel polymer electrolyte battery, the method comprising two steps of pressurization carried out before and after a formation step, is provided. The method provides a gel polymer electrolyte battery having a small gap between a separator and an electrode, high binding force, reduced thickness, improved shape stability and stiffness, and thus provides the gel polymer electrolyte battery having increased initial capacity, reduced initial resistance, and improved characteristics, such as cycle characteristics, high-temperature safety, overcharge safety and penetration safety.

Abstract: The present disclosure relates to a composition for a gel polymer electrolyte, including a lithium salt, a non-aqueous organic solvent, a polymerization initiator and a crosslinking agent, a gel polymer electrolyte formed by polymerizing the composition for a gel polymer electrolyte, and a lithium secondary battery including the same. According to an embodiment of the present disclosure, it is possible to inhibit the evaporation of a non-aqueous organic solvent by using a crosslinking agent, and to inhibit ignition propagation upon the ignition of a cell.

Abstract: The present invention pertains to: a polyol composition containing a polysaccharide alcohol, a polysaccharide alcohol-derived anhydrosugar alcohol, and an anhydrosugar alcohol polymer; and a polyurethane foam including same. More specifically, the present invention pertains to: a polyol composition containing a) a monoanhydrosugar alcohol, b) a dianhydrosugar alcohol, c) a polysaccharide alcohol, d) a polysaccharide alcohol-derived anhydrosugar alcohol, and e) at least one polymer of a) to d), wherein physical properties such as the number average molecular weight (Mn), polydispersity index (PDI), and average number of OH groups per molecule of the polyol composition satisfy certain levels, the polyol composition can contribute to the improvement of physical properties such as strength, elongation, and thermal insulation when used as a raw material for polyurethane, etc.

Abstract: The present invention relates to an alkylene-oxide-added polyol composition, a polyurethane using same, and a hot-melt adhesive comprising same, and, more specifically, to an alkylene oxide-added polyol composition, a polyurethane using same, and a hot-melt adhesive comprising same, the composition being prepared by performing, in a specific content ratio, an addition reaction between an alkylene oxide and an anhydrosugar alcohol composition comprising a) a monoanhydrosugar alcohol, b) a dianhydrosugar alcohol, c) a polysaccharide alcohol, d) an anhydrosugar alcohol derived from a polysaccharide alcohol, and e) a polymer of at least one of a) to d), and thus can increase the amount of bio components, improves adhesive strength, and enables a polyurethane to be prepared at a cost lower than that of when using petroleum polyols and other biopolyols.

Abstract: The present invention relates to a hydrophilic acrylic-modified polyurethane and a method for preparing same, and a water-based paint composition using same and a manufacturing method thereof and, more specifically, to a hydrophilic acrylic-modified polyurethane and a method for preparing same, and a water-based paint composition using same and a manufacturing method thereof, the hydrophilic acrylic-modified polyurethane comprising: a polymerization unit derived from an anhydrosugar alcohol-alkylene oxide adduct; a polymerization unit derived from polyisocyanate; and a polymerization unit derived from hydroxyalkyl (meth)acrylate, and capable of providing a water-based paint composition in which eco-friendliness, adhesiveness (adhesion), crack resistance and water resistance are all improved.

Abstract: The present invention provides novel compounds that induce selective polo-like kinase 1 (PLK1) degradation. Specifically, the present invention provides a bifunctional compound in which a PLK1 binding moiety and an E3 ubiquitin ligase-binding moiety are linked by a chemical linker. The present invention provides the compound, a method for preparing the same, and the use thereof. The compounds may be effectively utilized for preventing or treating PLK1 related diseases.

Abstract: The present disclosure relates to a method for manufacturing a secondary battery including a gel polymer electrolyte and a secondary battery obtained thereby. The method can inhibit thermal crosslinking of a gel polymer electrolyte during the wetting with an electrolyte, and facilitate thermal crosslinking after the wetting with an electrolyte is finished. In addition, the method can increase uniformity of thermal crosslinking by controlling the oxygen content in a cell.

Abstract: The present invention provides novel compounds that induce selective polo-like kinase 1 (PLK1) degradation. Specifically, the present invention provides a bifunctional compound in which a PLK1 binding moiety and an E3 ubiquitin ligase-binding moiety are linked by a chemical linker. The present invention provides the compound, a method for preparing the same, and the use thereof. The compounds may be effectively utilized for preventing or treating PLK1 related diseases.

Abstract: The present invention provides novel compounds that induce selective polo-like kinase 1 (PLK1) degradation. Specifically, the present invention provides a bifunctional compound in which a PLK1 binding moiety and an E3 ubiquitin ligase-binding moiety are linked by a chemical linker. The present invention provides the compound, a method for preparing the same, and the use thereof. The compounds may be effectively utilized for preventing or treating PLK1 related diseases.

Abstract: Proposed is a hybrid rocket engine using an electric motor-driven oxidizer pump, the hybrid rocket engine including: an oxidizer tank configured to store the oxidizer; an oxidizer pump configured to pressurize the oxidizer by being connected to the oxidizer tank through a first oxidizer supply line; a drive unit including an electric motor configured to drive the oxidizer pump and a battery configured to supply power to the electric motor; an auxiliary oxidizer line configured to guide the oxidizer from the oxidizer tank to the electric motor to cool the electric motor; an oxidizer recirculation line configured to recharge oxidizer vapor, generated through heat exchange between the electric motor and the oxidizer, to the oxidizer tank, thereby pressurizing an inner side of the oxidizer tank; and a combustion chamber configured to combust the oxidizer and fuel by being connected to the oxidizer pump through a second oxidizer supply line.

Abstract: The present invention relates to a composition for forming an environmentally friendly polyurethane foam, the composition having improved storage stability, air permeability, and anti-oxidation characteristics and to a method for manufacturing a polyurethane foam and, more specifically, to an isocyanate pre-polymer prepared by reaction of a polyisocyanate and a polyol component comprising a bio-polyol, to a composition for forming an environmentally friendly polyurethane foam, the composition having improved storage stability, air permeability, and anti-oxidative characteristics by comprising the pre-polymer as one component, to a method for manufacturing a polyurethane foam using the same, and to an environmentally friendly polyurethane foam manufactured thereby.

Abstract: A variable capacity swash plate type compressor includes: a cylinder block forming a plurality of cylinder bores; a first housing connected to the cylinder block and forming a crank chamber; a second housing; a drive shaft; a rotor mounted on the drive shaft to rotate with the drive shaft; a swash plate connected to the rotor by a hinge mechanism to rotate together with the rotor; and a plurality of pistons that are respectively disposed in the plurality of the cylinder bores and are connected the swash plate to undergo a linear reciprocating motion by a rotational motion of the swash plate. The hinge mechanism includes: a guide groove provided in the rotor; a connecting arm connected to the swash plate and having a cylindrical receiving space; and a cylindrical guide roller that is disposed in the receiving space in a state of being arranged in the guide groove.

Abstract: The present invention provides novel compounds that induce selective polo-like kinase 1 (PLK1) degradation. Specifically, the present invention provides a bifunctional compound in which a PLK1 binding moiety and an E3 ubiquitin ligase-binding moiety are linked by a chemical linker. The present invention provides the compound, a method for preparing the same, and the use thereof. The compounds may be effectively utilized for preventing or treating PLK1 related diseases.

Abstract: A negative electrode, a method for manufacturing the negative electrode, a secondary battery, and a method for manufacturing the secondary battery, wherein the negative electrode includes a negative electrode current collector, and a negative electrode active material layer. The negative electrode active material layer includes a first negative electrode active material layer on at least one surface of the negative electrode current collector and a second negative electrode active material layer on the first negative electrode active material layer. The first negative electrode active material layer includes ethylene carbonate.

Abstract: The present invention relates HMG-CoA reductase degradation inducing compounds. Specifically, the present invention relates a bifunctional compound in which a HMG-CoA reductase binding moiety and an E3 ubiquitin ligase-binding moiety are linked by a chemical linker. The present invention also relates a method for preparing the compounds, and a method for degradation of HMG-CoA reductase using the compounds, as well as use for prevention or treatment of HMG-CoA reductase related diseases using the compounds.

Abstract: Provided is a positive electrode for a secondary battery, which has a multi-layer structure including a first positive electrode active material layer and a second positive electrode active material layer, wherein the first positive electrode active material layer includes a first lithium composite transition metal oxide containing nickel, cobalt, and manganese, the second positive electrode active material layer includes a second lithium composite transition metal oxide containing nickel, cobalt, and manganese, the first lithium composite transition metal oxide and the second lithium composite transition metal oxide have mutually different nickel contents, wherein the positive electrode active material layer including a lithium composite transition metal oxide having a relatively high nickel content includes an electrolyte additive, and the positive electrode active material layer including a lithium composite transition metal oxide having a relatively low nickel content does not include an electrolyte addit

Abstract: Provided is a rocket for artificial rainfall using an ejection hygroscopic flare, the rocket including: a rocket body configured to descend with a parachute after flight by thrust, and having a hygroscopic flare discharge outlet; a communication module installed in the rocket body, and configured to transmit and receive a launch command and an ejection command with a ground station; an ejection hygroscopic flare installed in the rocket body and filled with cloud seeds and a burning material therein; and a hygroscopic flare ejection device configured to separate and eject the ejection hygroscopic flare from an inside of the rocket body to an outside thereof.