Patents by Inventor Hope T. Beier
Hope T. Beier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11872084Abstract: An acoustic imaging system responsive to an acoustic wave emitted from an object is disclosed. The system detects a deflection angle of an electromagnetic probe beam as it passes through a coupling element. The coupling element also couples the acoustic wave emitted from the object to an acoustic detector. The probe beam deflection angle is related to an angle of propagation of the acoustic wave through the coupling element. A filtering unit is configured to remove components of the signal from the acoustic detector that are outside of a range of angles, thereby improving the angular resolution of the acoustic detector. The acoustic wave may be generated by an acoustic source, such as an ultrasound transmitter, or an electromagnetic source such as a laser.Type: GrantFiled: August 22, 2022Date of Patent: January 16, 2024Assignee: United States of America as represented by the Secretary of the Air ForceInventors: Ronald A Barnes, Hope T Beier, Bennett L Ibey, Caleb Roth
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Publication number: 20230270415Abstract: An acoustic imaging system responsive to an acoustic wave emitted from an object is disclosed. The system detects a deflection angle of an electromagnetic probe beam as it passes through a coupling element. The coupling element also couples the acoustic wave emitted from the object to an acoustic detector. The probe beam deflection angle is related to an angle of propagation of the acoustic wave through the coupling element. A filtering unit is configured to remove components of the signal from the acoustic detector that are outside of a range of angles, thereby improving the angular resolution of the acoustic detector. The acoustic wave may be generated by an acoustic source, such as an ultrasound transmitter, or an electromagnetic source such as a laser.Type: ApplicationFiled: August 22, 2022Publication date: August 31, 2023Applicant: Government of the United States as represented by the Secretary of the Air ForceInventors: Ronald A. Barnes, Hope T. Beier, Bennett L. Ibey, Caleb Roth
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Patent number: 11439369Abstract: An acoustic imaging system responsive to an acoustic wave emitted from an object is disclosed. The system detects a deflection angle of an electromagnetic probe beam as it passes through a coupling element. The coupling element also couples the acoustic wave emitted from the object to an acoustic detector. The probe beam deflection angle is related to an angle of propagation of the acoustic wave through the coupling element. A filtering unit is configured to remove components of the signal from the acoustic detector that are outside of a range of angles, thereby improving the angular resolution of the acoustic detector. The acoustic wave may be generated by an acoustic source, such as an ultrasound transmitter, or an electromagnetic source such as a laser.Type: GrantFiled: October 26, 2017Date of Patent: September 13, 2022Assignee: United States of America as represented by the Secretary of the Air ForceInventors: Ronald A. Barnes, Hope T. Beier, Bennett L. Ibey, Caleb Roth
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Patent number: 10557793Abstract: Variations in a translucent medium are imaged by detecting deflections and/or polarization shifts in a probe beam transmitted through the translucent medium. Deflections and polarization shifts may be detected using a first polarizing filter positioned between a probe beam generator and the translucent medium to polarize the probe beam in a first direction, a beam splitter positioned to receive the probe beam after it has been transmitted through the medium, and a probe beam deflection detector that receives a first split beam and provides a deflection signal associated with refractive index variations in the medium. A second polarizing filter receives a second split beam and polarizes it in a second direction, perpendicular to the first direction. An intensity sensor receives the second split beam, after it has passed through the second polarizing filter, and provides an intensity signal associated with a polarization shift in the medium.Type: GrantFiled: August 8, 2018Date of Patent: February 11, 2020Assignee: United States of America as represented by the Secretary of the Air ForceInventors: Ronald A. Barnes, Hope T. Beier, Bennett L. Ibey, Caleb C Roth, Joel N Bixler, Christopher M Valdez
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Publication number: 20180321117Abstract: Systems and methods of fixing biological cells by laser irradiation. A method according to one embodiment of the present invention includes positioning a sample (of the cell or tissue) in a light pathway of a fixation source. The fixation source configured to emit electromagnetic radiation having a wavelength along the light pathway. The sample is exposed to the electromagnetic radiation for an exposure time.Type: ApplicationFiled: June 28, 2018Publication date: November 8, 2018Applicant: Government of the United States as Represented by the Secretary of the Air ForceInventors: Hope T. Beier, Bennett Ibey, Caleb C. Roth
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Patent number: 10054521Abstract: Systems and methods of fixing biological cells by laser irradiation. A method according to one embodiment of the present invention includes positioning a sample (of the cell or tissue) in a light pathway of a fixation source. The fixation source configured to emit electromagnetic radiation having a wavelength along the light pathway. The sample is exposed to the electromagnetic radiation for an exposure time.Type: GrantFiled: March 26, 2015Date of Patent: August 21, 2018Assignee: The United States of America as represented by the Secretary of the Air ForceInventors: Hope T Beier, Bennett Ibey, Caleb C. Roth
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Publication number: 20180224423Abstract: A method of inhibiting excitable cells. The method includes exposing the excitable cells to a pulse of infrared light having a wavelength ranging from 700 nm to about 3 ?m and having a radiant exposure at a surface of the excitable cells ranging from 1 ?J/cm2 to 1000 J/cm2.Type: ApplicationFiled: February 8, 2018Publication date: August 9, 2018Applicant: Government of the United States as Represented by the Secretary of the Air ForceInventors: Alexandra J. Walsh, Hope T. Beier, Bennett L. Ibey
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Publication number: 20160282237Abstract: Systems and methods of fixing biological cells by laser irradiation. A method according to one embodiment of the present invention includes positioning a sample (of the cell or tissue) in a light pathway of a fixation source. The fixation source configured to emit electromagnetic radiation having a wavelength along the light pathway. The sample is exposed to the electromagnetic radiation for an exposure time.Type: ApplicationFiled: March 26, 2015Publication date: September 29, 2016Applicant: Government of the United States as Represented by the Secretary of the Air ForceInventors: Hope T. Beier, Bennett Ibey, Caleb C. Roth
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Patent number: 8088595Abstract: This disclosure relates to a method of measuring a glucose concentration metric or a glucose metric in a patient by contacting an implantable glucose-sensing device with a test sample, which may be in the patient, under conditions that permit a sugar-binding molecule and a functionalized polymer or nano-particle ligand present throughout the matrix of a hydrogel to interact in a glucose-dependent manner to produce an optical signal resulting from quenching of a first fluorophore linked to the ligand or sugar-binding molecule and having a fluorescent emission spectrum quenched upon binding or release of glucose. Next the first fluorophore may be excited with light of a certain wavelength. Then at least one wavelength of light in the glucose-dependent optical signal from the fluorophore may be detected with a detector to produce a detected light signal, which may be processed to produce a glucose metric, such as a glucose concentration metric.Type: GrantFiled: March 5, 2010Date of Patent: January 3, 2012Assignee: The Texas A&M University SystemInventors: Bennett L. Ibey, Vamsi K. Yadavalli, Rebecca M. Rounds, Hope T. Beier, Gerard L. Cote, Michael V. Pishko
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Publication number: 20100222657Abstract: This disclosure relates to systems, devices, and methods of sensing an analyte. An implantable sensor may be contacted with a test sample under conditions that permit a binding protein and a ligand of the sensor to interact in an analyte-dependent manner to produce an analyte-dependent signal, and (b) detecting the analyte-dependent signal with a detector. A binding protein may reversibly bind an analyte and/or a ligand. A binding protein may have a higher binding affinity for an analyte than for a ligand. A binding protein and a ligand may each include a fluorophore, the absorption and/or emission properties of which may change in an analyte-dependent manner. A binding protein and/or a ligand may be bound to an active or inactive substrate. Some embodiments of systems, devices, and methods may be practiced in vitro, in situ, and/or in vivo. Systems and/or devices of the disclosure may be configured to be wearable.Type: ApplicationFiled: March 5, 2010Publication date: September 2, 2010Applicant: The Texas A&M University SystemInventors: Bennett L. Ibey, Vamsi K. Yadavalli, Rebecca M. Rounds, Hope T. Beier, Gerard L. Cote, Michael V. Pishko
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Patent number: 7704704Abstract: This disclosure relates to systems, devices, and methods of sensing an analyte. An implantable sensor may be contacted with a test sample under conditions that permit a binding protein and a ligand of the sensor to interact in an analyte-dependent manner to produce an analyte-dependent signal, and (b) detecting the analyte-dependent signal with a detector. A binding protein may reversibly bind an analyte and/or a ligand. A binding protein may have a higher binding affinity for an analyte than for a ligand. A binding protein and a ligand may each include a fluorophore, the absorption and/or emission properties of which may change in an analyte-dependent manner. A binding protein and/or a ligand may be bound to an active or inactive substrate. Some embodiments of systems, devices, and methods may be practiced in vitro, in situ, and/or in vivo. Systems and/or devices of the disclosure may be configured to be wearable.Type: GrantFiled: September 28, 2006Date of Patent: April 27, 2010Assignee: The Texas A&M University SystemInventors: Bennett L. Ibey, Vamsi K. Yadavalli, Rebecca M. Rounds, Hope T. Beier, Gerard L. Cote, Michael V. Pishko
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Publication number: 20090214392Abstract: A nano-fluidic trapping device and method of fabrication are disclosed. In one embodiment, a nano-fluidic trapping device for assembling a SERS-active cluster includes a substrate. The nano-fluidic trapping device further includes a SERS-active cluster compartment. The SERS-active cluster is formed in the SERS-active cluster compartment. In addition, the nano-fluidic trapping device includes a reservoir. The reservoir allows introduction of target molecules into the nano-fluidic trapping device. Moreover, the nano-fluidic trapping device includes a microchannel. The microchannel allows the target molecules to be introduced to the SERS-active cluster compartment from the reservoir. The nano-fluidic trapping device also includes a nanochannel. The SERS-active cluster compartment, the reservoir, the microchannel, and the nanochannel are disposed within the substrate.Type: ApplicationFiled: February 27, 2008Publication date: August 27, 2009Applicant: THE TEXAS A&M UNIVERSITY SYSTEMInventors: Jun Kameoka, Gerard L. Cote, Hope T. Beier, I-Hsien Chou, Melodie Benford, Miao Wang, Nan Jing