Patents by Inventor Horst Harr

Horst Harr has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Reductive amination of an amino acid or of an amino acid derivative with an .alpha.-keto acid or an .alpha.-keto acid derivative
    Patent number: 5387696
    Abstract: N-substituted .alpha.-amino acids and dipeptides are valuable intermediate products for the production of inhibitors of the angiotensin converting enzyme (ACE); representatives are e.g. enalapril and ramipril. These compounds are prepared by means of hydrogenolytic conversion of a primary amine with a ketone with the addition of an organic or inorganic base; among the inorganic bases, basic aluminum oxide is preferred. The use of chiral organic bases favors the production of a diastereomer.
    Type: Grant
    Filed: July 13, 1992
    Date of Patent: February 7, 1995
    Assignee: DeGussa Aktiengesellschaft
    Inventors: Matthias Kottenhahn, Karlheinz Drauz, Horst Harr