Patents by Inventor Horst Kleinkauf

Horst Kleinkauf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyclic depsipeptide synthetase and method for recombinant production
    Patent number: 7285404
    Abstract: The present invention provides an enzyme that synthesizes a cyclic depsipeptide, particularly the substance 1022, and a gene thereof. A cyclic depsipeptide synthetase according to the present invention comprises (a) an amino acid sequence of SEQ ID NO: 2 or (b) a modified amino acid sequence of the amino acid sequence of SEQ ID NO: 2 that have one or more modifications selected from a substitution, a deletion, an addition and an insertion and has cyclic depsipeptide synthetase activity. A cyclic depsipeptide synthetase gene according to the present invention comprises a nucleotide sequence encoding a cyclic depsipeptide synthetase. The present invention also provides a recombinant vector and a transformant for expressing the cyclic depsipeptide synthetase, and a mass production system for the cyclic depsipeptide. The present invention further provides a method for producing the cyclic depsipeptide synthetase.
    Type: Grant
    Filed: September 7, 2000
    Date of Patent: October 23, 2007
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Naoki Midoh, Kaoru Okakura, Koichi Miyamoto, Manabu Watanabe, Koji Yanai, Tetsuya Yasutake, Sato Aihara, Takafumi Futamura, Horst Kleinkauf, Takeshi Murakami
  • (R)-2-hydroxy-3-phenylpropionate (d-phenyllactate) dehydrogenase and gene encoding the same
    Patent number: 6916641
    Abstract: An objective of the present invention is to provide a D-phenyllactic acid dehydrogenase. Another objective of the present invention is to provide a gene which encodes the D-phenyllactic acid dehydrogenase. A D-phenyllactic acid dehydrogenase according to the present invention is a protein comprising an amino acid sequence of the amino acid sequence of SEQ ID NO: 2 or a modified amino acid sequence of the amino acid sequence of SEQ ID NO: 2 that has one or more modifications selected from a substitution, a deletion, an addition and an insertion and has D-phenyllactic acid dehydrogenase activity. A D-phenyllactic acid dehydrogenase gene according to the present invention comprises a nucleotide sequence which encodes the D-phenyllactic acid dehydrogenase, for example the nucleotide sequence of SEQ ID NO: 1.
    Type: Grant
    Filed: April 26, 2001
    Date of Patent: July 12, 2005
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Koichi Miyamoto, Naomi Sumida, Naoki Midoh, Takeshi Murakami, Rainer Zocher, Horst Kleinkauf
  • Novel (r)-2-hydroxy-3-phenylpropionate (d-phenyllactate) dehydrogenase and gene encoding the same
    Publication number: 20030186410
    Abstract: An objective of the present invention is to provide a D-phenyllactic acid dehydrogenase. Another objective of the present invention is to provide a gene which encodes the D-phenyllactic acid dehydrogenase. A D-phenyllactic acid dehydrogenase according to the present invention is a protein comprising an amino acid sequence of the amino acid sequence of SEQ ID NO: 2 or a modified amino acid sequence of the amino acid sequence of SEQ ID NO: 2 that has one or more modifications selected from a substitution, a deletion, an addition and an insertion and has D-phenyllactic acid dehydrogenase activity. A D-phenyllactic acid dehydrogenase gene according to the present invention comprises a nucleotide sequence which encodes the D-phenyllactic acid dehydrogenase, for example the nucleotide sequence of SEQ ID NO: 1.
    Type: Application
    Filed: November 7, 2002
    Publication date: October 2, 2003
    Inventors: Koichi Miyamoto, Naomi Sumida, Naoki Midoh, Takeshi Murakami, Rainer Zocher, Horst Kleinkauf
  • Process for the preparation of substituted aryl lactic acid containing cyclodepsipeptides with 24 ring atoms
    Patent number: 6033879
    Abstract: The present invention relates to a new process for the preparation of substituted aryllactic acid-containing cyclodepsipeptides having 24 ring atoms of the formula (I): ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 have the meaning given in the description,with the aid of fungal strains of the species Agonomycetales or enzymatic preparations isolated therefrom.
    Type: Grant
    Filed: June 4, 1998
    Date of Patent: March 7, 2000
    Assignee: Bayer Aktiengesellschaft
    Inventors: Peter Jeschke, Gerhard Bonse, Gerhard Thielking, Winfried Etzel, Achim Harder, Norbert Mencke, Horst Kleinkauf, Rainer Zocher, Katsuharu Iinuma, Kouichi Miyamoto
  • Lactic-acid-containing cyclic depsipeptides having 18 ring atoms as endoparasiticidal agents, and process for their preparation
    Patent number: 5945316
    Abstract: The present invention relates to a process for the preparation of lactic-acid-containing, optically active, cyclic depsipeptides having 18 ring atoms with the aid of fungal strains of the species Fusarium or enzymatic preparations isolated therefrom.
    Type: Grant
    Filed: March 20, 1997
    Date of Patent: August 31, 1999
    Assignee: Bayer Aktiengesellschaft
    Inventors: Peter Jeschke, Achim Harder, Norbert Mencke, Horst Kleinkauf, Rainer Zocher
  • Lactic-acid-containing cyclic depsipeptides having 18 ring atoms as endoparasiticidal agents, and process for their preparation
    Patent number: 5656464
    Abstract: The present invention relates to a process for the preparation of lactic-acid-containing, optically active, cyclic depsipeptides having 18 ring atoms with the aid of fungal strains of the species Fusarium or enzymatic preparations isolated therefrom.
    Type: Grant
    Filed: February 17, 1995
    Date of Patent: August 12, 1997
    Assignee: Bayer Aktiengesellschaft
    Inventors: Peter Jeschke, Achim Harder, Norbert Mencke, Horst Kleinkauf, Rainer Zocher