Abstract: The present invention provides N-methylated cyclic hexapeptides comprising RGD and at least one alanine residue. The present invention further provides prodrugs comprising the cyclic hexapeptides. Pharmaceutical compositions comprising said cyclic hexapeptides are also disclosed as well as methods of their production and use in treating integrin related conditions and diseases.

Abstract: A piston pump of the roller tappet type for high-pressure fuel delivery in fuel injection systems of internal combustion engines, particularly in common rail injection systems. A drive shaft that is supported in the pump housing and has a number of cam-like projections in the circumference direction. At least one tappet that is disposed in a cylinder chamber radially with regard to the drive shaft and in its radially inner end region has a rotatable roller which is supported so that it can roll in the circumference direction against the drive shaft in the region of its projections in order to reduce the wear in the region of the roller bearing. The pump is embodied so that a lubricant supply opening that leads from the circumference of the tappet and feeds into the radially inner tappet end region supporting the roller and at least during a part of the stroke, communicates with a lubricant supply line of the housing, which line feeds into the cylinder chamber.

Abstract: The invention relates to a quantity control valve for a fuel injection system, used in internal combustion engines, which includes a longitudinal slide that is movable in a valve housing between a first and a second control chamber and that allocates the fuel, flowing in from at least one low-pressure pump, to at least one high-pressure pump. For driving the longitudinal slide, the inflowing fuel is delivered into the first control chamber via a throttle or baffle valve, past the longitudinal slide. In the second control chamber, there is either a restoring spring that urges the longitudinal slide in the direction of its closing position, or the longitudinal slide there has an effective face-end surface area upstream of which a control line containing a throttle valve ends; this end face is smaller in surface area than the effective surface area of the face end in the first control chamber.

Abstract: A fuel injection system for internal combustion engines is proposed, in which with the aid of a high-pressure pump fuel is pumped at high pressure into a high-pressure fuel reservoir (6), from which electrically controlled fuel injection valves (9) are supplied. The pressure in the high-pressure fuel reservoir is maintained in such a way that a first pump element (16) pumps fuel into the high-pressure reservoir with a variable pumping quantity, and a second pump element (17) as needed pumps a constant high-pressure fuel quantity into the high-pressure reservoir. A simple, economical system is thus obtained for furnishing high fuel pressure for injection by the fuel injection system (FIG. 2).

Abstract: The invention relates to a quantity control valve for a fuel injection system, used in internal combustion engines, with a longitudinal slide that is movable in a valve housing between a restoring spring chamber and a control chamber and that allocates the fuel, flowing in from at least one low-pressure pump, to at least one high-pressure pump. For driving the longitudinal slide, the inflowing fuel in the control chamber is delivered past the longitudinal slide via a throttle or baffle valve. In the closing position, firstly, a cylindrical guide region of the longitudinal slide bounded on both sides by annular grooves blocks off an inlet bore. The guide region is wider than the diameter of the inlet bore. Secondly, it covers an outlet bore except for a partial intersection with the relieved annular groove shifted into the return in the opening direction of the longitudinal slide.

Abstract: A fuel injection system for internal combustion engines, having a high-pressure pump, whose pump work chamber can be made to communicate on the intake side with a fuel tank via a supply line and on the compression side with a common rail via a high-pressure line, from which common rail a plurality of injection lines lead away to the individual injection valves, and having one pressure valve each in the supply line and the high-pressure line, by way of which a return flow of fuel out of the pump work chamber into the supply line and out of the high-pressure line into the pump work chamber is prevented. The pressure valve of the supply line and the pressure valve of the high-pressure line are disposed in a common valve combination.

Abstract: A centrifugal speed governor, functioning as a minimum-maximum-speed governor, includes an adjusting member which is pivotable for adjusting the supply quantity, and the governor rod of the associated injection pump is adjustable via an intermediate lever by means of the adjusting member and a governor spring which is displaceable counter to the force of associated governor springs. The travel of the governor rod is limited in the direction of an increasing supply quantity by a governor rod stop including a starting spring. With the adjusting member resting on an end stop, the governor rod is pressed away from a basic test position (P) into its full-load position (V), and the differential travel (.DELTA.R) thereby resulting is absorbed by an accumulator in the governor linkage, preferably in the governor sleeve. The deflection stroke (A) of the accumulator is only slightly longer than that required to compensate for the differential travel (.DELTA.R).