Patents by Inventor Horst Koenig

Horst Koenig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4918072
    Abstract: A combination of a phenylacetonitrile and a pyridazinone derivative can be used for the treatment of thromboembolic disorders.
    Type: Grant
    Filed: February 20, 1987
    Date of Patent: April 17, 1990
    Assignee: BASF Aktiengesellschaft
    Inventor: Horst Koenig
  • Patent number: 4873246
    Abstract: Novel 6-(acylaminaryl)-3(2H)-pyridazinones of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, A and B have the meanings given in the description, and their preparation are described.The compounds have thrombocyte aggregation-inhibiting activity.
    Type: Grant
    Filed: October 8, 1986
    Date of Patent: October 10, 1989
    Assignee: BASF Aktiengesellschaft
    Inventors: Philip A. Rossy, Marco Thyes, Albrecht Franke, Horst Koenig, Hans D. Lehmann, Josef Gries, Ludwig Friedrich, Dieter Lenke
  • Patent number: 4772598
    Abstract: 2-aryl-3,4-diazabicyclo[4.n.0]-alk-2-en-5-ones of the formula ##STR1## where m, n, R, R.sup.1, R.sup.2 and R.sup.3 have the stated meanings, are used for the treatment of cardiac insufficiency.
    Type: Grant
    Filed: October 1, 1986
    Date of Patent: September 20, 1988
    Assignee: BASF Aktiengesellschaft
    Inventors: Karl-Heinz Geiss, Phillip A. Rossy, Marco Thyes, Horst Koenig, Hans D. Lehmann, Martin Traut, Josef Gries
  • Patent number: 4734405
    Abstract: A combination of acetylsalicylic acid and pyridazinone derivatives can be used for the treatment of thromboembolic disorders.
    Type: Grant
    Filed: October 9, 1986
    Date of Patent: March 29, 1988
    Assignee: BASF Aktiengesellschaft
    Inventor: Horst Koenig
  • Patent number: 4730042
    Abstract: Pyridine derivatives of the formula ##STR1## where R.sup.1 to R.sup.4 have the meanings stated in the description, and their preparation.The substances are useful for treating disorders.
    Type: Grant
    Filed: May 30, 1986
    Date of Patent: March 8, 1988
    Assignee: BASF Aktiengesellschaft
    Inventors: Hans-Guenther Hege, Gerhard Eisen, Horst Koenig, Gerda von Philipsborn
  • Patent number: 4663338
    Abstract: Viral diseases are treated by a method in which an effective amount of 1-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-yl)ethan-1-ol (formula I) ##STR1## is administered enterally, parenterally or topically to a patient suffering therefrom.
    Type: Grant
    Filed: March 13, 1986
    Date of Patent: May 5, 1987
    Assignee: BASF Aktiengesellschaft
    Inventors: Bernd Janssen, Horst Koenig, Peter Scharwaechter
  • Patent number: 4636504
    Abstract: Novel 6-(acylaminoaryl)-3(2H)-pyridazinones of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, A and B have the meanings given in the description, and their preparation are described and inhibiting thrombocyte aggregation and gastric secretion.The compounds are useful for treating disorders.
    Type: Grant
    Filed: January 17, 1984
    Date of Patent: January 13, 1987
    Assignee: BASF Aktiengesellschaft
    Inventors: Phillip A. Rossy, Marco Thyes, Albrecht Franke, Horst Koenig, Hans Dieter Lehmann, Josef Gries, Ludwig Friedrich, Dieter Lenke
  • Patent number: 4544562
    Abstract: 6-Aryl-4,5-dihydro-3(2H)-pyridazinones of the formula ##STR1## where R is hydrogen, R.sup.1 is hydrogen or C.sub.1 -C.sub.3 -alkyl, or R and R.sup.1 together are methylene, R.sup.2 and R.sup.3 are identical or different and are each hydrogen or C.sub.1 -C.sub.6 -alkyl, and A is hydroxyl, C.sub.1 -C.sub.6 -alkoxy, C.sub.2 -C.sub.7 -acyloxy, a C.sub.2 -C.sub.7 -carbamic acid ester group, C.sub.1 -C.sub.6 -alkylsulfonyloxy, C.sub.1 -C.sub.6 -alkylmercapto, carboxyl, C.sub.2 -C.sub.7 -alkoxycarbonyl or nitrile, and their preparation are described. The substances are suitable for treating disorders.
    Type: Grant
    Filed: March 11, 1983
    Date of Patent: October 1, 1985
    Assignee: BASF Aktiengesellschaft
    Inventors: Phillip A. Rossy, Marco Thyes, Albrecht Franke, Horst Koenig, Josef Gries, Hans D. Lehmann, Dieter Lenke
  • Patent number: 4474785
    Abstract: 2-Aryl-3,4-diazabicyclo[4.n.O]alk-2-en-5-ones of the formula I ##STR1## where m and n are identical or different and each is 1, 2 or 3, and R, R.sup.1 and R.sup.2 are identical or different and each is hydrogen or alkyl of 1 to 6 C atoms, said compounds are useful for treating high blood pressure and thrombo-embolic disorders.
    Type: Grant
    Filed: June 4, 1982
    Date of Patent: October 2, 1984
    Assignee: BASF Aktiengesellschaft
    Inventors: Phillip A. Rossy, Marco Thyes, Albrecht Franke, Horst Koenig, Josef Gries, Hans D. Lehmann, Dieter Lenke
  • Patent number: 4415571
    Abstract: Novel 6-phenyl-4,5-dihydro-3(2H)-pyridazinones which are substituted in the p-position of the phenyl ring by a carbamate or thiocarbamate group, processes for their preparation, pharmaceutical formulations containing these compounds, and their use as drugs in thrombo-embolic disorders, and as anti-hypertensives.
    Type: Grant
    Filed: June 9, 1981
    Date of Patent: November 15, 1983
    Assignee: BASF Aktiengesellschaft
    Inventors: Marco Thyes, Albrecht Franke, Horst Koenig, Dieter Lenke, Hans D. Lehmann, Josef Gries
  • Patent number: 4410529
    Abstract: Novel 6-(p-acylaminophenyl)-4,5-dihydro-3(2H)-pyridazinones, whose acyl radical is derived from a cycloalkylcarboxylic acid, processes for their preparation, pharmaceutical formulations containing these compounds, and their use as drugs in thrombo-embolic disorders and as anti-hypertensives.
    Type: Grant
    Filed: June 12, 1981
    Date of Patent: October 18, 1983
    Assignee: BASF Aktiengesellschaft
    Inventors: Marco Thyes, Horst Koenig, Dieter Lenke, Hans D. Lehmann, Josef Gries
  • Patent number: 4376771
    Abstract: 6-(p-Acylaminophenyl)-4,5-dihydropyridaz-3-ones of the formula I ##STR1## where R.sup.1 is hydrogen or alkyl of 1 to 3 carbon atoms and R.sup.2, if R.sup.1 is hydrogen, is halogen-substituted alkyl of 3 to 6 carbon atoms or .beta.-haloethyl or, if R.sup.1 is alkyl of 1 to 3 carbon atoms, is halogen-substituted alkyl of 1 to 6 carbon atoms, their manufacture, and therapeutic agents which contain, as the active ingredient, a compound of the formula I, where R.sup.2 may also be halomethyl or .alpha.-haloethyl if R.sup.1 is hydrogen. These compounds may be used as anti-hypertensive agents and for the prophylaxis and therapy of thromboembolic disorders.
    Type: Grant
    Filed: January 14, 1981
    Date of Patent: March 15, 1983
    Assignee: BASF Aktiengesellschaft
    Inventors: Rolf Lebkuecher, Marco Thyes, Horst Koenig, Hans D. Lehmann, Josef Gries, Dieter Lenke, Johannes Kunze
  • Patent number: 4280008
    Abstract: Chirally substituted 2-imidazolin-5-ones and their use as intermediates for the preparation of optically active aminoacids, especially of optically active .alpha.-substituted aminoacids.
    Type: Grant
    Filed: December 16, 1977
    Date of Patent: July 21, 1981
    Assignee: BASF Aktiengesellschaft
    Inventors: Ulrich Schoellkopf, Hans-Heinrich Hausberg, Walter Boell, Hans-Joachim May, Horst Koenig
  • Patent number: 4269990
    Abstract: The invention relates to 1-acyl-2-imidazolines, processes for their manufacture, and their use as intermediates.
    Type: Grant
    Filed: December 5, 1979
    Date of Patent: May 26, 1981
    Assignee: BASF Aktiengesellschaft
    Inventors: Hans-Joachim May, Horst Koenig
  • Patent number: 4267187
    Abstract: Alkylaminopropanol derivatives of 2-(o-hydroxyphenyl)-pyrrole of the formula (I) ##STR1## where R is hydrogen or is alkyl of 1 to 8 carbon atoms which is unsubstituted or substituted by hydroxyl, alkoxy of 1 to 3 carbons atoms or cycloalkyl of 3 to 8 carbon atoms in the ring, or is alkenyl or alkynyl of 2 to 8 carbon atoms or is cycloalkyl or cycloalkenyl of 3 to 8 carbon atoms in the ring, the cycloalkyl rings being unsubstituted or monosubstituted or disubstituted by alkyl or 1 to 3 carbon atoms, and their physiologically acceptable acid addition salts, processes for their preparation, and pharmaceutical formulations which contain the said compounds and may be used in the treatment of cardiac and circulatory disorders.
    Type: Grant
    Filed: August 8, 1979
    Date of Patent: May 12, 1981
    Assignee: BASF Aktiengesellschaft
    Inventors: Fritz-Frieder Frickel, Albrecht Franke, Horst Koenig, Hans-Dieter Lenke, Josef Gries
  • Patent number: 4240964
    Abstract: 2-(o-Hydroxyphenyl)-pyrrole and a process for its preparation, wherein o-benzyloxybenzoic acid allylamide is reacted with phosgene in an inert solvent, the resulting imide-chloride is cyclized in the presence of a strong sterically hindered base and the benzyl protective group is then removed by hydrogenolysis.2-(o-Hydroxyphenyl)-pyrrole is a valuable intermediate for the synthesis of drugs. In particular, alkylamino-hydroxypropyl ethers thereof can, because of their .beta.-sympatholytic actions, be used for the treatment of coronary cardiac diseases, cardiac arrhythmias and hypertonia.
    Type: Grant
    Filed: August 8, 1979
    Date of Patent: December 23, 1980
    Assignee: BASF Aktiengesellschaft
    Inventors: Horst Koenig, Albrecht Franke, Fritz-Frieder Frickel, Wolfgang Steglich, Norbert Engel
  • Patent number: 4168379
    Abstract: New pyridin-3-ols and their N-oxides and acid addition salts, which are useful as intermediates, especially for the preparation of pharmacologically active compounds, and their preparation.
    Type: Grant
    Filed: March 10, 1978
    Date of Patent: September 18, 1979
    Assignee: BASF Aktiengesellschaft
    Inventors: Walter Boell, Horst Koenig
  • Patent number: 4156765
    Abstract: New polymers with K values of from 20 to 140, in which the side chains contain optically active 1,6,6-trimethylnorpinanyl-2-methyl or 3-pinanyl-methyl groups, so that the polymers are also optically active. The polymers are used for the production of coatings and adhesives, as optical modifiers for films, and for finishing paper and textiles.
    Type: Grant
    Filed: February 27, 1978
    Date of Patent: May 29, 1979
    Assignee: BASF Aktiengesellschaft
    Inventors: Heinz Pohlemann, Horst Koenig, Hardo Siegel, Herbert Naarmann
  • Patent number: 4146724
    Abstract: The new isopropyl 4-methylimidazole-5-carboxylate and a new process for its manufacture by reacting isopropyl chloroacetoacetate with formamide and water in the presence of formic acid. Isopropyl 4-methylimidazole-5-carboxylate, manufactured by the process of the invention, is a starting material for the manufacture of dyes, pharmaceuticals and pesticides.
    Type: Grant
    Filed: September 23, 1977
    Date of Patent: March 27, 1979
    Assignee: BASF Aktiengesellschaft
    Inventors: Albrecht Friederang, Horst Koenig
  • Patent number: RE33476
    Abstract: Novel 6-(acylaminoaryl)-3(2H)-pyridazinones of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, A and B have the meanings given in the description, and their preparation are described.[.and inhibiting thrombocyte aggregation and gastric secretion.]..The compounds are useful for treating disorders .Iadd.and inhibiting thrombocyte aggregation and gastric secretion.Iaddend..
    Type: Grant
    Filed: May 2, 1988
    Date of Patent: December 4, 1990
    Assignee: BASF Akteingesellschaft
    Inventors: Phillip A. Rossy, Marco Thyes, Albrecht Franke, Horst Koenig, Hans D. Lehmann, Josef Gries, Ludwig Friedrich, Dieter Lenke