Abstract: The present invention relates to a multi-functional pharmaceutical package surface and a method of preparing a multi-functional pharmaceutical package surface. In particular, the present invention relates to a pharmaceutical package having a protein deterrent and lubricious surface and methods of preparing said surface by applying coatings directly to the pharmaceutical package that (a) reduce the adsorption of proteins onto pharmaceutical packaging while not affecting the activity of the protein solution and (b) provide a lubricious surface. The pharmaceutical package surface may also contain a barrier coating. Coatings can be deposited on a variety of pharmaceutical packaging materials and configurations by various methods.

Abstract: A method of preparing a macromolecule deterrent surface on a pharmaceutical package. In particular, the present invention relates to a method of preparing a protein deterrent surface on a pharmaceutical package by applying a coating or coatings directly to the pharmaceutical package that reduces the adsorption of proteins onto pharmaceutical packaging while not affecting the activity of the protein solution contained.

Abstract: A multiplexed assay method capable of measuring the interaction of one or more protein, polypeptide or peptide solutions with one or more substrate surfaces comprises contacting each of the wells of a multiwell substrate with the same or different protein solution, the surfaces of said wells being the same as that of said substrate or being substrate surface treated and/or coated to provide test surfaces, and determining the level of protein adsorption in each of said wells.

Abstract: A method of preparing a macromolecule deterrent surface on a pharmaceutical package. In particular, the present invention relates to a method of preparing a protein deterrent surface on a pharmaceutical package by applying a coating or coatings directly to the pharmaceutical package that reduces the adsorption of proteins onto pharmaceutical packaging while not affecting the activity of the protein solution contained.

Abstract: The present invention relates to a multi-functional pharmaceutical package surface and a method of preparing a multi-functional pharmaceutical package surface. In particular, the present invention relates to a pharmaceutical package having a protein deterrent and lubricious surface and methods of preparing said surface by applying coatings directly to the pharmaceutical package that (a) reduce the adsorption of proteins onto pharmaceutical packaging while not affecting the activity of the protein solution and (b) provide a lubricious surface. The pharmaceutical package surface may also contain a barrier coating. Coatings can be deposited on a variety of pharmaceutical packaging materials and configurations by various methods.

Abstract: The syringe is formed according to DIN ISO 11040 and has a syringe barrel (1) with a syringe head (1a) formed on one end and a grip plate (4) formed at the other open end. An elastomeric piston stopper (6) is insertable in this open end, which is movable back and forth and which has a cruciform-cross-sectioned piston rod (7) screwed into it. A stop element, which reduces the interior diameter of the syringe barrel, is provided at the open end of the syringe barrel to perform a back-stop function, i.e. to prevent unintended withdrawal of the piston stopper. For this purpose a plastic part (2) connected to the grip plate (4) is provided with snap catches (3), which snap onto the inner side of the syringe barrel (1). These snap-catches (3) prevent the piston rod (7) from being rotated out of the piston stopper and the piston stopper (6) from being withdrawn from the syringe barrel. At the same time the finger support is enlarged.

Abstract: A method of preparing a macromolecule deterrent surface on a pharmaceutical package. In particular, the present invention relates to a method of preparing a protein deterrent surface on a pharmaceutical package by applying a coating or coatings directly to the pharmaceutical package that reduces the adsorption of proteins onto pharmaceutical packaging while not affecting the activity of the protein solution contained.

Abstract: The syringe is formed according to DIN ISO 11040 and has a syringe barrel (1) with a syringe head (1a) formed on one end and a grip plate (4) formed at the other open end. An elastomeric piston stopper (6) is insertable in this open end, which is movable back and forth and which has a cruciform-cross-sectioned piston rod (7) screwed into it. A stop element, which reduces the interior diameter of the syringe barrel, is provided at the open end of the syringe barrel to perform a back-stop function, i.e. to prevent unintended withdrawal of the piston stopper. For this purpose a plastic part (2) connected to the grip plate (4) is provided with snap catches (3), which snap onto the inner side of the syringe barrel (1). These snap-catches (3) prevent the piston rod (7) from being rotated out of the piston stopper and the piston stopper (6) from being withdrawn from the syringe barrel. At the same time the finger support is enlarged.

Abstract: The syringe, especially a pre-filled one-time-use syringe, has a syringe body, which includes a cylindrical supply chamber for a liquid to be injected and a piston with a piston rod axially connected to it. A finger support is provided at one end of the syringe body and an end portion for holding a hollow needle is provided at the other end of the syringe body. The hollow needle is clamped in a needle channel provided in the end portion. A method of making a syringe body is described, in which the cylindrical storage chamber is made in one piece with a threaded connector by an injection molding process, the end portion provided with the hollow needle clamped in it is made in another injection molding process and then after making the end portion and the cylindrical storage chamber the cylindrical storage chamber is connected with the end portion.

Abstract: New hydrated niobium oxide and hydrated tantalum oxide catalysts containing pores having diameters in the range from 0.4 to 10,000 nm are characterized in that the volume of the pores of the catalyst having a diameter of from 100 to 1000 nm is at least 30% of the total pore volume of the catalyst. The catalysts can be prepared by mixing hydrated niobium oxide or hydrated tantalum oxide with an inert solid and converting this mixture into a solid pellet form, with the pressure in the apparatus for preparing catalysts in pellet form being set in such a way that the volume of the pores of the catalyst having a diameter of from 100 to 1000 nm is at least 30% of the total pore volume of the catalyst. Such catalysts are particularly suitable for preparing N-alkylanilines from anilines and alkanols.

Abstract: The isomerization of humulone or a humulone-containing material is carried out by isomerization at elevated temperature and a pH below 9 in a liquid medium containing at least one salt of a bi-valent metal or of cerium.

Abstract: Thymol can be prepared on a continuous basis by reacting m-cresol with propylene and/or compounds which eliminate propylene, over aluminum oxide catalysts in the presence of a nitrogen base. The aluminum oxide catalyst is an active or activated hydrated aluminum oxide having a particle size between 0.5 and 20 mm, a BET surface area of at least 200 m.sup.2 /g, a porosity equal to or greater than 0.5 mm/g, a boehmite content of 5 to 40 percent by weight, and an X-ray spectrum which shows the reflections of .gamma.-alumina wherein the content of microcrystalline constituents is less than 50 percent by weight.

Abstract: A hydrogenation catalyst containing cobalt, manganese and copper in the form of their oxides and alkali metal oxide and silicon dioxide. A weight ratio of cobalt to maganese is 25:1 to 1:1, and the copper content is 0.01 to 2% by weight based on a total weight of the catalyst. The catalyst is prepared by adding an excess of an aqueous solution of a hydroxide, bicarbonate or carbonate of an alkali metal to an aqueous solution of water-soluble cobalt salts, manganese-(II) salts and copper salts to form a precipitate. Thereafter an aqueous solution of an alkali metal silicate or SiO.sub.2 sol is added to the precipitate which is filtered off and washed with water to remove excess alkali metal hydroxide, bicarbonate or carbonate. The precipitate is then dried and calcined to form the catalyst.

Abstract: The isomerization of humulone or a humulone-containing material is carried out by isomerization at elevated temperatures and a pH below 9 in a liquid medium containing at least one salt of a bi-valent metal or of cerium.

Abstract: Hydroxydiphenyl is prepared by dehydrogenating a starting material comprising completely and/or partly hydrogenated hydroxydiphenyl in a gaseous phase in the presence of a dehydrogenation catalyst and a compound having the formula ##SPC1##WhereinR.sup.1, r.sup.2 and R.sup.3, which may be the same or different, each represents a linear or optionally branched alkyl radical having up to 6 carbon atoms, in addition to which R.sup.3 can also represent a hydrogen atom,Is added as a stabilizer to the starting material before it comes into contact for the first time with and and/or other oxygen-containing gases.