Patents by Inventor Horst Pauling
Horst Pauling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7153984Abstract: A process for the manufacture of (all-rac)-?-tocopherol by the acid-catalyzed reaction of trimethylhydroquinone with isophytol or phytol is characterized by carrying out the reaction in the presence of methane trisulphonate as the catalyst in an organic solvent. The product of the process is the most active and industrially most important member of the vitamin E group.Type: GrantFiled: September 30, 2003Date of Patent: December 26, 2006Assignee: DSM IP Assets B.V.Inventors: Werner Bonrath, Alois Haas, Simone Hoppmann, Thomas Netscher, Horst Pauling
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Publication number: 20060020139Abstract: A process for the manufacture of (all-rac)-?-tocopherol by the acid-catalyzed reaction of trimethylhydroquinone with isophytol or phytol is characterized by carrying out the reaction in the presence of methane trisulphonate as the catalyst in an organic solvent. The product of the process is the most active and industrially most important member of the vitamin E group.Type: ApplicationFiled: September 30, 2003Publication date: January 26, 2006Applicant: DSM IP Assets B.V.Inventors: Werner Bonrath, Alois Haas, Simone Hoppmann, Thomas Netscher, Horst Pauling
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Patent number: 6482961Abstract: The present invention is a method of making (all-rac)-&agr;-tocopherol in a reaction having the following steps: a) reacting trimethylhydroquinone and a phytol selected from the group consisting of isophytol and phytol in the presence of a bis(perfluorinated hydrocarbyl sulphonyl)imide catalyst or a metal salt thereof of formula I: [(R1SO2)2N]xR2 (I) wherein each R1, independently, signifies a perfluoroalkyl group CnF2n+1 or a pentafluorophenyl, or both symbols R1 together signify a poly-difluoromethylene group—(CF2)m—, with the proviso that both symbols R1 cannot simultaneously signify trifluoromethyl, R2 signifies a proton or a cationic form of a metal selected from the group consisting of boron, magnesium, aluminum, silicon, scandium, titanium, vanadium, manganese, iron, cobalt, nickel, copper, zinc, yttrium, zirconium, rhodium, palladium, silver, tin, lanthanum, cerium, praseodymium, neodymium, europium, dysprosium, thulium, ytterbium, hafnium, platinum, anType: GrantFiled: August 16, 2001Date of Patent: November 19, 2002Assignee: Roche Vitamins Inc.Inventors: Werner Bonrath, Alois Haas, Eike Hoppmann, Horst Pauling
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Publication number: 20020072619Abstract: The present invention is a method of making (all-rac)-&agr;-tocopherol in a reaction having the following steps:Type: ApplicationFiled: August 16, 2001Publication date: June 13, 2002Inventors: Werner Bonrath, Alois Haas, Eike Hoppmann, Horst Pauling
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Patent number: 6369242Abstract: A method of making (all-rac.)-&agr;-tocopherol by the acid-catalyzed condensation of trimethylhydroquinone with isophytol or phytol wherein the condensation is carried out in the presence of a tris(perfluoroalkanesulphonyl or pentafluorobenzenesulphonyl)methane or a metal salt thereof as the catalyst in an organic solvent. In addition to the metal salt, a Bronsted acid, e.g. sulfuric acid, phosphoric acid or p-toluenesulphonic acid, may be used as a co-catalyst. The product of the method of making is the most active member of the vitamin E group.Type: GrantFiled: March 8, 2001Date of Patent: April 9, 2002Assignee: Roche Vitamins Inc.Inventors: Werner Bonrath, Alois Haas, Eike Hoppmann, Thomas Netscher, Horst Pauling
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Publication number: 20010027255Abstract: A method of making (all-rac.)-&agr;-tocopherol by the acid-catalyzed condensation of trimethylhydroquinone with isophytol or phytol wherein the condensation is carried out in the presence of a tris(perfluoroalkanesulphonyl or pentafluorobenzenesulphonyl)methane or a metal salt thereof as the catalyst in an organic solvent. In addition to the metal salt, a Bronsted acid, e.g. sulfuric acid, phosphoric acid or p-toluenesulphonic acid, may be used as a co-catalyst. The product of the method of making is the most active member of the vitamin E group.Type: ApplicationFiled: March 8, 2001Publication date: October 4, 2001Applicant: F. Hoffmann-La Roche AGInventors: Werner Bonrath, Alois Haas, Eike Hoppmann, Thomas Netscher, Horst Pauling
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Patent number: 5910594Abstract: A process for the manufacture of a 5-cyano-4-lower alkyl-oxazole by the dehydration of a 5-carbamoyl-4-lower alkyl-oxazole is disclosed. The reaction is carried out by dehydrating the oxazole with silicon tetrachloride in the presence of an amine in an aprotic organic solvent. 5-Carbamoyl-4-methyl-oxazole may be dehydrated by the process in accordance with the invention to obtain 5-cyano-4-methyl-oxazole, which is a valuable intermediate in the synthesis of pyridoxine.Type: GrantFiled: January 20, 1998Date of Patent: June 8, 1999Assignee: Roche Vitamins Inc.Inventors: Klaus Behringer, Werner Bonrath, Horst Pauling
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Patent number: 5908939Abstract: A process for the manufacture of d,1-.alpha.-tocopherol by the catalyzed condensation of trimethylhydroquinone with isophytol comprises carrying out the condensation in the presence of bis-(trifluoromethylsulphonyl)amine ?HN(SO.sub.2 CF.sub.3).sub.2 ! or a metal salt thereof of the formula Met ?N(SO.sub.2 CF.sub.3).sub.2 !.sub.n (I), wherein Met signifies a metal atom selected from the group of lithium, boron, magnesium, aluminium, silicon, scandium, titanium, vanadium, manganese, iron, cobalt, nickel, copper, zinc, yttrium, zirconium, rhodium, palladium, silver, tin, lanthanum, cerium, neodymium, praseodymium, europium, dysprosium, ytterbium, hafnium, platinum and gold and n signifies the corresponding valency (1, 2, 3, or 4) of the metal atom Met, as the catalyst or of a combination of a metal salt of formula I and a strong Bronsted acid as the catalyst system in an organic solvent. The product of the process is the most active member of the vitamin E group.Type: GrantFiled: October 16, 1997Date of Patent: June 1, 1999Assignee: Roche Vitamins Inc.Inventors: Marcel Baak, Werner Bonrath, Horst Pauling
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Patent number: 5817827Abstract: The present invention relates to a process for the dehydration of amides to nitrites which comprises carrying out the dehydration in the presence of an adduct of sulphur trioxide and an amine as the dehydrating reagent in a basic reaction mixture. Thereby, for example, aliphatic, aromatic and heteroaromatic amides are dehydrated to the corresponding nitrites, such as 5-carbamoyl-4-methyl-oxazole to 5-cyano-4-methyl-oxazole, a valuable intermediate in the synthesis of pyridoxine.Type: GrantFiled: October 22, 1996Date of Patent: October 6, 1998Assignee: Hoffmann-La Roche Inc.Inventors: Werner Bonrath, Horst Pauling
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Patent number: 5502212Abstract: A process for the manufacture of 5-cyano-4-lower alkyl-oxazoles is described in which a 5-carbamoyl-4-lower alkyl-oxazole is dehydrated in an organic solvent under mild conditions with cyanuric chloride and an N,N-disubstituted-formamide.Type: GrantFiled: February 16, 1994Date of Patent: March 26, 1996Assignee: Hoffmann-La Roche Inc.Inventors: Werner Bonrath, Reinhard Karge, Horst Pauling
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Patent number: 5336683Abstract: The invention is concerned with novel antioxidants, namely the [R] and, respectively, [S] compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 together represent the --S(O)-- group and R.sup.3 and R.sup.4 represent hydrogen, or R.sup.3 and R.sup.4 together represent the --S(O)-- group and R.sup.1 and R.sup.2 represent hydrogen.Type: GrantFiled: January 13, 1993Date of Patent: August 9, 1994Assignee: Hoffmann-La Roche Inc.Inventors: Horst Pauling, Christof Wehrli
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Patent number: 5210220Abstract: The invention is concerned with a process for the manufacture of ascorbyl phosphates, namely of phosphates of the formula ##STR1## wherein M.sup.k.sym. denotes a cation, k.sup..sym. denotes the valency and m denotes the equivalents, with the proviso that the product from k.m=3, by phsophorylating ascorbic acid.k is 1 to 3, especially 1 or 2.The process comprises using pre-formed sodium (or potassium) dichlorophosphate as the phosphorylating reagent, adding ascorbic acid to this pre-formed phosphorylating reagent in aqueous solution, especially at pH values between about 11.0 and about 13.0, in the presence of a water-soluble trialkylamine as the catalyst and at temperatures between about +10.degree. C. and about -8.degree. C., especially at temperatures below 0.degree. C., and, if desired, trans-salting the I which is obtained as the sodium (or potassium) salt and/or, if desired, purifying via an amine salt.Type: GrantFiled: October 25, 1991Date of Patent: May 11, 1993Assignee: Hoffmann-La Roche Inc.Inventors: Horst Pauling, Christof Wehrli
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Patent number: 4997958Abstract: A process for the manufacture of 6-aliphatic C.sub.2-20 -carboxylic acid esters of ascorbic acid by esterifying the ascorbic acid with an aliphatic C.sub.2-20 -carboxylic acid halide in the presence of a N,N-dialkyl-alkanecarboxylic acid amide, of a cyclic amide of the 1-methyl-2-pyrrolidone type, of a tetraalkylcarbamide such as tetramethylurea, of a cyclic carbamide of the 1,3-dimethyl-2-imidazolidinone type or of a phosphoric acid triamide of the hexamethylphosphoric acid triamide type. The 6-ascorbyl linolate which can be manufactured in this manner is novel and is likewise an object of the present invention. The thus-manufacturable 6-aliphatic C.sub.2-20 -carboxylic acid esters of ascorbic acid are important alternative application forms of L-ascorbic acid (vitamin C).Type: GrantFiled: March 10, 1989Date of Patent: March 5, 1991Assignee: Hoffmann-La Roche Inc.Inventors: Horst Pauling, Christof Wehrli
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Patent number: 4881993Abstract: The carbonyl compounds 5,6-carbonyl-ascorbic acid and 5,6-carbonyl-erythorbic acid been found useful for the preparation of explosive and propellant materials by admixing them with nitrate-containing oxidation agents and optionally further ingredients.Type: GrantFiled: June 29, 1989Date of Patent: November 21, 1989Assignee: Hoffman-LA Roche Inc.Inventors: Claude Furbringer, Horst Pauling
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Patent number: 4841070Abstract: The novel 5,6-sulfinyl-L-ascorbic acid and its stereoisomers, their manufacture by sulfinylating L-ascorbic acid or corresponding stereoisomers, compositions having oxidation-inhibiting properties which contain 5,6-sulfinyl-L-ascorbic acid or a stereoisomer thereof as well as the use of 5,6-sulfinyl-L-ascorbic acid or a stereoisomer thereof as an antioxidant are described.Type: GrantFiled: June 24, 1988Date of Patent: June 20, 1989Assignee: Hoffmann-La Roche Inc.Inventors: Horst Pauling, Christof Wehrli
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Patent number: 4833259Abstract: The novel sunscreen agents which are esters, namely esters of p-methoxy-cinnamic acid with d,1-.alpha.-tocopherol, pantolactone or panthenol.Type: GrantFiled: August 24, 1987Date of Patent: May 23, 1989Assignee: Hoffmann-La Roche Inc.Inventors: Gustav Erlemann, Christian Fizet, Horst Pauling
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Patent number: 4687859Abstract: A novel process for the manufacture of the optically active lactone of the formula ##STR1## is described.Type: GrantFiled: May 15, 1985Date of Patent: August 18, 1987Assignee: Hoffmann-La Roche Inc.Inventors: Horst Pauling, Christof Wehrli
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Patent number: 4636566Abstract: A process for the manufacture of intermediates in the synthesis of biotin as well as of biotin itself is described. In this process the side chain is attached to the ring system by means of a Grignard reaction, the resulting compound is then dehydrated and subsequently reduced.Type: GrantFiled: February 26, 1985Date of Patent: January 13, 1987Assignee: Hoffmann-La Roche Inc.Inventors: Wolfgang Holick, Horst Pauling
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Patent number: 4602036Abstract: Aluminium panthenolate and zinc panthenolate, their manufacture and use as topical medicaments are described.Type: GrantFiled: January 14, 1985Date of Patent: July 22, 1986Assignee: Hoffmann-La Roche Inc.Inventors: Alfred Hanck, Horst Pauling
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Patent number: 4514338Abstract: Aluminium panthenolate and zinc panthenolate, their manufacture and use as topical medicaments are described.Type: GrantFiled: January 26, 1983Date of Patent: April 30, 1985Assignee: Hoffmann-La Roche Inc.Inventors: Alfred Hanck, Horst Pauling