Patents by Inventor Horst Thomas

Horst Thomas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified oligonucleotides, their preparation and their use
    Patent number: 6987177
    Abstract: Modified oligonucleotides which possess at least one substituted 7-deazapurine base form more stable hybridization complexes with nucleic acids than unsubstituted analogs. They are useful as inhibitors of gene expression, as probes for detecting nucleic acids, as aids in molecular biology and as pharmaceuticals or diagnostic agents. Processes for preparing them are provided.
    Type: Grant
    Filed: August 19, 2002
    Date of Patent: January 17, 2006
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Frank Seela, Horst Thomas
  • Modified oligonucleotides, their preparation and their use
    Publication number: 20030096981
    Abstract: Modified oligonucleotides which possess at least one substituted 7-deazapurine base form more stable hybridization complexes with nucleic acids than unsubstituted analogs. They are useful as inhibitors of gene expression, as probes for detecting nucleic acids, as aids in molecular biology and as pharmaceuticals or diagnostic agents. Processes for preparing them are provided.
    Type: Application
    Filed: August 19, 2002
    Publication date: May 22, 2003
    Inventors: Frank Seela, Horst Thomas
  • Modified oligonucleotides, their preparation and their use
    Patent number: 6479651
    Abstract: Modified oligonucleotides which possess at least one substituted 7-deazapurine base form more stable hybridization complexes with nucleic acids than unsubstituted analogs. They are useful as inhibitors of gene expression, as probes for detecting nucleic acids, as aids in molecular biology and as pharmaceuticals or diagnostic agents. Processes for preparing them are provided.
    Type: Grant
    Filed: August 22, 2000
    Date of Patent: November 12, 2002
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Frank Seela, Horst Thomas
  • Modified oligonucleotides, their preparation and their use
    Patent number: 6150510
    Abstract: Modified oligonucleotides which possess at least one substituted 7-deazapurine base form more stable hybridization complexes with nucleic acids than unsubstituted analogs. They are useful as inhibitors of gene expression, as probes for detecting nucleic acids, as aids in molecular biology and as pharmaceuticals or diagnostic agents. Processes for preparing them are provided.
    Type: Grant
    Filed: August 31, 1998
    Date of Patent: November 21, 2000
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Frank Seela, Horst Thomas
  • Modified oligonucleotides, their preparation and their use
    Patent number: 5844106
    Abstract: Modified oligonucleotides which possess at least one substituted 7-deazapurine base form more stable hybridization complexes with nucleic acids than unsubstituted analogs. They are useful as inhibitors of gene expression, as probes for detecting nucleic acids, as aids in molecular biology and as pharmaceuticals or diagnostic agents.
    Type: Grant
    Filed: November 6, 1995
    Date of Patent: December 1, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Frank Seela, Horst Thomas