Abstract: DNA sequences for human matrix metalloproteases are disclosed, as well as homologous DNA sequences homologous and derived therefrom. Also disclosed are the proteins and protein variants coded by these DNA sequences, there expression, preparation and use. The invention has applications in the fields of biomolecular, medical and pharmaceutical research, for medical diagnosis and therapy, and in the pharmaceutical and biotechnological industry.

Abstract: The invention relates to matrix metalloproteases and variants thereof and DNA sequences that encode these matrix metalloproteases. The invention further relates to obtaining the matrix metalloproteases from natural sources or by recombinant methods by expression of the DNA sequences. These matrix metalloproteases can also complexed with a ligand. The matrix metalloproteases are enzymes that hydrolyze one or more proteins of the extracellular matrix and are thought to contribute to local degradation of the extracellular matrix in tumor cell invasion and metastasis, rheumatoid arthritis, aneurysm formation, smooth muscle proliferation and migration processes in atherosclerotic disease.

Abstract: A solid optical lead formed by a light waveguide having at least two coatings composed of plastic material having an outer layer which is applied directly on the inner layer and is constructed as a flame-retardant layer. The outer layer is constructed as a halogen-free material and comprises an additive that will prevent an adhesion between the outer layer and the inner layer and, thus, assures a good strippability of the outer layer from the inner layer.

Abstract: A heat-shrinkable sleeve which has a shrinkable component and comprises a cross-linked polymer in the form of an open grid, said shrinkable component being embedded into a non-shrinkable component. The individual elements forming the open grid create a plurality of grid cells and are undetachably connected to one another at the point of intersection of the elements.