Patents by Inventor Hoshimi Kawaguchi

Hoshimi Kawaguchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detection of citrullinated inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4)
    Patent number: 11774447
    Abstract: This invention provides a method for diagnosis of rheumatoid arthritis of a subject, a method for assisting diagnosis of rheumatoid arthritis, and a method for monitoring disease activity of rheumatoid arthritis and/or therapeutic effects of an agent for rheumatoid arthritis, comprising detecting citrullination of an arginine residue of the inter-?-trypsin inhibitor heavy chain (ITIH) 4 in a biological sample obtained from the subject. This invention also provides a citrullinated protein derived from the protein having the amino acid sequence as shown in SEQ ID NO: 1 or 5 by modification of arginine 438 into citrulline or a fragment thereof, an antibody binding to such citrullinated protein, and an agent for diagnosis of rheumatoid arthritis comprising such antibody.
    Type: Grant
    Filed: July 2, 2018
    Date of Patent: October 3, 2023
    Assignee: University of Tsukuba
    Inventors: Isao Matsumoto, Takayuki Sumida, Hoshimi Kawaguchi
  • Diagnostic Agent for Rheumatoid Arthritis
    Publication number: 20200173990
    Abstract: This invention provides a method for diagnosis of rheumatoid arthritis of a subject, a method for assisting diagnosis of rheumatoid arthritis, and a method for monitoring disease activity of rheumatoid arthritis and/or therapeutic effects of an agent for rheumatoid arthritis, comprising detecting citrullination of an arginine residue of the inter-?-trypsin inhibitor heavy chain (ITIH) 4 in a biological sample obtained from the subject. This invention also provides a citrullinated protein derived from the protein having the amino acid sequence as shown in SEQ ID NO: 1 or 5 by modification of arginine 438 into citrulline or a fragment thereof, an antibody binding to such citrullinated protein, and an agent for diagnosis of rheumatoid arthritis comprising such antibody.
    Type: Application
    Filed: July 2, 2018
    Publication date: June 4, 2020
    Applicant: University of Tsukuba
    Inventors: Isao Matsumoto, Takayuki Sumida, Hoshimi Kawaguchi