Patents by Inventor Hoshin Kim

Hoshin Kim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PHARMACEUTICALLY ACTIVE PYRAZOLO-PYRIDONE MODULATORS OF DCN1/2-MEDIATED CULLIN NEDDYLATION
    Publication number: 20220280488
    Abstract: A DCN1/2-mediated cullin neddylation modulator; a method for treating disorders associated with dysfunctional DCN1 and/or UBC12, Alzheimer's disease, other neurodegenerative diseases, bacterial infections, or viral infections; and a method for treating cancers are provided. The DCN1/2-mediated cullin neddylation modulator includes a compound according to Formula I disclosed herein. The methods include administering to a mammal a therapeutically effective amount of a compound according to Formula I. Also provided herein is a pharmaceutical composition including a therapeutically effective amount of a compound according to Formula I, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: June 22, 2020
    Publication date: September 8, 2022
    Applicants: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, MEMORIAL SLOAN-KETTERING CANCER CENTER, St. Jude Children's Research Hospital, Inc.
    Inventors: Hoshin KIM, Rodney Kiplin GUY, Jared T. HAMMILL, Daniel Charles SCOTT, Benda Arlene SCHULMAN, Bhuvanesh SINGH
  • CALB Variants
    Publication number: 20180312823
    Abstract: The invention relates to amino acid sequence variants of a lipase with improved activity for catalyzing synthesis reactions and methods of preparing the variants. The methods include predicting amino acid sites for change based on computational models of the protein structure in non-aqueous conditions, and expressing the protein in a prokaryotic host for subsequent purification and use. The enzyme sequence variants described have a three to nine-fold improvement in synthesis activity over the parent protein sequence.
    Type: Application
    Filed: July 9, 2018
    Publication date: November 1, 2018
    Applicants: Eastman Chemical Company, North Carolina State University
    Inventors: Stephanie Kay Clendennen, Yaroslava Georgievna Yingling, Hoshin Kim
  • CALB variants
    Patent number: 10035995
    Abstract: The invention relates to amino acid sequence variants of a lipase with improved activity for catalyzing synthesis reactions and methods of preparing the variants. The methods include predicting amino acid sites for change based on computational models of the protein structure in non-aqueous conditions, and expressing the protein in a prokaryotic host for subsequent purification and use. The enzyme sequence variants described have a three to nine-fold improvement in synthesis activity over the parent protein sequence.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: July 31, 2018
    Assignees: Eastman Chemical Company, North Carolina State University
    Inventors: Stephanie Kay Clendennen, Yaroslava Georgievna Yingling, Hoshin Kim
  • CALB Variants
    Publication number: 20170159034
    Abstract: The invention relates to amino acid sequence variants of a lipase with improved activity for catalyzing synthesis reactions and methods of preparing the variants. The methods include predicting amino acid sites for change based on computational models of the protein structure in non-aqueous conditions, and expressing the protein in a prokaryotic host for subsequent purification and use. The enzyme sequence variants described have a three to nine-fold improvement in synthesis activity over the parent protein sequence.
    Type: Application
    Filed: December 7, 2015
    Publication date: June 8, 2017
    Applicants: Eastman Chemical Company, North Carolina State University
    Inventors: Stephanie Kay Clendennen, Yaroslava Georgievna Yingling, Hoshin Kim