Patents by Inventor Hossein Ardehali

Hossein Ardehali has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR TREATMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION
    Publication number: 20240238243
    Abstract: Disclosed are methods and compositions for treating or preventing heart failure with preserved ejection fraction that involve administering an O-linked N-acetylglucosamine transferase (OGT) inhibitor, for example 5S-GlcNHex, or increasing O-linked N-acetylglucosaminase (OGA) expression in endothelial cells in the heart.
    Type: Application
    Filed: January 12, 2024
    Publication date: July 18, 2024
    Inventors: Hossein Ardehali, Yuki Tatekoshi
  • CLOTRIMAZOLE AS A TREATMENT FOR IMMUNODEFICIENCY DISORDERS
    Publication number: 20240216336
    Abstract: Disclosed are methods for the treatment of immunodeficiency diseases or disorders in subjects in need thereof by administering to the subject an effective amount of a therapeutic agent that results in dissociation of hexokinase 1 (HK1) from the outer membrane of mitochondria and into the cytosol of macrophage cells in the subject and results in inducing a hyperinflammatory response in the subject.
    Type: Application
    Filed: July 28, 2021
    Publication date: July 4, 2024
    Inventors: Hossein Ardehali, Adam De Jesus
  • Mitochondrial lipid permeable iron chelators for treating and preventing ischemia/reperfusion (I/R) injury in the heart following an ischemic event
    Patent number: 10258612
    Abstract: Disclosed are methods and compositions for treating or preventing a disease or disorder responsive to a decrease in baseline mitochondrial iron in a subject in need thereof. The methods typically include administering a pharmaceutical composition comprising a mitochondrial permeable iron chelator to the subject.
    Type: Grant
    Filed: July 13, 2016
    Date of Patent: April 16, 2019
    Assignee: Northwestern University
    Inventors: Hossein Ardehali, Hsiang-Chun Chang
  • IRON CHELATORS FOR TREATING AND PREVENTING CELL DEATH AND ORGAN DAMAGE FOLLOWING AN ISCHEMIC EVENT
    Publication number: 20170014397
    Abstract: Disclosed are methods and compositions for treating or preventing a disease or disorder responsive to a decrease in baseline mitochondrial iron in a subject in need thereof. The methods typically include administering a pharmaceutical composition comprising a mitochondrial permeable iron chelator to the subject.
    Type: Application
    Filed: July 13, 2016
    Publication date: January 19, 2017
    Applicant: Northwestern University
    Inventors: Hossein Ardehali, Hsiang-Chun Chang