Patents by Inventor Hou-Sen Lim

Hou-Sen Lim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11864999
    Abstract: The present invention discloses a core assembly, a sheath assembly, a sheath, a sheath processing method and an interventional instrument delivery system and method. A core assembly for delivering an interventional instrument according to the present invention comprises a core tube, a locking member fixed at a distal end of the core tube for connecting the interventional instrument, and a bendable adjustable tube mounted around an outer periphery of the core tube, wherein the distal ends of the bendable adjustable tube and the core tube are fixedly connected to each other, and the proximal ends can slide relative to each other.
    Type: Grant
    Filed: April 22, 2021
    Date of Patent: January 9, 2024
    Assignee: Venus Medtech (Hangzhou) Inc
    Inventors: Zhifei Zhang, Jianan Wang, Yu Zhang, Zhenjun Zi, Frank Min Zeng, Hou-Sen Lim
  • Publication number: 20230330306
    Abstract: Provided are a pro-endothelialization biological material and method for preparation thereof, and a pro-endothelialization heart valve and method for preparation thereof and interventional system. The pro-endothelialization biological material comprises a biological material and a pro-endothelializing growth factor loaded on the surface of biological material; capable of capturing endothelial progenitor cells, enabling the endothelial progenitor cells to attach, grow, and differentiate on the surface of the biological material. The methods for preparation of the pro-endothelialization biological material comprises chemical grafting and physical coating methods. The heart valve can be prepared either by suturing followed by grafting or by grafting followed by suturing. A endothelial growth factor is directly loaded onto the surface of a biological material film, promoting the formation of endothelial cell layers on the surface of the biological material.
    Type: Application
    Filed: June 19, 2023
    Publication date: October 19, 2023
    Applicant: VENUS MEDTECH (HANGZHOU) INC.
    Inventors: Zhaogang Liu, Yuting Zhu, Dajun Kuang, Hou-Sen Lim
  • Publication number: 20230330300
    Abstract: A biological material is provided and prepared by performing (a) oxidation, (b) first cross-linking, (c) second cross-linking, and (d) dehydration on a biological material for preparation; wherein (b) is performed after (a), and (a), (b), and (c) are all performed prior to (d); during oxidation, an oxidizing agent able to cause hydroxy groups to be converted to aldehyde groups is utilized, the hydroxy groups coming from mucopolysaccharides in the biological material; during first cross-linking, a first cross-linking agent able to cause cross-linking between aldehyde groups of mucopolysaccharides is utilized; and during second cross-linking, a second cross-linking agent able to cause cross-linking between collagen fibers in the biological material is utilized.
    Type: Application
    Filed: June 19, 2023
    Publication date: October 19, 2023
    Applicant: VENUS MEDTECH (HANGZHOU) INC.
    Inventors: Xing Wei, Hou-Sen Lim, Dajun Kuang
  • Publication number: 20220339419
    Abstract: A hemostasis valve, a catheter sheath, and a method for sealing an interventional instrument (9), the hemostasis valve comprising a housing (1,100) and a sealing film (2,130) which is installed within the housing (1,100) and which is a tubular structure; an inner cavity (21) of the tubular structure serves as an instrument channel (11,131) and penetrates the housing (1,100); driving chambers (12,150) which are located on the periphery of the sealing film (2,130) and which are used for being filled with a fluid are provided within the housing (1,100); the hemostasis valve further comprises an energy storage mechanism (3) that can link with the fluid; the energy storage mechanism (3) correspondingly stores or releases energy when the state of the sealing film (2,130) changes; and the sealing film (2,130) is driven to seal the instrument channel (11,131) during energy release.
    Type: Application
    Filed: June 30, 2022
    Publication date: October 27, 2022
    Applicant: VENUS MEDTECH (HANGZHOU) CO., LTD
    Inventors: Xiang Wang, Yintao Zhao, Rongjun Lei, Feng Guo, Hou-Sen Lim
  • Patent number: 11439525
    Abstract: The present invention relates to a device (3) intended to be attached to or interconnected with a medical implant (1), and intended to be attached to or interconnected with a catheter (5), the catheter (5) being intended for implanting the implant (1). The invention further relates to a catheter (5) suited for receiving at least one such device (3) and to a method.
    Type: Grant
    Filed: August 23, 2019
    Date of Patent: September 13, 2022
    Assignee: Venus Medtech (Hangzhou) Inc.
    Inventors: Wolfgang Goetz, Hou-Sen Lim
  • Publication number: 20220096228
    Abstract: A method of reshaping a severely stenosed aortic valve having leaflets with bicuspid malformation and severe calcification. The method includes delivering a balloon with an expandable distal end to the aortic valve, expanding the balloon so that the distal end of the balloon is expanded to push the leaflets upward from bottom of the aortic valve to reshape the leaflets, and forming a space compliant to a self-expandable interventional valve for release, thereby facilitating the following TAVR procedure, reducing the adverse consequences of the TAVR procedure, and improving the surgical stability and the surgical prognosis.
    Type: Application
    Filed: January 29, 2019
    Publication date: March 31, 2022
    Inventors: Mao Chen, Yuan Feng, Zhenjun Zi, Zhengang Zhao, Hou-Sen Lim
  • Publication number: 20220000615
    Abstract: The present invention discloses a core assembly, a sheath assembly, a sheath, a sheath processing method and an interventional instrument delivery system and method. A core assembly for delivering an interventional instrument according to the present invention comprises a core tube, a locking member fixed at a distal end of the core tube for connecting the interventional instrument, and a bendable adjustable tube mounted around an outer periphery of the core tube, wherein the distal ends of the bendable adjustable tube and the core tube are fixedly connected to each other, and the proximal ends can slide relative to each other.
    Type: Application
    Filed: April 22, 2021
    Publication date: January 6, 2022
    Applicant: VENUS MEDTECH (HANGZHOU), INC.
    Inventors: Zhifei Zhang, Jianan Wang, Yu Zhang, Zhenjun Zi, Frank Min Zeng, Hou-Sen Lim
  • Publication number: 20210268151
    Abstract: A pre-loadable biological heart valve capable of rapid rehydration and a preparation method thereof. The preparation method comprises a cross-linking treatment, wherein a biological valve is cross-linked by soaking in an aqueous glutaraldehyde solution; a hydrophilic treatment, wherein the biological valve is soaked in a solution containing a hydrophilic molecule and a condensing agent, to allow the hydrophilic molecule to be immobilized on the biological valve by chemical grafting; and a drying treatment, wherein the biological valve after the hydrophilic treatment and the cross-linking treatment is dried to obtain a pre-loadable biological heart valve capable of rapid rehydration. The pre-loadable biological heart valve prepared by the preparation method of the present disclosure achieves rapid rehydration, and the crease can be quickly flattened after rehydration, bringing convenience during use.
    Type: Application
    Filed: May 6, 2021
    Publication date: September 2, 2021
    Applicants: VENUS MEDTECH (HANGZHOU), INC., Sichuan University
    Inventors: Yunbing Wang, Gaocan Li, Yang Lei, Li Yang, Hou-Sen Lim, Dajun Kuang, Jincheng Yu
  • Publication number: 20210260247
    Abstract: A pre-loadable dried biological heart valve and a preparation method thereof. The preparation method includes: Step A: soaking a fresh animal pericardium in an aqueous solution of soluble elastin or glycosaminoglycan, and then subjecting the pericardium to a first cross-linking reaction in a mixed solution of carbodiimide or N-hydroxysuccinimide to allow the soluble elastin or glycosaminoglycan to bind to the pericardium via a chemical bond; and Step B: subjecting the pericardium after the first cross-linking to a second cross-linking reaction in an aqueous glutaraldehyde solution, and then drying the pericardium after the second cross-linking, to obtain the pre-loadable dried biological heart valve. The dried biological heart valve obtained by the above preparation method has good toughness, and is rapidly flattened out in a simulated folding and pressing test.
    Type: Application
    Filed: May 6, 2021
    Publication date: August 26, 2021
    Applicants: VENUS MEDTECH (HANGZHOU), INC., Sichuan University
    Inventors: Yunbing Wang, Yang Lei, Gaocan Li, Li Yang, Hou-Sen Lim, Dajun Kuang, Jincheng Yu
  • Patent number: 11000371
    Abstract: The present invention relates to an apparatus (3) for use during implanting at least one medical implant (6) at an implantation site within a patient's body, wherein the apparatus (3) comprises an aligning device (9) for aligning the apparatus (3) at the implantation site, wherein the aligning device (9) is capable of being transferred from a non-aligning position into an aligning position. It further relates to a set and a method.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: May 11, 2021
    Assignee: Venus Medtech Hangzhou Inc
    Inventors: Wolfgang Goetz, Hou-Sen Lim
  • Publication number: 20200289258
    Abstract: Heart valve comprising a crown piece interconnected to leaflets, a top cuff and a bottom cuff; and a medical implant. The present invention relates to a heart valve (100), comprising at least two leaflets (101, 101?, 101?); at least one crown piece (111) interconnected to the leaflets (101, 101?, 101?) and intended to be interconnected to a frame (1) of a medical implant or a heart valve assembly; a top cuff (121); and a bottom cuff (131), the crown piece (111), the top cuff (121) and the bottom cuff (131) each being ring-shaped, and each of the top cuff (121) and the bottom cuff (131) being interconnected with the crown piece (111).
    Type: Application
    Filed: May 31, 2020
    Publication date: September 17, 2020
    Applicant: VENUS MEDTECH (HANGZHOU), INC.
    Inventors: Hou-Sen Lim, Wolfgang Gotz
  • Patent number: 10736744
    Abstract: The present invention relates to a handle assembly (100) for an implant delivery device for folding or unfolding at least one medical implant by means of at least one tension thread, wherein the handle assembly (100) comprises a drum (14) for winding the tension thread thereon by rotating the drum (14); a knob (9) to be rotated by a user of the handle assembly (100) in order to fold or unfold the medical implant by tightening or winding the tension thread or by releasing or unwinding the tension thread, the knob (9) being arranged or interconnected with the drum (14) such that the drum (14) may be rotated when the knob (9) is rotated; and a brake frame assembly (25) comprising at least one brake element and at least one spring (256, 257) arranged to act on the brake element such that the brake elements contact one surface of the rear knob (9).
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: August 11, 2020
    Assignee: Venus Medtech (Hangzhou) Inc
    Inventors: Hou-Sen Lim, Wolfgang Gotz
  • Patent number: 10736743
    Abstract: The present invention relates to a handle assembly (100) for an implant delivery device for folding or unfolding at least one medical implant by means of at least one tension thread, wherein the handle assembly (100) comprises a drum (14) for winding the tension thread thereon by rotating the drum (14); a knob (9) to be rotated by a user of the handle assembly (100) in order to fold or unfold the medical implant, the knob (9) being interconnected with the drum (14) such that the drum (14) is rotated when the knob (9) is rotated; and a displacement limiter for limiting the length or displacement by which the tension thread (11) may be at least one of wound onto or unwound from the drum (14) by rotating the knob (9).
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: August 11, 2020
    Assignee: Venus Medtech (Hangzhou) Inc.
    Inventors: Hou-Sen Lim, Wolfgang Gotz
  • Publication number: 20200046530
    Abstract: The present invention relates to a device (3) intended to be attached to or interconnected with a medical implant (1), and intended to be attached to or interconnected with a catheter (5), the catheter (5) being intended for implanting the implant (1). The invention further relates to a catheter (5) suited for receiving at least one such device (3) and to a method.
    Type: Application
    Filed: August 23, 2019
    Publication date: February 13, 2020
    Applicant: VENUS MEDTECH (HANGZHOU), INC.
    Inventors: Wolfgang Goetz, Hou-Sen Lim
  • Patent number: 10493573
    Abstract: A method for crimping a medical implant includes at least one foldable and/or unfoldable structure on or around or over a portion or outer surface of a catheter or of a catheter tip. No pressure beyond a predetermined pressure is exerted on the structure during and/or after crimping of the implant.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: December 3, 2019
    Assignee: Venus Medtech (Hangzhou) Inc.
    Inventors: Wolfgang Goetz, Hou-Sen Lim
  • Patent number: 10463483
    Abstract: A collapsible-expandable tubular stent (29) constructed of shape-memory material which is implantable into a human heart, which comprises proximal and distal rings (71, 73) and at least two spaced apart posts (69) that extend axially between said rings (71, 73), said distal ring (73) comprising a plurality of distal arms (77) which are connected to the distal ring (73) at only one end and which have a free opposite end; said proximal ring (71) comprising a plurality of, which are connected at only one end to the proximal ring (71) and which have a free opposite end, which proximal arms (75) are constructed to swing radially outward at their free ends.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: November 5, 2019
    Assignee: Venus Medtech (Hangzhou) Inc.
    Inventors: Hou-Sen Lim, Wolfgang Gotz
  • Patent number: 10390981
    Abstract: A device is intended to be attached to or interconnected with a medical implant, and intended to be attached to or interconnected with a catheter. The catheter is intended for implanting the implant.
    Type: Grant
    Filed: February 16, 2011
    Date of Patent: August 27, 2019
    Assignee: Venus Medtech (Hangzhou) Inc.
    Inventors: Wolfgang Goetz, Hou-Sen Lim
  • Patent number: 10292843
    Abstract: An implant, intended to be detachably fixed or crimped on a portion or an outer surface of a catheter for being delivered to an implantation site, includes a longitudinal axis, or an inner space or inner volume longitudinally extending within the implant, and a radial direction perpendicular to the longitudinal axis, space or volume. The implant includes a first structural element having a first portion, a second structural element having a second portion, and one or more interconnecting elements arranged between the first and the second structural elements. In the implant, the first portion and/or the second portion is/are located less radially as regards the longitudinal axis, inner space, or volume than a third portion of the one or more interconnecting elements.
    Type: Grant
    Filed: February 16, 2011
    Date of Patent: May 21, 2019
    Assignee: Venus Medtech (Hangzhou) Inc.
    Inventors: Wolfgang Goetz, Hou-Sen Lim
  • Publication number: 20190060066
    Abstract: The present invention relates to an apparatus (3) for use during implanting at least one medical implant (6) at an implantation site within a patient's body, wherein the apparatus (3) comprises an aligning device (9) for aligning the apparatus (3) at the implantation site, wherein the aligning device (9) is capable of being transferred from a non-aligning position into an aligning position. It further relates to a set and a method.
    Type: Application
    Filed: October 30, 2018
    Publication date: February 28, 2019
    Inventors: Wolfgang GOETZ, Hou-Sen LIM
  • Patent number: 10188537
    Abstract: The present invention relates to an apparatus (100) for folding or unfolding at least one medical implant (300) by using at least one tension thread (11, 11?), wherein the apparatus (100) includes a shaft (1) including a reception area (55) for receiving the implant (300), and a tensioning device for altering a shape of the foldable and/or unfoldable implant (300) by the tension thread (11, 11?).
    Type: Grant
    Filed: May 14, 2014
    Date of Patent: January 29, 2019
    Assignee: Venus Medtech (Hangzhou) Inc.
    Inventors: Hou-Sen Lim, Wolfgang Goetz