Patents by Inventor Houguang Shi

Houguang Shi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FREE AMINO COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION
    Publication number: 20210323981
    Abstract: The present invention relates to novel compounds of formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: May 20, 2021
    Publication date: October 21, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Hong SHEN, Xuefei TAN, Chengang ZHOU, Mingwei ZHOU, Yimin HU, Houguang SHI, Fabian DEY, Yongqiang LIU, Xiao DING
  • ARYL COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION
    Publication number: 20210309658
    Abstract: The present invention relates to novel compounds of formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: May 26, 2021
    Publication date: October 7, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Fabian DEY, Yimin HU, Yongqiang LIU, Hong SHEN, Houguang SHI, Xuefei TAN, Shixiang YAN, Weixing ZHANG, Zhiwei ZHANG, Chengang ZHOU, Mingwei ZHOU, Wei ZHU
  • TRICYCLIC COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION
    Publication number: 20210309657
    Abstract: The present invention relates to novel compounds of formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: May 26, 2021
    Publication date: October 7, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Fabian DEY, Yimin HU, Yongqiang LIU, Hong SHEN, Houguang SHI, Xuefei TAN, Shixiang YAN, Weixing ZHANG, Zhiwei ZHANG, Chengang ZHOU, Mingwei ZHOU, Wei ZHU
  • NOVEL OXOQUINOLIZINE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION
    Publication number: 20210238197
    Abstract: The present invention relates to novel compounds of formula (I), wherein R1, R2, R3, R4, R5, R6 and R7 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: November 25, 2020
    Publication date: August 5, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Fabian Dey, Xiao Ding, Yimin Hu, Yongqiang Liu, Hong Shen, Houguang Shi, Xuefei Tan, Chengang Zhou, Mingwei Zhou
  • SUBSTITUTED PYRIDOINDOLES FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION
    Publication number: 20210221832
    Abstract: The present invention relates to novel compounds of formula (I) or (II), wherein R1 to R6, R11 to R17 are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: March 25, 2021
    Publication date: July 22, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Xiao DING, Yongqiang LIU, Hong SHEN, Houguang SHI, Xuefei TAN, Chengang ZHOU, Mingwei ZHOU
  • Novel pyrido[2,3-b]indole compounds for the treatment and prophylaxis of bacterial infection
    Publication number: 20200339603
    Abstract: The present invention relates to novel compounds of formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: April 29, 2020
    Publication date: October 29, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Yimin Hu, Chengang Zhou, Mingwei Zhou, Houguang Shi, Yongqiang Liu, Hong Shen, Maarten Vercruysse, Shixiang Yan, Xuefei Tan, Xianfeng Lin, Fabian Dey
  • Pyrido[2,3-b]indole compounds for the treatment and prophylaxis of bacterial infection
    Patent number: 10662203
    Abstract: The present invention relates to novel compounds of formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: May 26, 2020
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Yimin Hu, Chengang Zhou, Mingwei Zhou, Houguang Shi, Yongqiang Liu, Hong Shen, Maarten Vercruysse, Shixiang Yan, Xuefei Tan, Xianfeng Lin, Fabian Dey
  • 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
    Publication number: 20200062753
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R6, X, Y, W and n are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: August 5, 2019
    Publication date: February 27, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Lei Guo, Taishan Hu, Buyu Kou, Xianfeng Lin, Hong Shen, Houguang Shi, Shixiang Yan, Weixing Zhang, Zhisen Zhang, Mingwei Zhou, Wei Zhu
  • 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
    Patent number: 10428069
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R6, X, Y, W and n are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: August 14, 2018
    Date of Patent: October 1, 2019
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Lei Guo, Taishan Hu, Buyu Kou, Xianfeng Lin, Hong Shen, Houguang Shi, Shixiang Yan, Weixing Zhang, Zhisen Zhang, Mingwei Zhou, Wei Zhu
  • Novel 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
    Publication number: 20180370969
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R6, X, Y, W and n are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: August 14, 2018
    Publication date: December 27, 2018
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Lei Guo, Taishan Hu, Buyu Kou, Xianfeng Lin, Hong Shen, Houguang Shi, Shixiang Yan, Weixing Zhang, Zhisen Zhang, Mingwei Zhou, Wei Zhu
  • Novel pyrido[2,3-b]indole compounds for the treatment and prophylaxis of bacterial infection
    Publication number: 20180327425
    Abstract: The present invention relates to novel compounds of formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: March 30, 2018
    Publication date: November 15, 2018
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Yimin Hu, Chengang Zhou, Mingwei Zhou, Houguang Shi, Yongqiang Liu, Hong Shen, Maarten Vercruysse, Shixiang Yan, Xuefei Tan, Xianfeng Lin, Fabian Dey
  • 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
    Patent number: 10081627
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R6, X, Y, W and n are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: September 25, 2018
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Lei Guo, Taishan Hu, Buyu Kou, Xianfeng Lin, Hong Shen, Houguang Shi, Shixiang Yan, Weixing Zhang, Zhisen Zhang, Mingwei Zhou, Wei Zhu
  • 6-bridged heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
    Patent number: 9758530
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as or pharmaceutically acceptable salts, or tautomerism isomers, or enantiomers, or diastereomers thereof. The invention also contains compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: September 12, 2017
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Lei Guo, Taishan Hu, Yimin Hu, Buelent Kocer, Buyu Kou, Gangqin Li, Xianfeng Lin, Haixia Liu, Hong Shen, Houguang Shi, Guolong Wu, Zhisen Zhang, Mingwei Zhou, Wei Zhu
  • NOVEL 6-BRIDGED HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
    Publication number: 20160122363
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as or pharmaceutically acceptable salts, or tautomerism isomers, or enantiomers, or diastereomers thereof. The invention also contains compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: January 8, 2016
    Publication date: May 5, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Lei Guo, Taishan Hu, Yimin Hu, Buelent Kocer, Buyu Kou, Gangqin Li, Xianfeng Lin, Haixia Liu, Hong Shen, Houguang Shi, Guolong Wu, Zhisen Zhang, Mingwei Zhou, Wei Zhu
  • Novel 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
    Publication number: 20160083383
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R6, X, Y, W and n are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: November 19, 2015
    Publication date: March 24, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Lei Guo, Taishan Hu, Buyu Kou, Xianfeng Lin, Hong Shen, Houguang Shi, Shixiang Yan, Weixing Zhang, Zhisen Zhang, Mingwei Zhou, Wei Zhu
  • 6-bridged heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
    Patent number: 9266904
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as or pharmaceutically acceptable salts, or tautomerism isomers, or enantiomers, or diastereomers thereof. The invention also contains compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: May 16, 2014
    Date of Patent: February 23, 2016
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Lei Guo, Taishan Hu, Yimin Hu, Buelent Kocer, Buyu Kou, Gangqin Li, Xianfeng Lin, Haixia Liu, Hong Shen, Houguang Shi, Guolong Wu, Zhisen Zhang, Mingwei Zhou, Wei Zhu
  • 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
    Patent number: 9233978
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R6, X, Y, W and n are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: January 12, 2016
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Lei Guo, Taishan Hu, Buyu Kou, Xianfeng Lin, Hong Shen, Houguang Shi, Shixiang Yan, Weixing Zhang, Zhisen Zhang, Mingwei Zhou, Wei Zhu
  • Novel 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
    Publication number: 20150252057
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R6, X, Y, W and n are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: March 6, 2015
    Publication date: September 10, 2015
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Lei Guo, Taishan Hu, Buyu Kou, Xianfeng Lin, Hong Shen, Houguang Shi, Shixiang Yan, Weixing Zhang, Zhisen Zhang, Mingwei Zhou, Wei Zhu
  • NOVEL 6-BRIDGED HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
    Publication number: 20140343032
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as or pharmaceutically acceptable salts, or tautomerism isomers, or enantiomers, or diastereomers thereof. The invention also contains compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: May 16, 2014
    Publication date: November 20, 2014
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Lei Guo, Taishan Hu, Yimin Hu, Buelent Kocer, Buyu Kou, Gangqin Li, Xianfeng Lin, Haixia Liu, Hong Shen, Houguang Shi, Guolong Wu, Zhisen Zhang, Mingwei Zhou, Wei Zhu