Abstract: A system for processing, communication and viewing of medical imaging study data is configured to process and communicate medical imaging study data for communication between a local system and a client terminal. The systems preferably include a local system, one or more client terminals and an intermediate remote server. The local system may be located within a Virtual Private Network (VPN) and includes a local or site server, a Picture Archiving and Communication System (PACS) and a Radiology Information System (RIS). The local or site server communicates between the PACS and the RIS, and the intermediate remote server that may be outside of the VPN. The local or site server may be configured to perform a lossless image processing method to process, compress and encrypt and communicate medical imaging study data. An interface and associated methods of viewing medical imaging study data are also disclosed.