Patents by Inventor Hovsep S. Melkonyan
Hovsep S. Melkonyan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20180135126Abstract: Described are non-invasive methods of detecting in vivo cell death by measuring levels of ubiquitous and tissue specific miRNA. The method can be applied for detection of pathologies caused or accompanied by cell death, as well as for diagnosis of infectious disease, cytotoxic effects induced by different chemical or physical factors, and the presence of specific fetal abnormalities.Type: ApplicationFiled: January 6, 2017Publication date: May 17, 2018Inventors: Samuil R. Umansky, Hovsep S. Melkonyan, Vladimir S. Scheinker
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Patent number: 9909118Abstract: This invention provides compositions and methods for rapid separation, isolation and purification of nucleic acids from biological samples using anionic exchange media. The method can utilize commercially available strong or weak anion exchanger materials with selected solutions of known ionic strength for adsorption and elution. The instant method is particularly advantageous as it permits the purification and identification of shorter fragments of nucleic acids from bodily fluids which, until now, had not been identified.Type: GrantFiled: April 30, 2015Date of Patent: March 6, 2018Assignee: Trovagene, Inc.Inventors: Samuil R Umansky, Hovsep S Melkonyan, Erik Meyer, William John Feaver
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Patent number: 9816148Abstract: The present invention provides highly sensitive methods used for diagnosing and monitoring various diseases and disorders by detecting and analyzing “ultra short” (20-50 base pair) nucleic acids obtained from bodily fluids.Type: GrantFiled: August 6, 2015Date of Patent: November 14, 2017Assignee: Trovagene, Inc.Inventors: Samuil R. Umansky, Hovsep S. Melkonyan, Eugene M. Shekhtman
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Publication number: 20170016078Abstract: The invention provides compositions and methods for the differential detection of high risk forms of HPV from a urine sample provided by a patient. Specifically, the invention provides primers and probes that specifically recognize and bind sequences within the E1 gene of HPV. Detection of high risk forms of HPV identifies individuals at risk of developing or in the early stages of cervical carcinoma.Type: ApplicationFiled: July 25, 2016Publication date: January 19, 2017Applicant: Trovagene, Inc.Inventors: Hovsep S. Melkonyan, Samuil R. Umansky, Zhenghan Xin
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Patent number: 9453265Abstract: The invention provides compositions and methods for the differential detection of high risk forms of HPV from a urine sample provided by a patient. Specifically, the invention provides primers and probes that specifically recognize and bind sequences within the E1 gene of HPV. Detection of high risk forms of HPV identifies individuals at risk of developing or in the early stages of cervical carcinoma.Type: GrantFiled: February 4, 2014Date of Patent: September 27, 2016Assignee: Trovagene, Inc.Inventors: Samuil R. Umansky, Hovsep S. Melkonyan, Zhenghan M. Xin
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Publication number: 20160060717Abstract: The present invention provides highly sensitive methods used for diagnosing and monitoring various diseases and disorders by detecting and analyzing “ultra short” (20-50 base pair) nucleic acids obtained from bodily fluids.Type: ApplicationFiled: May 20, 2013Publication date: March 3, 2016Applicant: TROVAGENE, INC.Inventors: Samuil R. Umansky, Hovsep S. Melkonyan, Eugene M. Shekhtman
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Publication number: 20150329920Abstract: The present invention provides highly sensitive methods used for diagnosing and monitoring various diseases and disorders by detecting and analyzing “ultra short” (20-50 base pair) nucleic acids obtained from bodily fluids.Type: ApplicationFiled: August 6, 2015Publication date: November 19, 2015Applicant: TROVAGENE, INC.Inventors: Samuil R. Umansky, Hovsep S. Melkonyan, Eugene M. Shekhtman
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Publication number: 20150275198Abstract: This invention provides compositions and methods for rapid separation, isolation and purification of nucleic acids from biological samples using anionic exchange media. The method can utilize commercially available strong or weak anion exchanger materials with selected solutions of known ionic strength for adsorption and elution. The instant method is particularly advantageous as it permits the purification and identification of shorter fragments of nucleic acids from bodily fluids which, until now, had not been identified.Type: ApplicationFiled: April 30, 2015Publication date: October 1, 2015Applicant: TROVAGENE, INC.Inventors: Samuil R Umansky, Hovsep S Melkonyan, Erik Meyer, William John Feaver
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Publication number: 20150197805Abstract: Described are non-invasive methods of detecting in vivo cell death by measuring levels of ubiquitous and tissue specific miRNA. The method can be applied for detection of pathologies caused or accompanied by cell death, as well as for diagnosis of infectious disease, cytotoxic effects induced by different chemical or physical factors, and the presence of specific fetal abnormalities.Type: ApplicationFiled: July 16, 2013Publication date: July 16, 2015Inventors: Samuil R. Umansky, Hovsep S. Melkonyan, Vladimir S. Scheinker
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Patent number: 8486626Abstract: Described are non-invasive methods of detecting in vivo cell death by measuring levels of ubiquitous and tissue specific miRNA. The method can be applied for detection of pathologies caused or accompanied by cell death, as well as for diagnosis of infectious disease, cytotoxic effects induced by different chemical or physical factors, and the presence of specific fetal abnormalities.Type: GrantFiled: August 22, 2008Date of Patent: July 16, 2013Assignee: Trovagene, Inc.Inventors: Samuil R. Umansky, Hovsep S. Melkonyan, Vladimir S. Scheinker
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Publication number: 20130178544Abstract: The present invention relates to methods for diagnosis or monitoring of viral infection by detecting the presence of transrenal viral nucleic acids or nucleic acids of viral origin in urine sample, with or without isolation of nucleic acids from a urine sample. The analysis of the nucleic acids is performed through hybridization of the nucleic acids with specific probes, or through a chain amplification reaction with specific primers. The methods are applicable to all viral pathogenic agents, including RNA, DNA, episomal, or integrated viruses.Type: ApplicationFiled: February 26, 2013Publication date: July 11, 2013Applicant: Trovagene, Inc.Inventors: Hovsep S. MELKONYAN, Angela Cannas, Louis David Tomei, Samuil R. Umansky
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Publication number: 20110318727Abstract: The invention provides compositions and methods for the differential detection of high risk forms of HPV from a urine sample provided by a patient. Specifically, the invention provides primers and probes that specifically recognize and bind sequences within the E1 gene of HPV. Detection of high risk forms of HPV identify individuals at risk of developing or in the early stages of cervical carcinoma.Type: ApplicationFiled: October 26, 2009Publication date: December 29, 2011Inventors: Hovsep S. Melkonyan, Samuil R. Umansky, Zhenghan Xin
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Publication number: 20100068711Abstract: The present invention provides highly sensitive methods used for diagnosing and monitoring various diseases and disorders by detecting and analyzing “ultra short” (20-50 base pair) nucleic acids obtained from bodily fluids.Type: ApplicationFiled: July 17, 2009Publication date: March 18, 2010Applicant: Xenomics, Inc.Inventors: Samuil R. Umansky, Hovsep S. Melkonyan, Natalya Ossina, Eugene M. Shekhtman
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Publication number: 20090081640Abstract: Described are non-invasive methods of detecting in vivo cell death by measuring levels of ubiquitous and tissue specific miRNA. The method can be applied for detection of pathologies caused or accompanied by cell death, as well as for diagnosis of infectious disease, cytotoxic effects induced by different chemical or physical factors, and the presence of specific fetal abnormalities.Type: ApplicationFiled: August 22, 2008Publication date: March 26, 2009Inventors: Samuil R. Umansky, Hovsep S. Melkonyan, Vladimir S. Scheinker
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Patent number: 6492144Abstract: Described are non-invasive methods of detecting the presence of specific nucleic acid sequences as well as nucleic acid modifications and alterations by analyzing urine samples for the presence of transrenal nucleic acids. More specifically, the present invention encompasses methods of detecting specific fetal nucleic acid sequences and fetal sequences that contained modified nucleotides by analyzing maternal urine for the presence of fetal nucleic acids. The invention further encompasses methods of detecting specific nucleic acid modifications for the diagnosis of diseases, such as cancer and pathogen infections, and detection of genetic predisposition to various diseases. The invention specifically encompasses methods of analyzing specific nucleic acid modifications for the monitoring of cancer treatment. The invention further encompasses methods of analyzing specific nucleic acids in urine to track the success of transplanted cells, tissues and organs.Type: GrantFiled: August 3, 2000Date of Patent: December 10, 2002Assignee: Diagen CorporationInventors: Samuil R. Umansky, Anatoly V. Lichtenstein, Hovsep S. Melkonyan
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Publication number: 20020119478Abstract: Described are non-invasive methods of detecting the presence of specific nucleic acid sequences as well as nucleic acid modifications and alterations by analyzing urine samples for the presence of transrenal nucleic acids. More specifically, the present invention encompasses methods of detecting specific fetal nucleic acid sequences and fetal sequences that contained modified nucleotides by analyzing maternal urine for the presence of fetal nucleic acids. The invention further encompasses methods of detecting specific nucleic acid modifications for the diagnosis of diseases, such as cancer and pathogen infections, and detection of genetic predisposition to various diseases. The invention specifically encompasses methods of analyzing specific nucleic acid modifications for the monitoring of cancer treatment. The invention further encompasses methods of analyzing specific nucleic acids in urine to track the success of transplanted cells, tissues and organs.Type: ApplicationFiled: November 7, 2001Publication date: August 29, 2002Applicant: Diagen CorporationInventors: Samuil R. Umansky, Anatoly V. Lichtenstein, Hovsep S. Melkonyan
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Patent number: 6287820Abstract: Described are non-invasive methods of detecting and/or quantifying specific nucleic acid sequences by analyzing urine samples for nucleic acids that have crossed the kidney barrier. More specifically, the present invention encompasses methods of analyzing specific fetal nucleic acid sequences by analyzing maternal urine for the presence of fetal nucleic acids. The invention further encompasses methods of analyzing specific nucleic acid alterations for the diagnosis of disease. The invention encompasses methods of analyzing specific nucleic acid alterations for the diagnosis of cancer and the monitoring of its treatment. The invention further encompasses methods of analyzing specific nucleic acids in urine to track the success of transplanted cells, tissues and organs.Type: GrantFiled: July 3, 2000Date of Patent: September 11, 2001Assignee: Diagen CorporationInventors: Samuil R. Umansky, Anatoly V. Lichtenstein, Hovsep S. Melkonyan
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Patent number: 6251638Abstract: Described are non-invasive methods of detecting the presence of specific nucleic acid sequences by analyzing urine samples for the presence of nucleic acids that have crossed the kidney barrier. More specifically, the present invention encompasses methods of detecting specific fetal nucleic acid sequences by analyzing maternal urine for the presence of fetal nucleic acids. The invention further encompasses methods of detecting specific nucleic acid alterations for the diagnosis of disease.Type: GrantFiled: February 4, 2000Date of Patent: June 26, 2001Assignee: Diagen CorporationInventors: Samuil R. Umansky, Anatoly V. Lichtenstein, Hovsep S. Melkonyan
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Patent number: RE39920Abstract: Described are non-invasive methods of detecting the presence of specific nucleic acid sequences as well as nucleic acid modifications and alterations by analyzing urine samples for the presence of transrenal nucleic acids. More specifically, the present invention encompasses methods of detecting specific fetal nucleic acid sequences and fetal sequences that contained modified nucleotides by analyzing maternal urine for the presence of fetal nucleic acids. The invention further encompasses methods of detecting specific nucleic acid modifications for the diagnosis of disease, such as cancer and pathogen infections, and detection of genetic predisposition to various disease. The invention specifically encompasses methods of analyzing specific nucleic acid modifications for the monitoring of cancer treatment. The invention further encompasses methods of analyzing specific nucleic acids in urine to track the success of transplanted cells, tissues and organs.Type: GrantFiled: November 19, 2004Date of Patent: November 13, 2007Assignee: Xenomics, Inc.Inventors: Samuil R. Umansky, Anatoly V. Lichtenstein, Hovsep S. Melkonyan