Patents by Inventor Howard A. Royman

Howard A. Royman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of exogenous &bgr;-adrenergic receptor and &bgr;-adrenergic receptor kinase gene constructs to enhance myocardial function
    Patent number: 6436908
    Abstract: The present invention deals with gene therapy for treating chronic heart failure and other cardiac disease states which are accompanied by a reduced number or functioning of myocardial beta-adrenergic receptors (&bgr;-AR). &bgr;-AR receptor function is augmented in transgenic animals by delivery and expression of a beta-2-adrenergic receptor gene or a gene encoding a beta adrenergic receptor kinase inhibitor, resulting in increased in vivo left ventricular function. The present invention includes recombinant plasmid vectors, alternative beta-adrenergic receptor gene delivery strategies, and transgenic mice carrying a &bgr;-AR transgene, a &bgr;-ARK transgene, or a &bgr;-ARK inhibitor transgene.
    Type: Grant
    Filed: April 5, 1999
    Date of Patent: August 20, 2002
    Assignee: Duke University
    Inventors: Walter J. Koch, Robert J. Lefkowitz, Carmelo A. Milano, Howard A. Royman