Abstract: The present invention relates to a systems and methods for selecting agents and combinations of agents for treatment of particular cancer patients or selected groups of cancer patients. These methods of the invention index possible agents and combinations in a ranking indicating the likelihood of their usefulness in the particular patient or group of patients. The indexing depends on chemo-sensitivity/resistance assays data for the agents and combinations themselves, supplemented by reference data obtained from assaying the same and other agents and combinations against clinically similar tumors, and on overall clinical response rates for the agents and combinations. These methods include additional new indexing criteria which supplement or replace previous criteria in order to provide for more complex, informative and quantitative analysis of potential treatments for single patients or groups of patients.