Abstract: An electroceutical apparatus and self-care method for treating pain by providing Transcutaneous Electrical Nerve Stimulation (TENS) in combination with pulsed Ultrasound or Light Emitting Diode (LED) treatments. In some embodiments, the apparatus includes a pod unit and a controller, and wrap for holding the pod unit on an area of a user's body. In some embodiments, the wrap may include electrodes and the intensity of the TENS treatment may be adjusted by a user via the controller. In some embodiments, the frequency or output of the treatments is fixed and sequentially delivered to the user in a timed manner.

Abstract: Painless, non-invasive nanofluidic delivery systems useful for the delivery of therapeutically active agents, GRAS agents, sterile fluids and inert fillers through epithelial membranes are described. The painless, non-invasive delivery system delivers a therapeutic agent via a micro-syringe-based assembly. The painless, non-invasive delivery system may also have a vehicle, which facilitates the absorption of the therapeutic agents by altering its absorption rate at the site of administration. Also disclosed is a method and components of the delivery system to administer therapeutic agents in a consistent, predictable and reproducible manner. Certain compositions may facilitate the delivery of different agents without altering the agents from their current or previous form.

Abstract: Apparatus for subcutaneously delivering a substance to a patient, said apparatus comprising: a carrier comprising a flexible body, wherein said flexible body comprises a reservoir, and further wherein said reservoir contains the substance which is to be delivered to the patient; a nanoneedle assembly comprising: a tubular body having a distal end and a proximal end; a base plate movably mounted intermediate said distal end and said proximal end of said tubular body, said base plate comprising a distal surface and a proximal surface, with a plurality of through-holes extending between said distal surface and said proximal surface of said base plate, said proximal surface of said base plate being in fluid communication with said reservoir; a plurality of nanoneedles, wherein each of said plurality of nanoneedles comprises a distal end, a proximal end, and a lumen extending therebetween, said proximal end of each of said plurality of nanoneedles being mounted to said base plate such that said lumen of each o