Patents by Inventor Howard C Herrmann

Howard C Herrmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8118866
    Abstract: A percutaneously inserted bistable heart valve prosthesis is folded inside a catheter for transseptal delivery to the patient's heart for implantation. The heart valve has an annular ring, a body member having a plurality of legs, each leg connecting at one end to the annular ring, claws that are adjustable from a first position to a second position by application of external force so as to allow ingress of surrounding heart tissue into the claws in the second position, and leaflet membranes connected to the annular ring, the body member and/or the legs, the leaflet membranes having a first position for blocking blood flow therethrough and a second position for allowing blood flow therethrough. The heart valve is designed such that upon removal of the external force the claws elastically revert to the first position so as to grip the heart tissue positioned within the claws, thereby holding the heart valve in place. The body member and claws may be integrated into a one-piece design.
    Type: Grant
    Filed: October 21, 2009
    Date of Patent: February 21, 2012
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Howard C. Herrmann, Nilesh Mankame, Suresh G. K. Ananthasuresh
  • Patent number: 8070802
    Abstract: Valve prostheses are disclosed that are adapted for secure and aligned placement relative to a heart annulus. The valve prostheses may be placed in a non-invasive manner, e.g., via transcatheter techniques. The valve prosthesis may include a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring. Each of the positioning elements defines respective proximal, intermediate, and distal tissue engaging regions cooperatively configured and dimensioned to simultaneously engage separate corresponding areas of the tissue of an anatomical structure, including respective first, second, and third elongate tissue-piercing elements.
    Type: Grant
    Filed: February 8, 2008
    Date of Patent: December 6, 2011
    Assignees: The Trustees of the University of Pennsylvania, EndoValve, Inc.
    Inventors: David G. Lamphere, Tuan Anh Nguyen, Howard C. Herrmann, Todd C. Tomba, Robert C. Gorman, Joseph H. Gorman, III
  • Patent number: 7998129
    Abstract: A method and device that addresses the problem of an incompetent aortic valve by using a simple cardioplegia catheter that can deliver cardioplegia solution to the coronary arteries through the usual aortic cannulation site even in the presence of aortic valve incompetence. The device includes a cardioplegia cannula (32) with an additional lumen containing a nitinol wire (34) inside it that allows advancement of a folded nitinol umbrella (36) with a non-porous membrane or a compressed nitinol ring that covers the aortic valve when opened. During installation, after puncture of the aorta by the coaxial needle and removal of the coaxial needle but before installation of the cardioplegia solution through the central lumen of the catheter, the nitinol umbrella (in folded position) or nitinol ring (in compressed position) is advanced through the second lumen into the aorta just above the aortic valve.
    Type: Grant
    Filed: March 10, 2005
    Date of Patent: August 16, 2011
    Assignee: The Trustees Of The University Of Pennsylvainia
    Inventors: Howard C Herrmann, Y Joseph Woo
  • Patent number: 7753949
    Abstract: Valve prostheses are disclosed that are adapted for secure and aligned placement relative to a heart annulus. The valve prostheses may be placed in a non-invasive manner, e.g., via trans-catheter techniques, and may be positioned/repositioned until proper alignment and positioning is achieved. The valve prosthesis may include a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring, each of the positioning elements defining a first tissue engaging region and a second tissue engaging region spaced from the first tissue engaging region.
    Type: Grant
    Filed: October 10, 2007
    Date of Patent: July 13, 2010
    Assignees: The Trustees of the University of Pennsylvania, EndoValve, Inc.
    Inventors: David G. Lamphere, Tuan Anh Nguyen, Howard C. Herrmann
  • Publication number: 20100042208
    Abstract: A percutaneously inserted bistable heart valve prosthesis is folded inside a catheter for transseptal delivery to the patient's heart for implantation. The heart valve has an annular ring, a body member having a plurality of legs, each leg connecting at one end to the annular ring, claws that are adjustable from a first position to a second position by application of external force so as to allow ingress of surrounding heart tissue into the claws in the second position, and leaflet membranes connected to the annular ring, the body member and/or the legs, the leaflet membranes having a first position for blocking blood flow therethrough and a second position for allowing blood flow therethrough. The heart valve is designed such that upon removal of the external force the claws elastically revert to the first position so as to grip the heart tissue positioned within the claws, thereby holding the heart valve in place. The body member and claws may be integrated into a one-piece design.
    Type: Application
    Filed: October 21, 2009
    Publication date: February 18, 2010
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Howard C. Herrmann, Nilesh Mankame, Suresh G. K. Ananthasuresh
  • Patent number: 7621948
    Abstract: A percutaneously inserted bistable heart valve prosthesis is folded inside a catheter for transseptal delivery to the patient's heart for implantation. The heart valve has an annular ring, a body member having a plurality of legs, each leg connecting at one end to the annular ring, claws that are adjustable from a first position to a second position by application of external force so as to allow ingress of surrounding heart tissue into the claws in the second position, and leaflet membranes connected to the annular ring, the body member and/or the legs, the leaflet membranes having a first position for blocking blood flow therethrough and a second position for allowing blood flow therethrough. The heart valve is designed such that upon removal of the external force the claws elastically revert to the first position so as to grip the heart tissue positioned within the claws, thereby holding the heart valve in place. The body member and claws may be integrated into a one-piece design.
    Type: Grant
    Filed: July 20, 2004
    Date of Patent: November 24, 2009
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Howard C Herrmann, Nilesh Mankame, Suresh G. K. Ananthasuresh
  • Publication number: 20080221672
    Abstract: Valve prostheses are disclosed that are adapted for secure and aligned placement relative to a heart annulus. The valve prostheses may be placed in a non-invasive manner, e.g., via trans-catheter techniques. The valve prosthesis may include a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring. Each of the positioning elements defines respective proximal, intermediate, and distal tissue engaging regions cooperatively configured and dimensioned to simultaneously engage separate corresponding areas of the tissue of an anatomical structure, including respective first, second, and third elongate tissue-piercing elements.
    Type: Application
    Filed: February 8, 2008
    Publication date: September 11, 2008
    Applicants: ENDOVALVE, INC., THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: David G. Lamphere, Tuan Anh Nguyen, Howard C. Herrmann, Todd C. Tomba, Robert C. Gorman, Joseph H. Gorman
  • Publication number: 20080208328
    Abstract: Valve prosthesis systems and methods/systems for placement of such valve prostheses are provided that facilitate efficient, reliable and minimally invasive delivery modalities. The placement systems and methods permit remote manipulation and positioning of the valve prosthesis such that desirable placement relative to anatomical structures, e.g., the heart annulus, may be achieved. The valve prosthesis includes a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring. The delivery system includes a first elongate element that terminates at the valve prosthesis and is manipulable by an operator to remotely rotate the positioning elements relative to the flexible ring. A second elongate element terminates at the valve prosthesis and is manipulable by an operator to remotely advance the valve prosthesis downward into an anatomical annulus.
    Type: Application
    Filed: October 10, 2007
    Publication date: August 28, 2008
    Applicants: ENDOVALVE, INC., THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Joseph D. Antocci, David G. Lamphere, Salvatore Castro, Gregorio Ramon M. Abesames, Howard C. Herrmann
  • Publication number: 20080208332
    Abstract: Valve prostheses are disclosed that are adapted for secure and aligned placement relative to a heart annulus. The valve prostheses may be placed in a non-invasive manner, e.g., via trans-catheter techniques, and may be positioned/repositioned until proper alignment and positioning is achieved. The valve prosthesis may include a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring, each of the positioning elements defining a first tissue engaging region and a second tissue engaging region spaced from the first tissue engaging region.
    Type: Application
    Filed: October 10, 2007
    Publication date: August 28, 2008
    Applicants: ENDOVALVE, INC., THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: David G. Lamphere, Tuan Anh Nguyen, Howard C. Herrmann
  • Patent number: 5902799
    Abstract: Polyionic derivatives of cyclodextrins and methods for preparing these derivatives are provided in which a polyionic derivative of cyclodextrin is combined with a growth factor, preferably a heparin binding growth factor. These compositions are of low solubility and are applied directly to the location of a wound. By virtue of the low solubility, the compositions remain in place at the site of application and slowly release growth factor. In an alternative embodiment, the cyclodextrin derivatives are administered in the absence of growth factor and are used to absorb growth factor present in the body at the location of the wound in order to prevent overstimulation of the wound response.
    Type: Grant
    Filed: August 5, 1997
    Date of Patent: May 11, 1999
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Howard C. Herrmann, Elliot Barnathan, Paul B. Weisz
  • Patent number: 5874419
    Abstract: Polyionic derivatives of cyclodextrins and methods for preparing these derivatives are provided in which a polyionic derivative of cyclodextrin is combined with a growth factor, preferably a heparin binding growth factor. These compositions are of low solubility and are applied directly to the location of a wound. By virtue of the low solubility, the compositions remain in place at the site of application and slowly release growth factor. In an alternative embodiment, the cyclodextrin derivatives are administered in the absence of growth factor and are used to absorb growth factor present in the body at the location of the wound in order to prevent overstimulation of the wound response.
    Type: Grant
    Filed: August 4, 1997
    Date of Patent: February 23, 1999
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Howard C. Herrmann, Elliot Barnathan, Paul B. Weisz
  • Patent number: 5637575
    Abstract: Disclosed are compositions and methods effective for inhibiting restenosis. In particular, the present invention provides compositions for inhibiting undesired smooth muscle cell growth or proliferation following angioplasty in mammals, said composition comprising active agents comprising a very water-soluble derivative of cyclodextrin. The invention also provides methods of inhibiting undesired smooth muscle cell growth or proliferation following angioplasty in mammals comprising orally administering to the mammal a growth-inhibiting amount of an active agent comprising a very water-soluble derivative of cyclodextrin.
    Type: Grant
    Filed: June 23, 1993
    Date of Patent: June 10, 1997
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Howard C. Herrmann, Elliot Barnathan, Paul Weisz