Abstract: Provided herein are, inter alia, methods and compositions to detect, monitor and treat cancer, wherein the cancer includes amplified extrachromosomal oncogenes. The methods are useful for personalized treatment and exploit differential expression and chromatin structure of extrachromosomal oncogenes in cancer cells.

Abstract: Neurotoxicity associated with CD19-targeted CAR-T therapy is reduced by including an inhibitory CAR (iCAR) in the CAR-T cell, wherein the iCAR specifically recognizes an antigen specific for or associated with neurovascular mural cells (e.g. pericytes or vSMC).

Abstract: In a system and method for flexibly offering on-line promotions to visitors of a website hosted by a server, when a user signs up with the website, the server collects a plurality of user data from the visitor. If a user's data matches predetermined criteria from an advertiser, then online promotions from this advertiser are included in an opt-in window displayed to the user. In some aspects, a bifurcated client/server scripting approach isolates personally identifiable information until or unless a user opts-into an offer or offers. The server dynamically generates pricing information for each advertiser according to a flexible algorithm. The flexible algorithm depends on the type and quality of user requested by the advertiser.

Abstract: In a system and method for flexibly offering on-line promotions to visitors of a website hosted by a server, when a user signs up with the website, the server collects a plurality of user data from the visitor. If a user's data matches predetermined criteria from an advertiser, then online promotions from this advertiser are included in an opt-in window displayed to the user. In some aspects, a bifurcated client/server scripting approach isolates personally identifiable information until or unless a user opts-into an offer or offers. The server dynamically generates pricing information for each advertiser according to a flexible algorithm. The flexible algorithm depends on the type and quality of user requested by the advertiser.

Abstract: A buffer amplifier and an associated method have been provided for slew rate and swing level control in the buffering of a signal. The method accepts an input signal having a voltage swing, a swing control signal, and a slew rate control signal. The voltage swing for each output in a set of serially-connected buffer stages is selected in response to the swing control signal. The selected voltage swing for a subset of buffer stages is modified in response to the slew rate control signal. Selecting the voltage swing for each output entails selecting a source current for each buffer stage. A bias current is generated and mirrored through a current source connected to each buffer stage. Modifying the selected voltage swing for each of the subset of buffer stages includes modifying the bias current to the subset of buffer stages.

Abstract: A buffer amplifier and an associated method have been provided for slew rate and swing level control in the buffering of a signal. The method accepts an input signal having a voltage swing, a swing control signal, and a slew rate control signal. The voltage swing for each output in a set of serially-connected buffer stages is selected in response to the swing control signal. The selected voltage swing for a subset of buffer stages is modified in response to the slew rate control signal. Selecting the voltage swing for each output entails selecting a source current for each buffer stage. A bias current is generated and mirrored through a current source connected to each buffer stage. Modifying the selected voltage swing for each of the subset of buffer stages includes modifying the bias current to the subset of buffer stages.

Abstract: Methods are provided for classification of cancers by the expression of a set of genes referred to as the core serum response (CSR), or a subset thereof. The expression pattern of the CSR in normal tissues correlates with that seen in quiescent fibroblasts cultured in the absence of serum, while cancer tissues can be classified as having a quiescent or induced CSR signature. Patients with the induced CSR signature have a higher probability of metastasis. Classification according to CSR signature allows optimization of treatment, and determination of whether on whether to proceed with a specific therapy, and how to optimize dose, choice of treatment, and the like.

Abstract: The present invention relates to a chimeric pro-caspase, which contains a pro-caspase domain and an oligomerizing domain. The invention also relates to an antibody that reacts specifically with a chimeric pro-caspase. In addition, the invention further relates to a polynucleotide encoding a chimeric pro-caspase, and to nucleotide sequences, which can hybridize specifically with a polynucleotide encoding a chimeric pro-caspase. The present invention also relates to a method of inducing apoptosis in a cell by providing a chimeric pro-caspase in the cell, wherein the chimeric pro-caspase includes a pro-caspase domain and an oligomerizing domain, whereby the chimeric pro-caspase forms an oligomer in the cell, thereby activating caspase activity of the chimeric pro-caspase and inducing apoptosis in the cell.

Abstract: RNAi arrays and methods for using the same are provided. The subject arrays are characterized by having two or more distinct RNAi agents. The arrays find use in methods where cells are contacted with the arrays and the activity of the RNAi agents is determined by evaluating the contacted cells. The subject arrays and methods find use in a variety of applications, such as high throughput loss of function genomic applications.

Abstract: The present invention is to a process for producing a matrix particle of a colored lake or dye which matrix reduces the leeching or bleeding of the colored lake or dye into the surrounding medium. The present inventive process is particularly useful in toothpaste formulations.