Abstract: A treatment probe for treating an eye of a patient includes an elongate body that defines a handle and a treatment fiber that is housed within the elongate body. The treatment fiber is configured to deliver treatment light energy to the eye. A contact member is disposed on an end of the elongate body. The contact member has a contact surface for positioning on a surface of the eye, two side edges that are positioned on opposite sides of the contact surface, and a fluid channel. The contact surface conforms to the shape of the eye's sclera and the two side edges are shaped to direct fluid that is present on the surface of the eye toward the fluid channel when the contact member is moved laterally across the surface of the eye. The fluid aggregates within the fluid channel and contacts a distal end of the treatment fiber.

Abstract: Methods for labeling and imaging the accessible genome using a transposase are disclosed. In some embodiments, a bifunctional transposase complex or transposome is used to insert adaptors comprising chemical tags selectively at accessible sites in the genome where active regulatory DNA is located. Various chemical tags can be used for labeling DNA at insertion sites, including, for example, fluorescent dyes for fluorescence imaging, metal particles for electron microscopy or magnetic manipulation of DNA, isotopic labels, or biotin or other ligands, haptens, substrates, or inhibitors that are recognized by streptavidin, antibodies, enzymes, or receptors. Labeling DNA in this manner can be used to provide spatial information regarding the positioning of regulatory DNA in the genome and makes possible the imaging and sorting of cells based on the status of their regulatory DNA.

Abstract: A bioprinter and methods of using the bioprinter. The bioprinter permits selective three-dimensional movement of multiple nozzle assemblies during operation of the bioprinter. The bioprinter can be used to produce scaffold-free tissue constructs having a plurality of cellular elements interspersed among a semi-permeable vascular network. The bioprinter can also be used to print a tissue construct directly onto a tissue defect of a subject. The bioprinter can be provided as part of a bioprinting system that includes a scanner for imaging the tissue defect.

Abstract: A cybersecurity assessment system is provided for monitoring, assessing, and addressing the cybersecurity status of a target network. The cybersecurity assessment system can analyze the scan data and determine a degree to which the current status of the target network satisfies a particular cybersecurity readiness standard, and how the status changes over time. The cybersecurity assessment system can also transform large amounts of vulnerability scan data into efficient representations for use in providing interactive presentations of the vulnerabilities detected on the target network. The cybersecurity assessment system can also provide information regarding cybersecurity events in substantially real time.

Abstract: A description of a conversation may be generated to allow a person to understand important aspects of the conversation without needing to review the conversation. The conversation description may be generated by identifying one or more events that occurred in the conversation and then generating the description using the identified events. A set of possible events may be determined in advance for a particular application. The events may be identified by using an event neural network for each event. Each event neural network may process the messages of the conversation to generate an event score that indicates a match between the conversation and the corresponding event. The event scores may then be used to select one or more events. Message scores from the event neural network of a selected event may then be used to select one or more messages of the conversation as a rationale for the selected event.

Abstract: A lens or eye mask for treating an eye of a patient includes a flexible printed circuit board (PCB) that is configured to fit over at least a portion of a surface of the eye and a plurality of electrode pairs that are arranged on the flexible PCB. An electrical source is configured to provide electrical energy to each electrode pair to create a near electromagnetic field within the eye and thereby therapeutically treat target tissue within the eye. A spacing between electrodes of each electrode pair is controlled to achieve a predetermined penetration depth of the near electromagnetic field within the eye.

Abstract: An HTTP connection between a client computing device and an application is established through a reverse proxy. A response to the client computing device includes a payload instructing initiation of a non-HTTP connection (e.g., TCP, UDP). The response is modified to replace references to an original port with a dynamic port allocated to the non-HTTP connection and a temporary ACL entry is created. A subsequent connection request addressed to the dynamic port is authorized per the ACL, modified to replace the dynamic port with the original port, and forwarded to the application. Subsequent packets for the non-HTTP connection have port numbers translated between the original and dynamic ports.

Abstract: The present disclosure provides nucleic acid binding nanoprobes having one or more fluorochromes and a polymer, where each of the fluorochromes is connected to the polymer, and methods of using the same.

Abstract: A cybersecurity system is provided for automated cybersecurity insights, remediation recommendations, and service provisioning. The cybersecurity system can generate threat insights and/or generate remediation recommendations using machine learning models and cybersecurity data obtained from target networks, partners, and the like. To provision cybersecurity services, cybersecurity system may collect metadata regarding the network connections and use cases desired for one or more services. Once the metadata has been collected, the cybersecurity assessment system automatically provisions the selected services based on the provided data, such as duration of time elected, service metrics, and the like.

Abstract: A cybersecurity assessment system is provided for monitoring, assessing, and addressing the cybersecurity status of a target network. The cybersecurity assessment system may scan the target network and produce data regarding the current state and properties of devices on the target network, events occurring on the target network, vulnerabilities detected in devices on the target network, and the like. The cybersecurity assessment system can analyze the scan data and determine a degree to which the current status of the target network is in compliance with cybersecurity framework objectives. The cybersecurity assessment system can also obtain and maintain artifacts of compliance verification.

Abstract: A lens or eye mask for treating an eye of a patient includes a flexible printed circuit board (PCB) that is configured to fit over at least a portion of a surface of the eye and a plurality of electrode pairs that are arranged on the flexible PCB. An electrical source is configured to provide electrical energy to each electrode pair to create a near electromagnetic field within the eye and thereby therapeutically treat target tissue within the eye. A spacing between electrodes of each electrode pair is controlled to achieve a predetermined penetration depth of the near electromagnetic field within the eye.

Abstract: In some embodiments, an ophthalmic laser system may be provided that does not include a traditional laser console. Instead, the treatment device may be configured to house the treatment light source within the device handle. Additionally, in some embodiments, the handheld treatment device may include a user interface, such as dials and buttons, for adjusting various parameters of the therapeutic light. With certain embodiments, the self-contained handheld treatment device may be operated independent of an AC power source. For example, in some embodiments, the handheld treatment device may be battery powered. Additionally, the handheld treatment device may be disposable or may utilize replaceable distal tips in certain embodiments. Certain embodiments may be particularly designed for transscleral cyclophotocoagulation. Also, treatment guides are provided that may be configured to couple with a treatment device to align the device with a target tissue of the eye.

Abstract: A user of an automated natural language system may submit an ambiguous or incomplete request, and interactive techniques may be used to obtain clarification information from the user and then determine a response for presentation to the user. A user's initial request may be processed to compute a category score for each possible category of request. The category scores may be processed to determine if clarification of the request is needed. Where clarification is needed, one or more tags may be selected to determine a clarification question to be presented to the user. For example, a tag clarification score may be computed for each tag that indicates a value of the tag in clarifying the request. After receiving the clarification information from the user, one or more categories may be selected or, where needed, additional clarification information may be obtained.

Abstract: In some embodiments, an ophthalmic laser system may be provided that does not include a traditional laser console. Instead, the treatment device may be configured to house the treatment light source within the device handle. Additionally, in some embodiments, the handheld treatment device may include a user interface, such as dials and buttons, for adjusting various parameters of the therapeutic light. With certain embodiments, the self-contained handheld treatment device may be operated independent of an AC power source. For example, in some embodiments, the handheld treatment device may be battery powered. Additionally, the handheld treatment device may be disposable or may utilize replaceable distal tips in certain embodiments. Certain embodiments may be particularly designed for transscleral cyclophotocoagulation. Also, treatment guides are provided that may be configured to couple with a treatment device to align the device with a target tissue of the eye.

Abstract: A cybersecurity assessment system is provided for monitoring, assessing, and addressing the cybersecurity status of a hierarchy of target networks. The cybersecurity assessment system may scan individual target networks and produce data regarding the current state and properties of devices on the target networks. The cybersecurity assessment system may generate user interfaces to present cybersecurity information regarding individual target networks, and composite cybersecurity information regarding a hierarchy of target networks or some subset thereof. The cybersecurity assessment system can generate access configurations that specify which cybersecurity information of the hierarchy can be accessed by individual target networks of the hierarchy.

Abstract: An HTTP connection between a client computing device and an application is established through a reverse proxy. A response to the client computing device includes a payload instructing initiation of a non-HTTP connection (e.g., TCP, UDP). The response is modified to replace references to an original port with a dynamic port allocated to the non-HTTP connection and a temporary ACL entry is created. A subsequent connection request addressed to the dynamic port is authorized per the ACL, modified to replace the dynamic port with the original port, and forwarded to the application. Subsequent packets for the non-HTTP connection have port numbers translated between the original and dynamic ports.

Abstract: A cybersecurity assessment system is provided for monitoring, assessing, and addressing the cybersecurity status of a target network. The cybersecurity assessment system can analyze the scan data and determine a degree to which the current status of the target network satisfies a particular cybersecurity readiness standard, and how the status changes over time. The cybersecurity assessment system can also transform large amounts of vulnerability scan data into efficient representations for use in providing interactive presentations of the vulnerabilities detected on the target network. The cybersecurity assessment system can also provide information regarding cybersecurity events in substantially real time.

Abstract: A treatment probe for treating an eye of a patient includes an elongate body that defines a handle and a treatment fiber that is housed within the elongate body. The treatment fiber is configured to deliver treatment light energy to the eye. A contact member is disposed on an end of the elongate body. The contact member has a contact surface for positioning on a surface of the eye, two side edges that are positioned on opposite sides of the contact surface, and a fluid channel. The contact surface conforms to the shape of the eye's sclera and the two side edges are shaped to direct fluid that is present on the surface of the eye toward the fluid channel when the contact member is moved laterally across the surface of the eye. The fluid aggregates within the fluid channel and contacts a distal end of the treatment fiber.

Abstract: In some embodiments, a system for providing a therapeutic treatment to a patient's eye includes a treatment beam source configured to transmit a treatment beam along a treatment beam path. The system further includes a processor coupled to the treatment beam source, the processor being configured to direct the treatment beam onto retinal tissue of the patient's eye and deliver a series of short duration pulses from the treatment beam onto the retinal tissue at a first treatment spot to treat the retinal tissue. In some embodiments, a pre-treatment evaluation method using electroretinography (ERG) data may be used to predict effects of treatment beams at different power values and to determine optimal power values.

Abstract: A treatment probe for treating an eye of a patient includes an elongate body that defines a handle and a treatment fiber that is housed within the elongate body. The treatment fiber is configured to deliver treatment light energy to the eye. A contact member is disposed on an end of the elongate body. The contact member has a contact surface for positioning on a surface of the eye, two side edges that are positioned on opposite sides of the contact surface, and a fluid channel. The contact surface conforms to the shape of the eye's sclera and the two side edges are shaped to direct fluid that is present on the surface of the eye toward the fluid channel when the contact member is moved laterally across the surface of the eye. The fluid aggregates within the fluid channel and contacts a distal end of the treatment fiber.