Patents by Inventor Howard Cooke

Howard Cooke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzolactam compounds as protein kinase inhibitors
    Patent number: 11939321
    Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.
    Type: Grant
    Filed: April 7, 2021
    Date of Patent: March 26, 2024
    Assignee: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Valerio Berdini, Ildiko Maria Buck, James Edward Harvey Day, Charlotte Mary Griffiths-Jones, Thomas Daniel Heightman, Steven Howard, Christopher William Murray, David Norton, Marc O'Reilly, Alison Jo-Anne Woolford, Michael Liam Cooke, David Cousin, Stuart Thomas Onions, Jonathan Martin Shannon, John Paul Watts
  • Methods and compositions for the generation of antibodies
    Publication number: 20060156422
    Abstract: The present invention relates to a novel method for the generation of monoclonal antibodies. In particular the invention relates to a novel method for the generation of monoclonal antibodies from non-human somatic transgenic animals. Uses of antibodies generated using the method of the invention are also described.
    Type: Application
    Filed: January 10, 2005
    Publication date: July 13, 2006
    Inventors: Michael Dalrymple, Edward Gallagher, Ming Shen, Howard Cooke
  • Method for producing long DNA constructs in agarose
    Patent number: 6331397
    Abstract: The invention relates to a method for producing a DNA construct, whereby two or several DNAs are recombined in melted agarose. The invention also relates to vectors which can be used therefor, in addition to a method for providing large DNAs, especially BACs or PACs.
    Type: Grant
    Filed: May 11, 2000
    Date of Patent: December 18, 2001
    Inventors: Dirk Schindelhauer, Howard Cooke