Abstract: A system for providing professional consulting services is described, having a computer, a database including a plurality of models each containing prompts and analytics in data communication with said computer, a consultant device in data communication with said computer, the computer receiving a selection of at least one of said plurality of models from said consultant device, a user device associated with a company, the computer transmitting prompts from the selected model to said user device, responses received by said computer from said user device in reply to the selected model prompts, and a score generated by said computer comparing the responses to the analytics for the selected model.

Abstract: A computing system for initiating a suspect activity alert is described. The computing system includes at least one processor in communication with at least one memory. The at least one processor is programmed to receive transaction data associated with a plurality of processed transactions and receive rules data comprising at least one indicator of suspect activity. The at least one processor is also programmed to determine a first portion of the rules data to associate with a first portion of the transaction data and determine whether the first portion of the transaction data complies with the first portion of the rules data. The at least one processor is further configured to generate a suspect activity alert message upon determining the first portion of the transaction data does not comply with the first portion of the rules data.

Abstract: The present invention provides a method of mitigating a symptom of maladaptive substance use in a subject by inhibiting CCKB receptors. In addition, the invention provides a variety of prescreening and screening methods aimed at identifying agents that modulate a symptom of maladaptive substance use. Methods of the invention can involve assaying test agent binding to CCKB receptors. Alternatively, test agents can be screened for their ability to alter the level of CCKB receptor polypeptides, polynucleotides, or function. Finally, the invention also provides a diagnostic method that entails measuring one or more of these levels and determining risk for maladaptive substance use based on comparison to the corresponding level for a control population.

Abstract: This invention pertains to the discoveries that orexin and/or CRF increase NMDAR (N-methyl-D-aspartate receptor)-mediated currents at excitatory synapses onto a subset of dopamine cells in the ventral tegmental area (VTA) in the mammalian brain. The orexin effect can be blocked by an orexin receptor type 1 (OXR1). The CRF effect can be blocked by a CRF receptor 2 (CRF-R2) antagonist or by an inhibitor of the CRF-binding protein (CRF-BP). Methods are provided that exploit these discoveries to modulate NMDAR-mediated currents in vivo and in vitro and to screen for modulators (upregulators or downregulators) of NMDA-mediated currents. In vivo methods include the use of modulators of the orexin and CRF pathways to of mitigate a symptom of substance abuse. The invention also provides methods and compositions for co-administration of modulators that act via the orexin and CRF pathways.