Patents by Inventor Howard G. King
Howard G. King has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10768110Abstract: An apparatus and method are provided for differentiating multiple detectable signals by excitation wavelength. The apparatus can include a light source that can emit respective excitation light wavelengths or wavelength ranges towards a sample in a sample retaining region, for example, in a well. The sample can contain two or more detectable markers, for example, fluorescent dyes, each of which can be capable of generating increased detectable emissions when excited in the presence of a target component. The detectable markers can have excitation wavelength ranges and/or emission wavelength ranges that overlap with the ranges of the other detectable markers. A detector can be arranged for detecting an emission wavelength or wavelength range emitted from a first marker within the overlapping wavelength range of at least one of the other markers.Type: GrantFiled: December 18, 2009Date of Patent: September 8, 2020Assignee: Applied Biosystems, LLCInventors: Howard G. King, Steven J. Boege, Eugene F. Young, Mark F. Oldham
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Patent number: 9719925Abstract: An apparatus and method are provided for differentiating multiple detectable signals by excitation wavelength. The apparatus can include a light source that can emit respective excitation light wavelengths or wavelength ranges towards a sample in a sample retaining region, for example, in a well. The sample can contain two or more detectable markers, for example, fluorescent dyes, each of which can be capable of generating increased detectable emissions when excited in the presence of a target component. The detectable markers can have excitation wavelength ranges and/or emission wavelength ranges that overlap with the ranges of the other detectable markers. A detector can be arranged for detecting an emission wavelength or wavelength range emitted from a first marker within the overlapping wavelength range of at least one of the other markers.Type: GrantFiled: June 16, 2015Date of Patent: August 1, 2017Assignee: Applied Biosystems, LLCInventors: Howard G. King, Steven J. Boege, Eugene F. Young, Mark F. Oldham
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Publication number: 20150293024Abstract: An apparatus and method are provided for differentiating multiple detectable signals by excitation wavelength. The apparatus can include a light source that can emit respective excitation light wavelengths or wavelength ranges towards a sample in a sample retaining region, for example, in a well. The sample can contain two or more detectable markers, for example, fluorescent dyes, each of which can be capable of generating increased detectable emissions when excited in the presence of a target component. The detectable markers can have excitation wavelength ranges and/or emission wavelength ranges that overlap with the ranges of the other detectable markers. A detector can be arranged for detecting an emission wavelength or wavelength range emitted from a first marker within the overlapping wavelength range of at least one of the other markers.Type: ApplicationFiled: June 16, 2015Publication date: October 15, 2015Inventors: Howard G. King, Steven J. Boege, Eugene F. Young, Mark F. Oldham
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Patent number: 8809040Abstract: An apparatus and method are provided for differentiating multiple detectable signals by excitation wavelength. The apparatus can include a light source that can emit respective excitation light wavelengths or wavelength ranges towards a sample in a sample retaining region, for example, in a well. The sample can contain two or more detectable markers, for example, fluorescent dyes, each of which can be capable of generating increased detectable emissions when excited in the presence of a target component. The detectable markers can have excitation wavelength ranges and/or emission wavelength ranges that overlap with the ranges of the other detectable markers. A detector can be arranged for detecting an emission wavelength or wavelength range emitted from a first marker within the overlapping wavelength range of at least one of the other markers.Type: GrantFiled: December 21, 2011Date of Patent: August 19, 2014Assignee: Applied Biosystems, LLCInventors: Howard G. King, Steven J. Boege, Eugene F. Young, Mark F. Oldham
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Publication number: 20140045187Abstract: An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with excitation beams generated by a light source. The light source can include an area light array of light emitting diodes, one or more solid state lasers, one or more micro-wire lasers, or a combination thereof. According to various embodiments, a Fresnel lens can be disposed along a beam bath between the light source and the reaction regions. Methods of analysis using the optical instrument are also provided.Type: ApplicationFiled: October 15, 2013Publication date: February 13, 2014Applicant: APPLIED BIOSYSTEMS, LLCInventors: Steven J. Boege, Howard G. King, Eugene F. Young, Johannes P. Sluis, Mark F. Oldham
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Patent number: 8557569Abstract: An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with excitation beams generated by a light source. The light source can include an area light array of light emitting diodes, one or more solid state lasers, one or more micro-wire lasers, or a combination thereof. According to various embodiments, a Fresnel lens can be disposed along a beam bath between the light source and the reaction regions. Methods of analysis using the optical instrument are also provided.Type: GrantFiled: July 3, 2008Date of Patent: October 15, 2013Assignee: Applied Biosystems, LLCInventors: Steven J. Boege, Howard G. King, Eugene F. Young, Johannes P. Sluis, Mark F. Oldham
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Patent number: 8492138Abstract: An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with excitation beams generated by a light source. The light source can include an area light array of light emitting diodes, one or more solid state lasers, one or more micro-wire lasers, or a combination thereof. According to various embodiments, a Fresnel lens can be disposed along a beam bath between the light source and the reaction regions. Methods of analysis using the optical instrument are also provided.Type: GrantFiled: September 12, 2012Date of Patent: July 23, 2013Assignee: Applied Biosystems, LLCInventors: Steven J. Boege, Howard G. King, Eugene F. Young, Johannes P. Sluis, Mark F. Oldham
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Publication number: 20130011848Abstract: An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with excitation beams generated by a light source. The light source can include an area light array of light emitting diodes, one or more solid state lasers, one or more micro-wire lasers, or a combination thereof. According to various embodiments, a Fresnel lens can be disposed along a beam bath between the light source and the reaction regions. Methods of analysis using the optical instrument are also provided.Type: ApplicationFiled: September 12, 2012Publication date: January 10, 2013Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Steven J. Boege, Howard G. King, Eugene F. Young, Johannes P. Sluis, Mark F. Oldham
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Publication number: 20120087832Abstract: An apparatus and method are provided for differentiating multiple detectable signals by excitation wavelength. The apparatus can include a light source that can emit respective excitation light wavelengths or wavelength ranges towards a sample in a sample retaining region, for example, in a well. The sample can contain two or more detectable markers, for example, fluorescent dyes, each of which can be capable of generating increased detectable emissions when excited in the presence of a target component. The detectable markers can have excitation wavelength ranges and/or emission wavelength ranges that overlap with the ranges of the other detectable markers. A detector can be arranged for detecting an emission wavelength or wavelength range emitted from a first marker within the overlapping wavelength range of at least one of the other markers.Type: ApplicationFiled: December 21, 2011Publication date: April 12, 2012Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Howard G. King, Steven J. Boege, Eugene F. Young, Mark F. Oldham
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Publication number: 20100216143Abstract: An apparatus and method are provided for differentiating multiple detectable signals by excitation wavelength. The apparatus can include a light source that can emit respective excitation light wavelengths or wavelength ranges towards a sample in a sample retaining region, for example, in a well. The sample can contain two or more detectable markers, for example, fluorescent dyes, each of which can be capable of generating increased detectable emissions when excited in the presence of a target component. The detectable markers can have excitation wavelength ranges and/or emission wavelength ranges that overlap with the ranges of the other detectable markers. A detector can be arranged for detecting an emission wavelength or wavelength range emitted from a first marker within the overlapping wavelength range of at least one of the other markers.Type: ApplicationFiled: December 18, 2009Publication date: August 26, 2010Applicant: LIFE TECHNOLOGY CORPORATIONInventors: Howard G. King, Steven J. Boege, Eugene F. Young, Mark F. Oldham
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Patent number: 7635588Abstract: An apparatus and method are provided for differentiating multiple detectable signals by excitation wavelength. The apparatus can include a light source that can emit respective excitation light wavelengths or wavelength ranges towards a sample in a sample retaining region, for example, in a well. The sample can contain two or more detectable markers, for example, fluorescent dyes, each of which can be capable of generating increased detectable emissions when excited in the presence of a target component. The detectable markers can have excitation wavelength ranges and/or emission wavelength ranges that overlap with the ranges of the other detectable markers. A detector can be arranged for detecting an emission wavelength or wavelength range emitted from a first marker within the overlapping wavelength range of at least one of the other markers.Type: GrantFiled: May 19, 2003Date of Patent: December 22, 2009Assignee: Applied Biosystems, LLCInventors: Howard G. King, Steven J. Boege, Eugene F. Young, Mark F. Oldham
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Patent number: 7599060Abstract: An optical system includes a sample substrate having a surface, the surface defining a 2-dimensional sample plane. The system includes an excitation source configured to provide excitation light to the sample substrate. The system further includes an optical detector configured to receive emission light from the sample substrate and generate detection data. The system also includes a scan head configured at least (i) to direct the excitation light towards the sample substrate, (ii) to receive emission light from the sample substrate and direct the emission light towards the optical detector, and (iii) for scanning relative to the sample substrate.Type: GrantFiled: August 18, 2008Date of Patent: October 6, 2009Assignee: Applied Biosystems, LLCInventors: Jon A. Hoshizaki, Howard G. King, Johannes P. Sluis, Steven J. Boege, Mark F. Oldham
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Patent number: 7491924Abstract: An apparatus for imaging an array of a plurality of features associated with a sample tile. The apparatus includes a stage that supports the sample tile in an illumination region, and an illumination source having a plurality of LEDs adapted to emit light. At least a portion of the light illuminates the illumination region. Additionally, the apparatus includes an image collecting device adapted to selectively collect images of a signal.Type: GrantFiled: July 23, 2007Date of Patent: February 17, 2009Assignee: Applera CorporationInventors: Mark F. Oldham, Howard G. King, Douwe D. Haga, Tracy L. Ferea
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Publication number: 20090009767Abstract: An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with excitation beams generated by a light source. The light source can include an area light array of light emitting diodes, one or more solid state lasers, one or more micro-wire lasers, or a combination thereof. According to various embodiments, a Fresnel lens can be disposed along a beam bath between the light source and the reaction regions. Methods of analysis using the optical instrument are also provided.Type: ApplicationFiled: July 3, 2008Publication date: January 8, 2009Applicant: Applera CorporationInventors: Steven J. Boege, Howard G. King, Eugene F. Young, Johannes P. Sluis, Mark F. Oldham
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Publication number: 20080285879Abstract: Methods, software, and apparatus for focusing an image in biological instrument are disclosed. Focusing elements are moved to various focus positions within a focus element travel range, and sample images are captured at the various focus positions. The sample images are resolved into subregions and an optimal focus position is determined based on the image intensity statistical dispersions within the identified subregions.Type: ApplicationFiled: July 1, 2008Publication date: November 20, 2008Applicant: APPLIED BIOSYSTEMS INC.Inventors: Patrick D. Kinney, Howard G. King, Michael C. Pallas, Mark Naley
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Publication number: 20080265139Abstract: An imaging system for collecting images of signals associated with a sample tile comprising a stage supporting the sample tile, a ring illuminator system emitting a uniform excitation energy upon an entirety of the sample tile causing at least a first signal to be generated from the sample tile, and an image collecting device collecting a first image of the first signal. The image collecting device further collecting a second image of a second signal emitted from the sample tile, wherein the second signal being different than the first signal.Type: ApplicationFiled: June 30, 2008Publication date: October 30, 2008Applicant: APPLERA CORPORATIONInventors: MARK F. OLDHAM, Howard G. King, Douwe D. Haga, Tracy L. Ferea
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Patent number: 7410793Abstract: An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with excitation beams generated by a light source. The light source can include an area light array of light emitting diodes, one or more solid state lasers, one or more micro-wire lasers, or a combination thereof. According to various embodiments, a Fresnel lens can be disposed along a beam bath between the light source and the reaction regions. Methods of analysis using the optical instrument are also provided.Type: GrantFiled: May 19, 2003Date of Patent: August 12, 2008Assignee: Applera CorporationInventors: Steven J. Boege, Howard G. King, Eugene F. Young, Johannes P. Sluis, Mark F. Oldham
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Patent number: 7394943Abstract: Methods, software, and apparatus for focusing an image in biological instrument are disclosed. Focusing elements are moved to various focus positions within a focus element travel range, and sample images are captured at the various focus positions. The sample images are resolved into subregions and an optimal focus position is determined based on the image intensity statistical dispersions within the identified subregions.Type: GrantFiled: June 30, 2004Date of Patent: July 1, 2008Assignee: Applera CorporationInventors: Patrick D. Kinney, Howard G. King, Michael C. Pallas, Mark Naley
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Patent number: 7348573Abstract: Systems and methods for detecting fluorescent light by providing a filter assembly including an excitation filter and an emission filter.Type: GrantFiled: September 13, 2006Date of Patent: March 25, 2008Assignee: Applera CorporationInventor: Howard G. King
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Patent number: 7135667Abstract: An apparatus for imaging an array of a plurality of features associated with a sample tile. The apparatus can comprise a stage that supports the sample tile in an illumination region, and an illumination source having a plurality of LEDs adapted to emit light. At least a portion of the light can illuminate the illumination region. Additionally, the apparatus can comprise an image collecting device adapted to selectively collect images of either a first signal when the illumination source is illuminating the illumination region, or a second signal absent illumination of the illumination region. The first signal can have wavelengths effectively different from the wavelengths of the portion of the light emitted by the LEDs that illuminates the illumination region.Type: GrantFiled: July 22, 2005Date of Patent: November 14, 2006Assignee: Applera CorporationInventors: Mark F. Oldham, Howard G. King, Douwe D. Haga, Tracy L. Ferea