Patents by Inventor Howard G. Shertzer

Howard G. Shertzer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indenoindole compounds for use in organ preservation
    Patent number: 5719174
    Abstract: The use of antioxidants having indenoindole structure as additives to organ preservation solutions. Such a preservation solution is useful both for in site organ treatment in the donor and for organ storage after the organ is harvested. The present invention also discloses an improved organ preservation solution.
    Type: Grant
    Filed: September 30, 1994
    Date of Patent: February 17, 1998
    Assignees: Astra Aktiebolag, Univ. of Bath, Cincinnati
    Inventors: Malcolm Sainsbury, Howard G. Shertzer, Per-Ove Sjoqvist
  • Tetrahydroindenoindole compounds useful in the treatment of conditions associated with free radical formation
    Patent number: 5516788
    Abstract: The invention concerns compounds and their enantiomers of the formula IA or IB ##STR1## and pharmaceutically acceptable salts thereof wherein each of R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11 and R.sup.12 is independently selected from hydrogen or an alkyl group containing 1-6 carbon atoms and R.sup.5 is an alkoxy group containing 1-6 carbon atoms. The invention further concerns pharmaceutical compositions comprising the active compounds and methods employing the compounds for the treatment of conditions associated with free radical formation.
    Type: Grant
    Filed: January 6, 1995
    Date of Patent: May 14, 1996
    Assignees: University of Bath, University of Cincinnati, School of Medicine
    Inventors: Malcolm Sainsbury, Howard G. Shertzer
  • Dihydroindenoindole compounds and methods for using the same
    Patent number: 5185360
    Abstract: Compounds of the formula ##STR1## wherein R is hydrogen or a lower alkyl group, R.sup.1 and R.sup.2 are independently selected from hydrogen or a lower alkyl group, R.sup.3, R.sup.4 and R.sup.6 are independently selected from hydrogen, halogen or a lower alkyl group,R.sup.5 is hydrogen, hydroxy, halogen, a lower alkyl group, a lower alkoxy group, a mono- or di-lower alkylamino group, NH.sub.2 or NR.sup.11 COR.sup.12,R.sup.7, R.sup.8, R.sup.9 and R.sup.10 are independently selected from hydrogen, hydroxy, a lower alkyl group, a lower alkoxy group, a mono- or di-lower alkylamino group, NH.sub.2 or NR.sup.11 COR.sup.12,R.sup.11 is a hydrogen or a lower alkyl group,R.sup.12 is a lower alkyl group,with the proviso that when R is hydrogen then at least one of the substituents R.sup.1 to R.sup.10 is not hydrogen, or a salt thereof, are useful as antioxidants, within the medical and non-medical field, and that when R is hydrogen, methyl or neopentyl in formula IA, then at least one of R.sup.1 to R.sup.
    Type: Grant
    Filed: June 3, 1991
    Date of Patent: February 9, 1993
    Assignees: University of Bath, University of Cincinnati
    Inventors: Malcolm Sainsbury, Howard G. Shertzer