Patents by Inventor Howard Gutstein

Howard Gutstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF TREATMENT OF OPIOID TOLERANCE, PHYSICAL DEPENDENCE, PAIN, AND ADDICTION WITH INHIBITORS OF CERTAIN GROWTH FACTOR RECEPTORS
    Publication number: 20140018362
    Abstract: Methods of preventing the development and reversing or partially reversing opioid tolerance in a subject are provided herein. Such methods include the step of administering to a subject in need thereof a therapeutically effective amount of a PDGFR modulator or EGFR modulator alone or together with an opiate analgesic. The methods can also be used for the treatment of refractory neuropathic pain, physical dependence or addiction.
    Type: Application
    Filed: July 3, 2013
    Publication date: January 16, 2014
    Inventor: Howard GUTSTEIN
  • Methods of treatment of opioid tolerance, physical dependence, pain and addiction with inhibitors of certain growth factor receptors
    Patent number: 8501740
    Abstract: Methods of preventing the development and reversing or partially reversing opioid tolerance in a subject are provided herein. Such methods include the step of administering to a subject in need thereof a therapeutically effective amount of a PDGFR modulator or EGFR modulator alone or together with an opiate analgesic. The methods can also be used for the treatment of refractory neuropathic pain, physical dependence or addiction.
    Type: Grant
    Filed: October 8, 2008
    Date of Patent: August 6, 2013
    Assignee: Board of Regents, The University of Texas System
    Inventor: Howard Gutstein
  • Method and computer-program product for detecting and quantifying protein spots
    Patent number: 8031925
    Abstract: The present inventions is directed to a method and computer program product for detecting and quantifying protein spots, including: generating an average gel image by taking a pixel-by-pixel average of the intensities of a plurality of aligned gel images; detecting spots on the average gel image using pinnacle detection; and quantifying spots on individual gels using the maximum intensity within fixed neighborhoods surrounding pinnacle locations found in the average gel image.
    Type: Grant
    Filed: January 8, 2008
    Date of Patent: October 4, 2011
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Jeffrey S. Morris, Howard Gutstein
  • METHOD AND COMPUTER-PROGRAM PRODUCT FOR DETECTING AND QUANTIFYING PROTEIN SPOTS
    Publication number: 20080166030
    Abstract: The present inventions is directed to a method and computer program product for detecting and quantifying protein spots, including: generating an average gel image by taking a pixel-by-pixel average of the intensities of a plurality of aligned gel images; detecting spots on the average gel image using pinnacle detection; and quantifying spots on individual gels using the maximum intensity within fixed neighborhoods surrounding pinnacle locations found in the average gel image.
    Type: Application
    Filed: January 8, 2008
    Publication date: July 10, 2008
    Inventors: Jeffrey S. Morris, Howard Gutstein