Abstract: Copper chelates serve as cytotoxic agents in conjunction with a surface membrane protein receptor internalizing agent, particularly TNF, which has independent cytotoxic activity, for use against target cells. By employing concentrations of the two agents, where the agents have substantially reduced adverse side effects, the combination is shown to have effective cytotoxic activity.

Abstract: A method in which a variable sized segment of a memory array can be written in a single memory cycle is provided. A predetermined set of the column addresses or a combination of the column address and I/O field specify the starting location of a block of a memory array row to be written. The set of remaining column addresses specifies displacement from the starting location. Together the starting segment and the displacement define an area of memory which can be written in a single cycle.

Abstract: A dynamic random access memory having a bit line precharge capability is provided with an internally gated RAS signal, such that bit line precharge operation does not being until an internal timing signal is issued indicating completion of the read/write internal timing chains. The external RAS signal is made to transition prematurely into an inactive (or precharge) state, so that the bit line precharge operation necessarily occurs immediately after the internal timing chains are completed. This occurs independent of any circuit fabrication variations or component tolerances.